IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development

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IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1023249P
P356DOI10.1371/JOURNAL.PONE.0123249
P932PMC publication ID4400017
P698PubMed publication ID25879751
P5875ResearchGate publication ID277618194

P50authorMartha P AlbaQ58860522
Adriana BermudezQ56778716
Magnolia VanegasQ43124910
Manuel-Elkin PatarroyoQ47866690
P2093author name stringManuel Alfonso Patarroyo
Armando Moreno-Vranich
Luis Antonio Poloche
P2860cites workGlobal malaria mortality between 1980 and 2010: a systematic analysisQ20905423
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Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionQ27675568
T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility ComplexQ27675661
Energetic basis of uncoupling folding from binding for an intrinsically disordered proteinQ27683699
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An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complexQ27733448
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Structural insights into the editing of germ-line-encoded interactions between T-cell receptor and MHC class II by Vα CDR3Q28273830
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Vaccine platforms combining circumsporozoite protein and potent immune modulators, rEA or EAT-2, paradoxically result in opposing immune responsesQ28740832
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The structure of "unstructured" regions in peptides and proteins: role of the polyproline II helix in protein folding and recognitionQ30160324
Beta-sheet preferences from first principles.Q30336519
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Statistical and conformational analysis of the electron density of protein side chainsQ33262420
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparumQ33317962
3D analysis of the TCR/pMHCII complex formation in monkeys vaccinated with the first peptide inducing sterilizing immunity against human malariaQ33545251
Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptidesQ33575103
Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasitesQ33768911
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The immunological synapse.Q34178149
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Conformation of amino acid side-chains in proteinsQ34284524
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Randomised double-blind placebo-controlled trial of SPf66 malaria vaccine in children in northwestern Thailand. Shoklo SPf66 Malaria Vaccine Trial GroupQ34397061
Redrawing the Ramachandran plot after inclusion of hydrogen-bonding constraintsQ34472047
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Epitopic overload at the site of injection may result in suppression of the immune response to combined capsular polysaccharide conjugate vaccinesQ78164000
Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineagesQ79768916
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Modelling prescribing costs in general practiceQ79899560
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A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria.Q47887725
Changing ABRA protein peptide to fit into the HLA-DRbeta1*0301 molecule renders it protection-inducingQ47991248
Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparumQ48013061
Vaccination with SPf66, a chemically synthesised vaccine, against Plasmodium falciparum malaria in ColombiaQ48013751
The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (ϕ) and psi (ψ) anglesQ48025225
Global health. Disappointing results blunt hopes for malaria vaccineQ48025781
Major histocompatibility complex and T cell interactions of a universal T cell epitope from Plasmodium falciparum circumsporozoite proteinQ48026407
Constructing a useful tool for characterizing amino acid conformers by means of quantum chemical and graph theory indicesQ50106651
A comparative study of MHC Class-II HLA-DRbeta1*0401-Col II and HLA-DRbeta1*0101-HA complexes: a theoretical point of view.Q51634740
A theoretical analysis of HLA-DRbeta1*0301-CLIP complex using the first three multipolar moments of the electrostatic field.Q51936547
Left-handed polyproline II helices commonly occur in globular proteins.Q52402236
Quantifying Aotus monkey cytokines by real-time quantitative RT-PCR.Q54708942
The IMGT/HLA databaseQ56879486
???Q24673986
The backrub motion: how protein backbone shrugs when a sidechain dancesQ34493643
Invasion of mammalian host cells by Plasmodium sporozoitesQ34522332
The study of high-affinity TCRs reveals duality in T cell recognition of antigen: specificity and degeneracy.Q34578981
A survey of left-handed polyproline II helicesQ34646317
Determinants of the polyproline II helix from modeling studiesQ34989911
Overcoming antigenic diversity by enhancing the immunogenicity of conserved epitopes on the malaria vaccine candidate apical membrane antigen-1.Q35079832
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini).Q35167465
Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2.Q35607939
A field trial to assess a blood-stage malaria vaccineQ35622737
Functionally important aromatic-aromatic and sulfur-π interactions in the D2 dopamine receptor.Q36288129
Stereoelectronic effects on polyproline conformationQ36457988
Conformation of the backbone in unfolded proteins.Q36472811
Emerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccinesQ37081574
Evolutionarily conserved amino acids that control TCR-MHC interactionQ37096091
Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine designQ37246279
Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexesQ37272711
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development.Q37857826
Functional, immunological and three-dimensional analysis of chemically synthesised sporozoite peptides as components of a fully-effective antimalarial vaccine.Q37949675
A simple model for polyproline II structure in unfolded states of alanine-based peptidesQ38270402
The cation-π interactionQ38315642
A population-based clinical trial with the SPf66 synthetic Plasmodium falciparum malaria vaccine in VenezuelaQ39311175
n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stabilityQ40685038
Randomised trial of efficacy of SPf66 vaccine against Plasmodium falciparum malaria in children in southern Tanzania.Q40694949
Migration through host cells activates Plasmodium sporozoites for infectionQ40697374
Sequence and diversity of DRB genes of Aotus nancymaae, a primate model for human malaria parasitesQ40729626
Sequence and diversity of MHC DQA and DQB genes of the owl monkey Aotus nancymaae.Q40755540
Turns revisited: a uniform and comprehensive classification of normal, open, and reverse turn families minimizing unassigned random chain portionsQ42594652
Nature of amide carbonyl--carbonyl interactions in proteinsQ42930745
Conformations of phenylalanine in the tripeptides AFA and GFG probed by combining MD simulations with NMR, FTIR, polarized Raman, and VCD spectroscopyQ43149804
Immunoglobulin kappa light-chain V, J, and C gene sequences of the owl monkey Aotus nancymaae.Q43565173
Safety, immunogenicity and protective effect of the SPf66 malaria synthetic vaccine against Plasmodium falciparum infection in a randomized double-blind placebo-controlled field trial in an endemic area of EcuadorQ43598911
Evaluation of SPf66 malaria vaccine during a 22-month follow-up field trial in the Pacific coast of Colombia.Q43905631
Induction of protective immunity against experimental infection with malaria using synthetic peptidesQ44463998
Short sequences of non-proline residues can adopt the polyproline II helical conformationQ44889268
Reduced immunogenicity of DNA vaccine plasmids in mixturesQ45872945
CD4+ T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein.Q46255231
Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunityQ46831247
Structural characterisation of sporozoite components for a multistage, multi-epitope, anti-malarial vaccine.Q47848458
Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.Q47858214
Arresting malaria parasite egress from infected red blood cells.Q47860541
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)e0123249
P577publication date2015-04-16
P1433published inPLOS OneQ564954
P1476titleIMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development
P478volume10

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cites work (P2860)
Q47303165Conserved Binding Regions Provide the Clue for Peptide-Based Vaccine Development: A Chemical Perspective.
Q36282127Identifying and characterising PPE7 (Rv0354c) high activity binding peptides and their role in inhibiting cell invasion
Q38607844Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus
Q58109386Improving the Breadth of the Host's Immune Response to Lassa Virus
Q89514056Plasmodium falciparum pre-erythrocytic stage vaccine development
Q41566130Plasmodium vivax ligand-receptor interaction: PvAMA-1 domain I contains the minimal regions for specific interaction with CD71+ reticulocytes.
Q89824050Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Model
Q38560128Recent advances in the development of a chemically synthesised anti-malarial vaccine
Q52571067Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components.
Q58611400Synthetic Evaluation of Standard and Microwave-Assisted Solid Phase Peptide Synthesis of a Long Chimeric Peptide Derived from Four Proteins
Q36151198Vaccine Strain-Specificity of Protective HLA-Restricted Class 1 P. falciparum Epitopes

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