Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.

scientific article

Glutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1530/ERC-15-0192
P932PMC publication ID4500469
P698PubMed publication ID26045471
P5875ResearchGate publication ID277778636

P50authorVictoria Bae-JumpQ87641363
P2093author name stringChunxiao Zhou
Hui Guo
Hannah M Jones
Xiugui Sheng
Jessica E Stine
Adam K Willson
Lingqin Yuan
Dario R Roque
P2860cites workPhosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen speciesQ24305112
Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant functionQ24306243
Long-Term Clinical Outcome of Patients With Recurrent Epithelial Ovarian Carcinoma: Is it the Same for Each Histological Type?Q37990743
Ovarian cancer: risk factors, treatment and managementQ38143316
Effects of glutamine on proliferation, migration, and differentiation of human dental pulp cellsQ38970931
Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancerQ39024340
Arginine, Leucine, and Glutamine Stimulate Proliferation of Porcine Trophectoderm Cells Through the MTOR-RPS6K-RPS6-EIF4EBP1 Signal Transduction Pathway1Q39181531
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistanceQ39413719
Cell death of prostate cancer cells by specific amino acid restriction depends on alterations of glucose metabolismQ39708922
Selective amino acid restriction targets mitochondria to induce apoptosis of androgen-independent prostate cancer cellsQ40245593
Specific amino acid restriction inhibits attachment and spreading of human melanoma via modulation of the integrin/focal adhesion kinase pathway and actin cytoskeleton remodelingQ40443257
Specific amino acid dependency regulates invasiveness and viability of androgen-independent prostate cancer cellsQ40641888
Acid production in glycolysis-impaired tumors provides new insights into tumor metabolismQ40738901
Differential effects of specific amino acid restriction on glucose metabolism, reduction/oxidation status and mitochondrial damage in DU145 and PC3 prostate cancer cellsQ42485472
Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach.Q42499348
Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?Q42858457
Effects of essential amino acids or glutamine deprivation on intestinal permeability and protein synthesis in HCT-8 cells: involvement of GCN2 and mTOR pathwaysQ54630109
The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometryQ72431072
Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell linesQ74624881
Effect of glutamine analogue-acivicin on tumor induced angiogenesis in Ehrlich ascites carcinomaQ81758538
Platinum resistance after neoadjuvant chemotherapy compared to primary surgery in patients with advanced epithelial ovarian carcinomaQ85931516
Glutamine and cancer: cell biology, physiology, and clinical opportunitiesQ27011818
Cancer statistics, 2014Q27861018
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4Q28508613
Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancerQ28609305
Bidirectional transport of amino acids regulates mTOR and autophagyQ29614476
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicityQ29616651
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924Q30410498
Serum Glutamate Levels Correlate with Gleason Score and Glutamate Blockade Decreases Proliferation, Migration, and Invasion and Induces Apoptosis in Prostate Cancer CellsQ30528073
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancerQ33604129
Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancerQ34017200
Evaluation of the antitumor effects of c-Myc-Max heterodimerization inhibitor 100258-F4 in ovarian cancer cellsQ34161727
Tumor bioenergetics: an emerging avenue for cancer metabolism targeted therapyQ34179999
Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cellsQ34258961
Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitisQ34500273
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.Q34645070
Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.Q34782086
Amino acids and mTOR mediate distinct metabolic checkpoints in mammalian G1 cell cycleQ34974267
Global distribution pattern of histological subtypes of epithelial ovarian cancer: a database analysis and systematic reviewQ35099083
Mutation or loss of p53 differentially modifies TGFβ action in ovarian cancerQ35107599
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugsQ35567256
WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway.Q35840116
ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferationQ35899955
Selective amino acid restriction differentially affects the motility and directionality of DU145 and PC3 prostate cancer cellsQ36106835
Cell-cycle control in urothelial carcinoma: large-scale tissue array analysis of tumor tissue from Maine and VermontQ36345733
ATF4 regulates MYC-mediated neuroblastoma cell death upon glutamine deprivation.Q36435476
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotypeQ36484135
Bridging epigenetics and metabolism: role of non-essential amino acidsQ36891887
Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIPQ36926900
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.Q37311260
Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.Q37329509
Bithionol inhibits ovarian cancer cell growth in vitro - studies on mechanism(s) of action.Q37580909
Glutamine: pleiotropic roles in tumor growth and stress resistanceQ37837590
Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer.Q37873930
Metabolic alterations in cancer cells and therapeutic implicationsQ37908233
The Warburg effect in 2012.Q37962131
P433issue4
P921main subjectovarian cancerQ172341
P304page(s)577-591
P577publication date2015-06-04
P1433published inEndocrine-Related CancerQ3054004
P1476titleGlutamine promotes ovarian cancer cell proliferation through the mTOR/S6 pathway.
P478volume22

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cites work (P2860)
Q57135523A framework for large-scale metabolome drug profiling links coenzyme A metabolism to the toxicity of anti-cancer drug dichloroacetate
Q38792699Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling
Q132041462Deregulated Metabolic Pathways in Ovarian Cancer: Cause and Consequence
Q41779719Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer
Q37393426Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes paclitaxel in ovarian cancer
Q61797836Glutamine Addiction and Therapeutic Strategies in Lung Cancer
Q41116132Glutamine Deprivation Causes Hydrogen Peroxide-induced Interleukin-8 Expression via Jak1/Stat3 Activation in Gastric Epithelial AGS Cells
Q90705465Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis
Q37688120Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells
Q88960942Glutamine supplementation enhances development of in vitro-produced porcine embryos and increases leucine consumption from the medium
Q99711971In situ Metabolic Profiling of Ovarian Cancer Tumor Xenografts: A Digital Pathology Approach
Q36165662Low-mass-ion discriminant equation (LOME) for ovarian cancer screening
Q33626753MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer.
Q92875529Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance
Q45305650Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer.
Q89520914MicroRNA targeting energy metabolism in ovarian cancer: a potent contender for future therapeutics
Q92545450PAX2 promotes epithelial ovarian cancer progression involving fatty acid metabolic reprogramming
Q48133992Regulation of Cancer Stem Cell Metabolism by Secreted Frizzled-Related Protein 4 (sFRP4).
Q132042932Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?
Q61798997The ability to utilise ammonia as nitrogen source is cell type specific and intricately linked to GDH, AMPK and mTORC1
Q58694628The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ

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