Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury

scientific article published on 08 March 2019

Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/HEP.30407
P932PMC publication ID6461497
P698PubMed publication ID30520052

P50authorXiao-Ming YinQ90296411
Shengmin YanQ59705435
Jingmei LinQ89701360
P2093author name stringYong Li
Zheng Dong
Tiangang Li
Gen-Sheng Feng
Xiaoyun Chen
Oscar W Cummings
Scott Friedman
Youngmin A Lee
Shangwei Wu
Bilon Khambu
Changshun Yu
Michael Goheen
P2860cites workRole of Nrf2 in oxidative stress and toxicityQ23919669
Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transportersQ24290568
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1Q24300456
Autophagy fights disease through cellular self-digestionQ27860902
Farnesoid X Receptor Regulates Bile Acid-Amino Acid ConjugationQ28204827
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathwayQ28238852
Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive elementQ28240487
Bile acid signaling in metabolic disease and drug therapyQ28244875
Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disordersQ28258758
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activityQ28296400
Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouseQ28510400
The role of bile salt export pump mutations in progressive familial intrahepatic cholestasis type IIQ28568953
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liverQ28571688
Mechanistic insights into isoform-dependent and species-specific regulation of bile salt export pump by farnesoid X receptorQ30409833
Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasisQ30433566
Identification of a chemical tool for the orphan nuclear receptor FXR.Q31431724
Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagyQ34086698
Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasisQ34118792
Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasisQ34164068
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonistQ34326973
Molecular basis of the Keap1-Nrf2 system.Q34482586
Transcriptional regulation of autophagy by an FXR-CREB axisQ34642248
Nutrient-sensing nuclear receptors coordinate autophagyQ34713459
Tissue-specific function of farnesoid X receptor in liver and intestineQ34714107
Cholic acid mediates negative feedback regulation of bile acid synthesis in miceQ34785939
Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesisQ35195305
Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestineQ35993987
Relevance of FXR-p62/SQSTM1 pathway for survival and protection of mouse hepatocytes and liver, especially with steatosisQ36249266
Regulation of Liver Metabolism by AutophagyQ36505751
Functions of autophagy in normal and diseased liverQ37107125
FXR: a metabolic regulator and cell protectorQ37282312
Emerging regulation and functions of autophagyQ38118567
Historical landmarks of autophagy researchQ38173674
Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptorQ38313790
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasisQ40271507
Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine.Q40954998
Increase in bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2.Q43893623
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.Q52541251
HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.Q52646732
Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.Q54377170
Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systemsQ84518174
P433issue5
P921main subjectautophagyQ288322
P304page(s)2196-2213
P577publication date2019-03-08
P1433published inHepatologyQ15724398
P1476titleHepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury
P478volume69

Reverse relations

cites work (P2860)
Q90720198Autophagy, Metabolism, and Alcohol-Related Liver Disease: Novel Modulators and Functions
Q89464205Dysregulated FXR-FGF19 signaling and choline metabolism are associated with gut dysbiosis and hyperplasia in a novel pig model of pediatric NASH
Q90318259Hepatic senescence, the good and the bad
Q94550192The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors

Search more.