A reduced mechanical model for cAMP-modulated gating in HCN channels

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A reduced mechanical model for cAMP-modulated gating in HCN channels is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1032204715
P356DOI10.1038/SREP40168
P932PMC publication ID5225470
P698PubMed publication ID28074902

P50authorAndrea SaponaroQ89164458
Gerhard ThielQ50674837
P2093author name stringKay Hamacher
Stephanie Weißgraeber
P2860cites workDependency map of proteins in the small ribosomal subunitQ21145691
Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolutionQ22337277
Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channelsQ24293586
Crystal structure and mechanism of a calcium-gated potassium channelQ27639064
Structural basis for modulation and agonist specificity of HCN pacemaker channelsQ27642009
Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding DomainQ27651137
High-resolution structure of the open NaK channelQ27653201
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.Q27681473
A generalized inverse for matricesQ55884838
Relating sequence evolution of HIV1-protease to its underlying molecular mechanicsQ56688820
Large Amplitude Elastic Motions in Proteins from a Single-Parameter, Atomic AnalysisQ56688821
Dynamics of heteropentameric nicotinic acetylcholine receptor: implications of the gating mechanismQ80424010
Protein structural change upon ligand binding: linear response theoryQ81560068
Structural models of the MscL gating mechanismQ28207726
Atomic structure of a Na+- and K+-conducting channelQ28296336
Cooperative transition between open and closed conformations in potassium channelsQ28473610
Dynamics of large proteins through hierarchical levels of coarse-grained structures.Q30330023
Allosteric changes in protein structure computed by a simple mechanical model: hemoglobin T<-->R2 transition.Q30336120
Efficient quantification of the importance of contacts for the dynamical stability of proteinsQ30395024
Double electron-electron resonance reveals cAMP-induced conformational change in HCN channelsQ30584262
BioPhysConnectoR: Connecting sequence information and biophysical modelsQ33562206
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteinsQ33718901
Anisotropy of fluctuation dynamics of proteins with an elastic network modelQ33931550
The S4-S5 linker couples voltage sensing and activation of pacemaker channels.Q33944447
Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound stateQ34245022
The role of shape in determining molecular motionsQ34351341
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel functionQ34407624
From funny current to HCN channels: 20 years of excitationQ34513054
Common mechanism of pore opening shared by five different potassium channelsQ34600882
Hyperpolarization-activated cation channels: from genes to functionQ34991085
Structural changes during HCN channel gating defined by high affinity metal bridges.Q36209612
Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic NucleotidesQ36363373
CNG and HCN channels: two peas, one pod.Q36387907
Intrinsic dynamics of enzymes in the unbound state and relation to allosteric regulationQ37006858
Global dynamics of proteins: bridging between structure and functionQ37700683
HCN-related channelopathies.Q37705120
Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.Q38551327
On the functional significance of soft modes predicted by coarse-grained models for membrane proteinsQ41172407
How well can we understand large-scale protein motions using normal modes of elastic network models?Q41884486
Conformational change of proteins arising from normal mode calculationsQ42646780
Computing the Amino Acid Specificity of Fluctuations in Biomolecular SystemsQ46510131
Global ribosome motions revealed with elastic network modelQ47609027
Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potentialQ47628195
Interdependence of receptor activation and ligand binding in HCN2 pacemaker channelsQ48694989
Analysis of domain motions by approximate normal mode calculationsQ48709850
Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers.Q50682308
Hinge-bending motion in citrate synthase arising from normal mode calculations.Q52322021
Molecular mechanism of cAMP modulation of HCN pacemaker channels.Q53889028
P407language of work or nameEnglishQ1860
P304page(s)40168
P577publication date2017-01-11
P1433published inScientific ReportsQ2261792
P1476titleA reduced mechanical model for cAMP-modulated gating in HCN channels
P478volume7

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cites work (P2860)
Q55449913A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Q89219274Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel
Q83226124The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
Q98177461cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4