A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

scientific article

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/EMI.2017.18
P932PMC publication ID5520482
P698PubMed publication ID28536429

P50authorWenjie TanQ90270090
P2093author name stringJianfang Zhou
Kun Qin
Yongliang Lou
Yingzhu Chen
Hao Jia
Yao Deng
Shuai Lu
Wenling Wang
Baoying Huang
Yueyang Yu
Jiaming Lan
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Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?Q30223960
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Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.Q30362113
A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.Q30379384
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The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodiesQ34653419
A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccinesQ35063993
Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoproteinQ35159147
Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4.Q35163604
Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infectionQ35865538
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Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus ChallengeQ36252666
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Identification and Comparison of Receptor Binding Characteristics of the Spike Protein of Two Porcine Epidemic Diarrhea Virus StrainsQ36735622
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Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity.Q39875698
Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor bindingQ40397876
Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodiesQ40437929
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Environmental Contamination and Viral Shedding in MERS Patients During MERS-CoV Outbreak in South KoreaQ40867001
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P433issue5
P921main subjectmonoclonal antibodyQ422248
Middle East respiratory syndrome coronavirusQ4902157
spike glycoproteinQ88660566
P304page(s)e37
P577publication date2017-05-24
P1433published inEmerging Microbes & InfectionsQ27724513
P1476titleA novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein
P478volume6

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cites work (P2860)
Q97519840A Universal Design of Betacoronavirus Vaccines against COVID-19, MERS, and SARS
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