Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis

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Liver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/HEP.23801
P932PMC publication ID2947599
P698PubMed publication ID20722001

P2093author name stringDonna B Stolz
Jaideep Behari
Satdarshan P S Monga
Vijay Singh
Jonathan Franks
Baobo Zou
Eizaburo Sasatomi
Lindsay Krauland
Tzu-Hsuan Yeh
Prathab Devaraj
P2860cites workSfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signalingQ24311745
Wnt/beta-catenin signaling: components, mechanisms, and diseasesQ24630938
Liver-specific beta-catenin knockout mice exhibit defective bile acid and cholesterol homeostasis and increased susceptibility to diet-induced steatohepatitisQ24645373
Changes in WNT/beta-catenin pathway during regulated growth in rat liver regenerationQ28364561
Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gutQ28581268
Liver-targeted disruption of Apc in mice activates beta-catenin signaling and leads to hepatocellular carcinomasQ28592004
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesisQ29617241
Dilated bile canaliculi and attenuated decrease of nerve-dependent bile secretion in connexin32-deficient mouse liverQ31027212
Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasisQ33644429
Bile salt transporters: molecular characterization, function, and regulationQ34186800
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte culturesQ34315222
Senescence marker protein-30 (SMP30) induces formation of microvilli and bile canaliculi in Hep G2 cells.Q34394913
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stressQ34801719
Regulation of the blood?biliary barrier: interaction between gap and tight junctions in hepatocytesQ35541191
Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development.Q35666104
New perspectives for the treatment of cholestasis: lessons from basic science applied clinicallyQ35741546
Adherens and tight junctions: structure, function and connections to the actin cytoskeletonQ36940193
New molecular insights into the mechanisms of cholestasis.Q37549040
Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cellsQ39904783
Cell polarity development and protein trafficking in hepatocytes lacking E-cadherin/beta-catenin-based adherens junctionsQ40146581
Conditional deletion of beta-catenin reveals its role in liver growth and regenerationQ42504022
Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic miceQ44567711
beta-Catenin and met deregulation in childhood HepatoblastomasQ46741023
Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.Q53326694
Intrahepatic cholestasis as a canalicular motility disorder. Evidence using cytochalasinQ71227878
Sinusoidal ultrastructure evaluated during the revascularization of regenerating rat liverQ73427451
Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutationsQ80289157
Repression of Wnt/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas developmentQ80346251
Nuclear receptor-dependent bile acid signaling is required for normal liver regenerationQ83154070
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
P304page(s)1410-1419
P577publication date2010-10-01
P1433published inHepatologyQ15724398
P1476titleLiver-specific β-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis
P478volume52

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cites work (P2860)
Q91940731Activation of WNT/Beta-Catenin Signaling and Regulation of the Farnesoid X Receptor/Beta-Catenin Complex After Murine Bile Duct Ligation
Q64102673Blood-Bile Barrier: Morphology, Regulation, and Pathophysiology
Q41918169Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis
Q48238819Extracellular matrix scaffolding guides lumen elongation by inducing anisotropic intercellular mechanical tension
Q90296417Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury
Q37699357Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease
Q52726477Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.
Q39297334Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions
Q41643115Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2(-/-) mice
Q47429442Interrelationship of canonical and non-canonical Wnt signalling pathways in chronic metabolic diseases
Q57057500Loss of hepatocyte β-Catenin protects mice from experimental porphyria-associated liver injury
Q34424374Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.
Q90184673Metabolic and non-metabolic liver zonation is established non-synchronously and requires sinusoidal Wnts
Q47741653Novel β-catenin/farnesoid X receptor interaction regulates hepatic bile acid metabolism during cholestasis
Q37986563Ontogenesis of hepatic and pancreatic stem cells
Q92787316Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation
Q55662464Peribiliary Glands as the Cellular Origin of Biliary Tract Cancer.
Q57284658Prevention of Cell Growth by Suppression of Villin Expression in Lithocholic Acid-stimulated HepG2 Cells
Q39454371Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b.
Q38601609Spontaneous repopulation of β-catenin null livers with β-catenin-positive hepatocytes after chronic murine liver injury
Q57152117T-cell factor 4 and β-catenin chromatin occupancies pattern zonal liver metabolism in mice
Q35819799The Wnt/β-catenin signaling pathway in liver biology and disease
Q39040911The ascending pathophysiology of cholestatic liver disease.
Q41780489Transient receptor potential canonical 5 channels plays an essential role in hepatic dyslipidemia associated with cholestasis.
Q40383119Vps33b is crucial for structural and functional hepatocyte polarity
Q92422653WNT Signaling in Disease
Q93209106Wnt-β-catenin signalling in liver development, health and disease
Q93139128Wnt/β-Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease
Q50070375Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
Q50887090β-Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis.
Q42069262β-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice

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