Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis.

scientific article published on 22 May 2017

Degradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GLIA.23160
P932PMC publication ID5739592
P698PubMed publication ID28543773

P50authorAlexander GillQ43190990
Surendra S AmbegaokarQ57321068
Dennis L KolsonQ88311089
Benjamin B GelmanQ114339277
Colleen E KovacsicsQ124366641
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Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reactionQ36368672
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How many transcription factors does it take to turn on the heme oxygenase-1 gene?Q36600797
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Isolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4.Q38917939
Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generationQ38955527
Signal peptide peptidase-mediated nuclear localization of heme oxygenase-1 promotes cancer cell proliferation and invasion independent of its enzymatic activityQ38984568
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradationQ39332938
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Biochemical analysis of proteasomes from mouse microglia: induction of immunoproteasomes by interferon-gamma and lipopolysaccharideQ40903165
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Immunoproteasomes largely replace constitutive proteasomes during an antiviral and antibacterial immune response in the liverQ43819906
Gene transfection of H25A mutant heme oxygenase-1 protects cells against hydroperoxide-induced cytotoxicityQ43851374
Ubiquitin-proteasome system mediates heme oxygenase-1 degradation through endoplasmic reticulum-associated degradation pathwayQ43999017
Neopterin and interferon-gamma in serum and cerebrospinal fluid of patients with HIV-associated neurologic diseaseQ44113713
The balance mediated by miRNAs and the heme oxygenase 1 feedback loop contributes to biological effectsQ44613878
Immunoproteasome enhances intracellular proteolysis of myelin basic proteinQ44915279
Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.Q45029621
Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV.Q45111041
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Immune activation of the central nervous system is still present after >4 years of effective highly active antiretroviral therapyQ46812278
Cellular localization of tumor necrosis factor mRNA in neurological tissue from HIV-infected patients by combined reverse transcriptase/polymerase chain reaction in situ hybridization and immunohistochemistryQ48743446
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HIV-associated neurocognitive disorder - pathogenesis and prospects for treatment.Q55135038
Cognitive dysfunction in HIV patients despite long-standing suppression of viremiaQ58074796
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Identification of MECL-1 (LMP-10) as the third IFN-gamma-inducible proteasome subunitQ71483389
Interferon-gamma induces different subunit organizations and functional diversity of proteasomesQ72526211
P433issue8
P921main subjectastrocyteQ502961
heme oxygenase 1Q5631153
molecular biologyQ7202
immunoproteasomeQ106087471
neuropathogenesisQ121363649
P304page(s)1264-1277
P577publication date2017-05-22
P1433published inGliaQ15716658
P1476titleDegradation of heme oxygenase-1 by the immunoproteasome in astrocytes: A potential interferon-γ-dependent mechanism contributing to HIV neuropathogenesis
P478volume65

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cites work (P2860)
Q60939671A Dual Role of Heme Oxygenase-1 in Cancer Cells
Q64077411Antineuroinflammatory drugs in HIV-associated neurocognitive disorders as potential therapy
Q64259560DMO-CAP inhibits influenza virus replication by activating heme oxygenase-1-mediated IFN response
Q89471792Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells
Q63627708Heme oxygenase-1 deficiency promotes severity of sepsis in a non-surgical preterm mouse model
Q51743775Heme oxygenase-1 promoter region (GT)n polymorphism associates with increased neuroimmune activation and risk for encephalitis in HIV infection.
Q91871623PA28α/β Promote Breast Cancer Cell Invasion and Metastasis via Down-Regulation of CDK15

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