Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor

scientific article

Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1194/JLR.M038323
P932PMC publication ID3793607
P698PubMed publication ID24002920
P5875ResearchGate publication ID256424888

P2093author name stringYuan Chen
Bingfang Yan
Ruitang Deng
Matthew Stoner
Xiulong Song
Rajani Kaimal
Leila Valanejad
P2860cites workSpontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptorQ47581425
Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy.Q52013578
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.Q52541251
Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump.Q54623947
Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injuryQ79693003
Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancyQ80063706
Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinomaQ80200717
Nuclear receptor-dependent bile acid signaling is required for normal liver regenerationQ83154070
A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasisQ22004274
Identification of a nuclear receptor for bile acidsQ22010058
Bile acids: natural ligands for an orphan nuclear receptorQ22010063
Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterolQ24540997
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expressionQ24617391
Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptorQ28114885
Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasisQ28139039
Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promotersQ28204305
Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiencyQ28254452
Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11Q28276140
LXRS and FXR: the yin and yang of cholesterol and fat metabolismQ28295718
The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type IIQ28568953
Enterohepatic bile salt transporters in normal physiology and liver diseaseQ28609705
Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinomaQ30414018
Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptorQ33967334
The hypolipidemic agent guggulsterone regulates the expression of human bile salt export pump: dominance of transactivation over farsenoid X receptor-mediated antagonismQ33968041
Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.Q34189248
Bile salt transportersQ34516267
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null miceQ35765708
The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolismQ36204119
Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expressionQ36558339
FXR signaling in metabolic diseaseQ37006382
The role of FXR in disorders of bile acid homeostasisQ37300843
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.Q38300264
Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinedionesQ39860554
Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human liversQ40398568
Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling.Q40479766
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activationQ40694910
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.Q40954998
Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.Q43521311
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pumpQ43899918
A patient with novel ABCB11 gene mutations with phenotypic transition between BRIC2 and PFIC2.Q46806291
P433issue11
P304page(s)3030-3044
P577publication date2013-09-03
P1433published inJournal of Lipid ResearchQ6295449
P1476titleMechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptor
P478volume54

Reverse relations

cites work (P2860)
Q41974559Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism
Q36261443Differential Feedback Regulation of Δ4-3-Oxosteroid 5β-Reductase Expression by Bile Acids
Q50099673Dysregulation of Δ4-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms
Q24318914Estrogen and Estrogen Receptor-α-Mediated Transrepression of Bile Salt Export Pump
Q50973887Glutamine attenuates obstructive cholestasis in rats via farnesoid X receptor-mediated regulation of Bsep and Mrp2.
Q90296417Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury
Q28831219Navigation in bile acid chemical space: discovery of novel FXR and GPBAR1 ligands
Q38289421Nuclear bile acid signaling through the farnesoid X receptor
Q38887864Role of farnesoid X receptor in cholestasis
Q34324898Transcriptional dynamics of bile salt export pump during pregnancy: mechanisms and implications in intrahepatic cholestasis of pregnancy

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