Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases

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Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.4877-14.2015
P8608Fatcat IDrelease_bgdv4nfningu3kys2jf2i5gy3y
P932PMC publication ID4331638
P698PubMed publication ID25698759

P50authorJoanna S. FowlerQ7472
Nora VolkowQ457967
Helene BenvenisteQ59660227
Gene-Jack WangQ88105387
Dardo TomasiQ91450476
P2093author name stringEhsan Shokri Kojori
P2860cites workAcute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brainQ30445186
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Ethanol increases GABAergic transmission at both pre- and postsynaptic sites in rat central amygdala neuronsQ34763227
Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrationsQ35061649
Expression of monocarboxylate transporter mRNAs in mouse brain: support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brainQ36015325
The synthesis of ATP by glycolytic enzymes in the postsynaptic density and the effect of endogenously generated nitric oxideQ36724433
Increased brain uptake and oxidation of acetate in heavy drinkersQ36733426
Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposureQ37143615
Focal thalamic degeneration from ethanol and thiamine deficiency is associated with neuroimmune gene induction, microglial activation, and lack of monocarboxylic acid transportersQ37646951
New insights on the mechanism of the alcohol-induced increase in portal blood flowQ39641622
Acute alcohol effects on neuronal and attentional processing: striatal reward system and inhibitory sensory interactions under acute ethanol challengeQ39681875
Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: Validation of methodQ39703025
The ethanol withdrawal syndrome: A consequence of lack of substrate for a cerebral Krebs-cycleQ40175515
Regional cerebral metabolism in female alcoholics of moderate severity does not differ from that of controlsQ40833612
Preferential labeling of glial and meningial brain tumors with [2-(14)C]acetateQ43694533
Metabolic products of [2-(13) C]ethanol in the rat brain after chronic ethanol exposureQ44313659
Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholismQ44793759
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis.Q44962228
Acute effects of ethanol on regional brain glucose metabolism and transportQ45004127
Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brainQ45247899
Low doses of alcohol substantially decrease glucose metabolism in the human brainQ46639065
Preferential utilization of acetate by astrocytes is attributable to transport.Q47892655
Recovery of brain glucose metabolism in detoxified alcoholicsQ48177421
Neuropsychological deficits are correlated with frontal hypometabolism in positron emission tomography studies of older alcoholic patientsQ48308241
Decreased cerebral response to inhibitory neurotransmission in alcoholicsQ48326611
Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testingQ48366353
Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigmQ48398548
Decreased brain metabolism in neurologically intact healthy alcoholicsQ48446709
Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxificationQ48606090
Depression of thalamic metabolism by lorazepam is associated with sleepinessQ48822520
Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomographyQ48841187
Behavioral and subjective effects of ethanol: relationship to cerebral metabolism using PET.Q48959604
Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholicsQ49239393
Regional brain metabolism during alcohol intoxication.Q51079562
Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrateQ51664132
Analysis of fMRI Time-Series RevisitedQ57004350
Abatement by acetate of an ethanol withdrawal syndromeQ70669519
Spectroscopic imaging of the uptake kinetics of human brain ethanolQ73205295
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)3248-3255
P577publication date2015-02-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleAlcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases
P478volume35

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cites work (P2860)
Q37474797Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers.
Q39090733Altering ethanol pharmacokinetics to treat alcohol use disorder: Can you teach an old dog new tricks?
Q92340818Association Between Reduced Brain Glucose Metabolism and Cortical Thickness in Alcoholics: Evidence of Neurotoxicity
Q41725033Cannabis Abusers Show Hypofrontality and Blunted Brain Responses to a Stimulant Challenge in Females but not in Males
Q61796940Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain
Q48417506Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle
Q46836931Increased white matter metabolic rates in autism spectrum disorder and schizophrenia.
Q90667808Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions
Q47787343Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats.
Q57468207Multiple Sclerosis, Cannabis Use, and Clinical Disability: A Preliminary [F]-Fluorodeoxyglucose Positron Emission Tomography Study
Q91226853The effect of chronic neuroglycopenia on resting state networks in GLUT1 syndrome across the lifespan

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