A review on hemeoxygenase-2: focus on cellular protection and oxygen response

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A review on hemeoxygenase-2: focus on cellular protection and oxygen response is …
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scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2014/604981
P932PMC publication ID4127239
P698PubMed publication ID25136403
P5875ResearchGate publication ID264903265

P50authorMaría E Chánez-CárdenasQ93365702
P2093author name stringJorge Muñoz-Sánchez
P2860cites workHeme oxygenase and heme degradationQ21710702
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HO-2 provides endogenous protection against oxidative stress and apoptosis caused by TNF-alpha in cerebral vascular endothelial cellsQ48478299
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Corticosterone promotes increased heme oxygenase-2 protein and transcript expression in the newborn rat brain.Q52201476
Heme oxygenase-1 induction protects murine cortical astrocytes from hemoglobin toxicity.Q54059269
Carbon monoxide induces vasodilation and nitric oxide release but suppresses endothelial NOS.Q54068483
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Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in miceQ44598581
Heme Oxygenase-2 Protects against Lipid Peroxidation-Mediated Cell Loss and Impaired Motor Recovery after Traumatic Brain InjuryQ44747461
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Heme inhibits human neutrophil apoptosis: involvement of phosphoinositide 3-kinase, MAPK, and NF-kappaB.Q44987487
Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in ratsQ45107973
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Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase.Q34251131
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters β-adrenergic receptor ligand-mediated cardiac dysfunctionQ34421837
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Thiol/Disulfide Redox Switches in the Regulation of Heme Binding to ProteinsQ34589250
Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosisQ34597540
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Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoformsQ35545244
Denervation of Carotid Baro‐ and Chemoreceptors in HumansQ35550958
Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative responseQ35607392
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Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioningQ35677054
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Free heme toxicity and its detoxification systems in humanQ36139710
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The heme oxygenase system: update 2005.Q36342697
CO as a cellular signaling moleculeQ36364694
Nucleotide sequence and organization of the rat heme oxygenase geneQ36426761
Heme oxygenase-2 is neuroprotective in cerebral ischemia.Q36438528
Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compoundsQ36591335
How many transcription factors does it take to turn on the heme oxygenase-1 gene?Q36600797
Multiple transcripts encoding heme oxygenase-2 in rat testis: developmental and cell-specific regulation of transcripts and proteinQ36791164
Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3.Q36878111
Hypoxia and heme oxygenases: oxygen sensing and regulation of expressionQ36948663
Revisiting heme mechanisms. A perspective on the mechanisms of nitric oxide synthase (NOS), Heme oxygenase (HO), and cytochrome P450s (CYP450s).Q37072871
Heme oxygenase is necessary for the excitatory response of cultured neonatal rat rostral ventrolateral medulla neurons to hypoxiaQ37086406
Cerebroprotective functions of HO-2.Q37090266
Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injuryQ37187635
Molecular mechanisms of BK channel activationQ37223668
Heme regulatory motifs in heme oxygenase-2 form a thiol/disulfide redox switch that responds to the cellular redox state.Q37343966
Heme oxygenase-2 deletion causes endothelial cell activation marked by oxidative stress, inflammation, and angiogenesisQ37444467
Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock proteinQ37533031
The heme oxygenase/biliverdin reductase pathway in drug research and development.Q37585361
Complement activation and disease: protective effects of hyperbilirubinaemiaQ37609484
Evidence that the heme regulatory motifs in heme oxygenase-2 serve as a thiol/disulfide redox switch regulating heme bindingQ37642980
Differential expression of heme oxygenase-1 in cultured cortical neurons and astrocytes determined by the aid of a new heme oxygenase antibody. Response to oxidative stressQ54174433
Coordinated expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 and heme oxygenase 2: evidence for a regulatory link between glycolysis and heme catabolism.Q54490894
Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis.Q54566037
Domains of rat heme oxygenase-2: the amino terminus and histidine 151 are required for heme oxidation.Q54657863
Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.Q55060466
Partial purification and reconstitution of the heme oxygenase system from pig spleen microsomes.Q55061447
Bilirubin inhibits the activation of superoxide-producing NADPH oxidase in a neutrophil cell-free systemQ67913939
The release of acetylcholine from carotid body tissues. Further study on the effects of acetylcholine and cholinergic blocking agents on the chemosensory dischargeQ68577339
Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoformQ68890134
Effects of low oxygen on the release of dopamine from the rabbit carotid body in vitroQ70627465
Unconjugated bilirubin inhibits in vitro major histocompatibility complex-unrestricted cytotoxicity of human lymphocytesQ71087476
Increased release of tumor necrosis factor-alpha and interleukin-6 in women with the syndrome of hemolysis, elevated liver enzymes, and low platelet countQ71754126
Differential effects of heme oxygenase isoforms on heme mediation of endothelial intracellular adhesion molecule 1 expressionQ73002791
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibitionQ73643152
Functional analysis of heme regulatory elements of the transcriptional activator Hap1Q73938491
Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cellsQ73959885
Heme oxygenase-2 acts to prevent neuronal death in brain cultures and following transient cerebral ischemiaQ74272605
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitorsQ79842136
Catalytically inactive heme oxygenase-2 mutant is cytoprotectiveQ80931238
Dynamic changes in expression of heme oxygenases in mouse heart and liver during hypoxiaQ81152071
Selective activation of heme oxygenase-2 by menadioneQ82269815
Hypoxemia induces expression of heme oxygenase-1 and heme oxygenase-2 proteins in the mouse myocardiumQ84698607
Mechanisms of cell protection by heme oxygenase-1.Q37670227
Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseasesQ37779566
Heme oxygenase-1/carbon monoxide: novel therapeutic strategies in critical care medicineQ37779568
The protective role of heme oxygenase-1 in cerebral ischemiaQ37792155
A central role of heme oxygenase-1 in cardiovascular protectionQ37810954
Adaptive responses to tissue injury: role of heme oxygenase-1.Q38123150
Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO?Q38320415
Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applicationsQ39648092
Structural environment dictates the biological significance of heme-responsive motifs and the role of Hsp90 in the activation of the heme activator protein Hap1Q39793408
JunB and JunD regulate human heme oxygenase-1 gene expression in renal epithelial cellsQ40186498
Hypoxia reduces the expression of heme oxygenase-2 in various types of human cell lines. A possible strategy for the maintenance of intracellular heme levelQ40264976
Nitric oxide increases carbon monoxide production by piglet cerebral microvesselsQ40645314
Hypoxia inhibits human recombinant large conductance, Ca(2+)-activated K(+) (maxi-K) channels by a mechanism which is membrane delimited and Ca(2+) sensitive.Q40734768
Normal and Heat-Induced Patterns of Expression of Heme Oxygenase-1 (HSP32) in Rat Brain: Hyperthermia Causes Rapid Induction of mRNA and ProteinQ40736064
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathwayQ40890343
The heme oxygenase system: a regulator of second messenger gasesQ41455806
Crystal structure of human heme oxygenase-1.Q41687640
Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and sizeQ41940159
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domainQ42198642
Synthesis and release of catecholamines by the cat carotid body in vitro: effects of hypoxic stimulationQ42207470
Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivityQ42289321
Characterization of the synthesis and release of catecholamine in the rat carotid body in vitroQ42484787
Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathwayQ42504746
Interaction between heme oxygenase-1 and -2 proteinsQ43622921
O(2) modulates large-conductance Ca(2+)-dependent K(+) channels of rat chemoreceptor cells by a membrane-restricted and CO-sensitive mechanism.Q43726349
Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifsQ43735655
Regulation of CO production in cerebral microvessels of newborn pigsQ44353636
Stereoselectivity of each of the three steps of the heme oxygenase reaction: hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdinQ44479675
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectoxygenQ629
inorganic compoundQ190065
enzymeQ8047
P304page(s)604981
P577publication date2014-07-17
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titleA review on hemeoxygenase-2: focus on cellular protection and oxygen response
P478volume2014

Reverse relations

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