A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

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A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. is …
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scholarly articleQ13442814

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P356DOI10.7554/ELIFE.35753
P932PMC publication ID6023613
P698PubMed publication ID29923826

P50authorLucia BanciQ21264278
Francesca CantiniQ28316949
Andrea SaponaroQ89164458
Bina SantoroQ89164465
Matteo E. MangoniQ42439630
Anna MoroniQ56436877
Vincenzo MaioneQ59682049
Pietro MesircaQ63928589
P2093author name stringAlessandro Porro
Chiara Donadoni
Annalisa Bucchi
Dario DiFrancesco
Gerhard Thiel
Bianca Introini
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Structural basis for modulation and agonist specificity of HCN pacemaker channelsQ27642009
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Protein backbone angle restraints from searching a database for chemical shift and sequence homologyQ27861108
Muscarinic modulation of cardiac rate at low acetylcholine concentrationsQ69945253
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotideQ28364054
Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulationQ28576494
Structures of the Human HCN1 Hyperpolarization-Activated ChannelQ28975760
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A reduced mechanical model for cAMP-modulated gating in HCN channelsQ30397292
Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel functionQ34407624
Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.Q34580492
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Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sitesQ35063427
Unfolded proteins and protein folding studied by NMR.Q35860163
Gating of HCN channels by cyclic nucleotides: residue contacts that underlie ligand binding, selectivity, and efficacyQ36016444
Cell-Penetrating Peptides: From Basic Research to ClinicsQ36283554
Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channelsQ36299682
Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channelsQ36445761
A secondary structural transition in the C-helix promotes gating of cyclic nucleotide-regulated ion channelsQ36812460
TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.Q37288658
Binding of the auxiliary subunit TRIP8b to HCN channels shifts the mode of action of cAMPQ37343871
HCN2 ion channels: an emerging role as the pacemakers of painQ38011927
Peptide therapeutics: current status and future directionsQ38275750
Mechanism for the inhibition of the cAMP dependence of HCN ion channels by the auxiliary subunit TRIP8b.Q38597175
The Current State of Peptide Drug Discovery: Back to the Future?Q38652744
Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8bQ39539572
Pacemaker mechanisms in cardiac tissue.Q40486018
TRIP8b regulates HCN1 channel trafficking and gating through two distinct C-terminal interaction sites.Q41894685
Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.Q47773861
Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neuronsQ48000237
Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node.Q52223109
Molecular mechanism of cAMP modulation of HCN pacemaker channels.Q53889028
Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.Q54567671
Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial nodeQ57980198
P407language of work or nameEnglishQ1860
P577publication date2018-06-20
P1433published ineLifeQ2000008
P1476titleA synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
P478volume7