Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components.

scientific article published on 6 April 2018

Specific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components. is …
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scholarly articleQ13442814

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P356DOI10.3389/FCHEM.2018.00106
P932PMC publication ID5898157
P698PubMed publication ID29682500

P50authorManuel-Alfonso PatarroyoQ56452541
Adriana BermudezQ56778716
Martha P AlbaQ58860522
Manuel-Elkin PatarroyoQ47866690
P2093author name stringMagnolia Vanegas
P2860cites workStructural and functional analyses of PolyProline-II helices in globular proteins.Q51497847
High accuracy prediction of beta-turns and their types using propensities and multiple alignments.Q51505896
Left-handed polyproline II helix formation is (very) locally driven.Q64911673
Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineagesQ79768916
A crystal structure of an oligoproline PPII-helix, at lastQ85906567
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3Q24303524
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acidsQ24612820
A revised set of potentials for beta-turn formation in proteinsQ24675540
X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen IIQ27746792
Crystal structure of I-Ak in complex with a dominant epitope of lysozymeQ27749020
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide unitsQ28255121
Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filteringQ29618846
How TCRs bind MHCs, peptides, and coreceptorsQ29619572
Polyproline-II helix in proteins: structure and functionQ30009896
IMPIPS: the immune protection-inducing protein structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine developmentQ30373743
Crystallographic analysis of endogenous peptides associated with HLA-DR1 suggests a common, polyproline II-like conformation for bound peptidesQ33575103
???Q24673986
A survey of left-handed polyproline II helicesQ34646317
Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini).Q35167465
Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identificationQ36260214
HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-livesQ36303660
Extension of the classical classification of β-turnsQ37257588
Human antibodies to a Mr 155,000 Plasmodium falciparum antigen efficiently inhibit merozoite invasionQ37580668
Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development.Q37857826
HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide ExchangeQ38154571
Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating OdysseusQ38607844
Functionally relevant proteins in Plasmodium falciparum host cell invasion.Q39106485
Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.Q39214326
TCR-contacting residues orientation and HLA-DRβ* binding preference determine long-lasting protective immunity against malaria.Q39642203
Turns revisited: a uniform and comprehensive classification of normal, open, and reverse turn families minimizing unassigned random chain portionsQ42594652
Aromatic-proline interactions: electronically tunable CH/π interactionsQ42971573
Structural and sequence features of two residue turns in beta-hairpinsQ43498896
Short sequences of non-proline residues can adopt the polyproline II helical conformationQ44889268
Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humansQ46324930
Phi (Φ) and psi (Ψ) angles involved in malarial peptide bonds determine sterile protective immunityQ46831247
Gauche(+) side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine.Q47858214
The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine developmentQ47984825
Critical role of HLA-DRβ* binding peptides' peripheral flanking residues in fully-protective malaria vaccine developmentQ47995511
The high immunogenicity induced by modified sporozoites' malarial peptides depends on their phi (ϕ) and psi (ψ) anglesQ48025225
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P921main subjectmalariaQ12156
malaria vaccineQ6741353
P304page(s)106
P577publication date2018-04-06
P1433published inFrontiers in ChemistryQ27725450
P1476titleSpecific β-Turns Precede PPIIL Structures Binding to Allele-Specific HLA-DRβ1* PBRs in Fully-Protective Malaria Vaccine Components.
P478volume6

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Q89824050Preliminary Evaluation of the Safety and Immunogenicity of an Antimalarial Vaccine Candidate Modified Peptide (IMPIPS) Mixture in a Murine Modelcites workP2860

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