scholarly article | Q13442814 |
P50 | author | Rafael Rosell | Q30003989 |
Ramaswamy Govindan | Q59526758 | ||
Giorgio Scagliotti | Q87768560 | ||
Silvia Novello | Q104693149 | ||
P2093 | author name string | Julie R Brahmer | |
Paulina Selaru | |||
Heidi H Gillenwater | |||
Mark A Socinski | |||
Chandra P Belani | |||
James N Atkins | |||
Jose M Sanchez | |||
Cinta Pallares | |||
Lesley Tye | |||
Richard C Chao | |||
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Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy | Q34547495 | ||
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SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo | Q44280921 | ||
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P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | lung cancer | Q47912 |
multicenter clinical trial | Q6934595 | ||
phase II clinical trial | Q42824440 | ||
P304 | page(s) | 650-656 | |
P577 | publication date | 2008-02-01 | |
P1433 | published in | Journal of Clinical Oncology | Q400292 |
P1476 | title | Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer | |
P478 | volume | 26 |
Q33407426 | A Phase I Trial of Sunitinib and Rapamycin in Patients with Advanced Non-Small Cell Lung Cancer |
Q33397590 | A phase I dose-escalation and pharmacokinetic study of sunitinib in combination with pemetrexed in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer |
Q34250125 | A phase I, dose-finding study of sunitinib in combination with irinotecan in patients with advanced solid tumours |
Q54621891 | A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer. |
Q33398787 | A phase II study of sunitinib as a second-line treatment in advanced biliary tract carcinoma: A multicentre, multinational study |
Q43279004 | A phase II study of sunitinib in patients with locally advanced or metastatic cervical carcinoma: NCIC CTG Trial IND.184. |
Q54656439 | A phase II study of sunitinib in patients with recurrent epithelial ovarian and primary peritoneal carcinoma: an NCIC Clinical Trials Group Study. |
Q35135727 | A phase Ib study of combined VEGFR and mTOR inhibition with vatalanib and everolimus in patients with advanced renal cell carcinoma |
Q33408559 | A randomized, double-blind, phase II study of erlotinib with or without sunitinib for the second-line treatment of metastatic non-small-cell lung cancer (NSCLC). |
Q41876315 | Acquired tumor cell resistance to sunitinib by increased invasion and epithelial-mesenchymal transition in LL/2 murine lung cancer |
Q40322647 | Acute renal failure after treatment with sunitinib in a patient with multiple myeloma |
Q36161541 | Adding to the Mix: Fibroblast Growth Factor and Platelet-Derived Growth Factor Receptor Pathways as Targets in Non – small Cell Lung Cancer |
Q33708516 | Amplification of chromosomal segment 4q12 in non-small cell lung cancer |
Q38077494 | An update on molecularly targeted therapies in second- and third-line treatment in non-small cell lung cancer: focus on EGFR inhibitors and anti-angiogenic agents |
Q37977440 | Ancillary testing in lung cancer diagnosis |
Q37435385 | Angiogenesis in the treatment of non-small cell lung cancer |
Q37138254 | Angiogenesis inhibitors in the treatment of non-small-cell lung cancer (NSCLC). |
Q54524450 | Anti-angiogenic agents in the treatment of lung cancer: indications and toxicities |
Q34821321 | Anti-angiogenic agents in the treatment of non-small cell lung cancer |
Q37688711 | Anti-vascular endothelial growth factor therapies and cardiovascular toxicity: what are the important clinical markers to target? |
Q36563542 | Antiangiogenic Therapy for Cancer: An Update |
Q38153445 | Antiangiogenic agents and chemotherapy in advanced non-small cell lung cancer: a clinical perspective |
Q37981514 | Antiangiogenic agents as second-line therapy for advanced non-small cell lung cancer |
Q34854658 | Antiangiogenic agents in combination with chemotherapy in patients with advanced non-small cell lung cancer. |
Q38000486 | Antiangiogenic agents in the management of non-small cell lung cancer: where do we stand now and where are we headed? |
Q36354404 | Aptamer-nanoparticle assembly for logic-based detection |
Q38085684 | Axitinib for the treatment of advanced non-small-cell lung cancer |
Q38116094 | BIBF 1120/ nintedanib : a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer |
Q38627885 | Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib |
Q37796083 | Benefits and limitations of antiangiogenic agents in patients with non-small cell lung cancer |
Q37773367 | Benefits from pharmacological and pharmacokinetic properties of sunitinib for clinical development. |
Q37980593 | Beyond Bevacizumab: Antiangiogenic Agents |
Q43077944 | Bleeding complications of antiangiogenic therapy: pathogenetic mechanisms and clinical impact |
Q37921797 | Blocking the interaction of vascular endothelial growth factor receptors with their ligands and their effector signaling as a novel therapeutic target for cancer: time for a new look? |
Q53265222 | Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration |
Q43179458 | Bronchial fistula associated with sunitinib in a patient previously treated with radiation therapy |
Q34836398 | CALGB 30704 (Alliance): A randomized phase II study to assess the efficacy of pemetrexed or sunitinib or pemetrexed plus sunitinib in the second-line treatment of advanced non-small-cell lung cancer |
Q35346619 | Cardiovascular toxicities: clues to optimal administration of vascular endothelial growth factor signaling pathway inhibitors |
Q37895767 | Challenges in the current antiangiogenic treatment paradigm for patients with non-small cell lung cancer |
Q33988445 | Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized phase III trial |
Q37614566 | Chemotherapy for lung cancer: the state of the art in 2009. |
Q38956300 | Clinical potential of nintedanib for the second-line treatment of advanced non-small-cell lung cancer: current evidence |
Q47305390 | Clinical response to apatinib monotherapy in advanced non-small cell lung cancer. |
Q37613493 | Combining radiation, immunotherapy, and antiangiogenesis agents in the management of cancer: the Three Musketeers or just another quixotic combination? |
Q38091669 | Comparison of the efficacy and safety of single-agent erlotinib and doublet molecular targeted agents based on erlotinib in advanced non-small cell lung cancer (NSCLC): a systematic review and meta-analysis |
Q37961338 | Current and emerging medical treatments for non–small cell lung cancer: A primer for pulmonologists |
Q54548367 | Current status and future direction of multi-targeted drugs in the era of personalized therapy--overview of advances in multi-targeted therapy in non-small cell lung cancer |
Q37944183 | Developmental antiangiogenic agents for the treatment of Non-Small Cell Lung Cancer (NSCLC) |
Q38160089 | EGFR and KRAS mutations, and ALK fusions: current developments and personalized therapies for patients with advanced non-small-cell lung cancer. |
Q37945645 | Emerging antiangiogenic therapies for non-small-cell lung cancer |
Q33429478 | Emerging data with antiangiogenic therapies in early and advanced non-small-cell lung cancer |
Q37269316 | Emerging options for the management of non-small cell lung cancer |
Q36482542 | Epidermal growth factor receptor inhibitors and antiangiogenic agents for the treatment of non-small cell lung cancer |
Q37624187 | Evaluation of Safety and Efficacy of Salvage Therapy With Sunitinib, Docetaxel (Tyxan) and Cisplatinum Followed by Maintenance Vinorelbine for Unresectable/Metastatic Nonsmall Cell Lung Cancer: Stage 1 of a Simon 2 Stage Clinical Trial. [Corrected]. |
Q37788981 | Examining the safety profile of angiogenesis inhibitors: implications for clinical practice |
Q36920386 | Expression of tumor-derived vascular endothelial growth factor and its receptors is associated with outcome in early squamous cell carcinoma of the lung |
Q42861119 | Fatal necrotizing pancreatitis during combined treatment with erlotinib and sunitinib |
Q35751860 | Feasibility study of two schedules of sunitinib in combination with pemetrexed in patients with advanced solid tumors |
Q42738385 | Fibroblast growth factor signaling and inhibition in non-small cell lung cancer and their role in squamous cell tumors |
Q37512962 | Focus on Nintedanib in NSCLC and Other Tumors |
Q33777454 | Genomics of Squamous Cell Lung Cancer |
Q36822204 | HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer |
Q37286696 | HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice |
Q35572636 | Human urothelial carcinoma cell response to Sunitinib malate therapy in vitro |
Q34522899 | Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions |
Q34458274 | Identification of kinase inhibitor targets in the lung cancer microenvironment by chemical and phosphoproteomics |
Q44785223 | Impact of Different Standardized Uptake Value Measures on PET-Based Quantification of Treatment Response |
Q37512570 | Investigational agents in the management of non-small cell lung cancer. |
Q36805595 | KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib |
Q39861042 | Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors |
Q37912594 | Lung cancer associated venous thromboembolic disease: A comprehensive review |
Q34541960 | Lung cancer therapeutics that target signaling pathways: an update |
Q46049056 | Lung cancer: New biological insights and recent therapeutic advances |
Q33439007 | Maintenance Sunitinib following Initial Platinum-Based Combination Chemotherapy in Advanced-Stage IIIB/IV Non-Small Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Phase III Study-CALGB 30607 (Alliance). |
Q36709236 | Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients |
Q42986109 | Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib. |
Q37870920 | Motesanib and advanced NSCLC: experiences and expectations |
Q38245669 | Moving from histological subtyping to molecular characterization: new treatment opportunities in advanced non-small-cell lung cancer |
Q38389986 | Multi-targeted tyrosine kinase inhibitors for the treatment of non-small cell lung cancer: an era of individualized therapy |
Q54500129 | Multitargeted Tyrosine Kinase Inhibitors in Unselected Patients With Advanced Non–Small-Cell Lung Cancer (NSCLC): Impressions From MONET (the Motesanib NSCLC Efficacy and Tolerability Study) |
Q37992335 | Multitargeted anti-angiogenic agents and NSCLC: Clinical update and future directions |
Q37884982 | Multitargeted receptor tyrosine kinase inhibition: An antiangiogenic strategy in non-small cell lung cancer |
Q36766221 | Neurotoxicity of biologically targeted agents in pediatric cancer trials |
Q38014533 | New Oral Multitargeted Antiangiogenics in Non-Small-Cell Lung Cancer Treatment |
Q35660763 | New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond |
Q37357304 | New avenues for second-line treatment of metastatic non-small-cell lung cancer |
Q35667806 | New molecular targeted therapies for advanced non-small-cell lung cancer |
Q38193571 | Nintedanib for the treatment of non-small-cell lung cancer |
Q35584543 | Noncardiac Vascular Toxicities of Vascular Endothelial Growth Factor Inhibitors in Advanced Cancer: A Review |
Q37038500 | Novel Targets in Non-Small Cell Lung Cancer: ROS1 and RET Fusions |
Q28386773 | Novel insights into the molecular origins and treatment of lung cancer |
Q37984612 | Novel targets for VEGF-independent anti-angiogenic drugs. |
Q33633424 | Oral anticancer drugs: how limited dosing options and dose reductions may affect outcomes in comparative trials and efficacy in patients |
Q37855233 | Personalized Treatment of Lung Cancer |
Q37799826 | Personalized medicine for non-small-cell lung cancer. |
Q43271774 | Pharmacokinetics and safety of sunitinib malate in subjects with impaired renal function |
Q51374826 | Pharmacokinetics, Distribution, and Metabolism of [14C]Sunitinib in Rats, Monkeys, and Humans |
Q35986273 | Phase I Study of Sunitinib and Erlotinib in Advanced Nonsquamous Non-small Cell Lung Cancer |
Q33396181 | Phase I study of sunitinib and irinotecan for patients with recurrent malignant glioma |
Q33407676 | Phase I study of sunitinib plus S-1 and cisplatin in Japanese patients with advanced or metastatic gastric cancer |
Q35584072 | Phase II study of axitinib with doublet chemotherapy in patients with advanced squamous non-small-cell lung cancer |
Q37424049 | Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer |
Q42605314 | Phase II study of sunitinib as maintenance therapy in patients with locally advanced or metastatic non-small cell lung cancer |
Q33389519 | Phase II study of sunitinib as second-line treatment for advanced gastric cancer |
Q45957719 | Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors. |
Q33404543 | Phase Ib trial of the oral angiogenesis inhibitor pazopanib administered concurrently with pemetrexed in patients with advanced solid tumors |
Q43424854 | Pigmentary changes in patients treated with targeted anticancer agents: A systematic review and meta-analysis. |
Q35187806 | Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer |
Q35883400 | Plasma cytokine and angiogenic factor profiling identifies markers associated with tumor shrinkage in early-stage non-small cell lung cancer patients treated with pazopanib |
Q39816573 | Prospective analysis on survival outcomes of nonsmall cell lung cancer stages over IIIb treated with HangAm-Dan |
Q35050210 | Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC |
Q37789579 | Recent Development of Molecular-Targeted Drugs in Lung Cancer |
Q21092930 | Recent advances of novel targeted therapy in non-small cell lung cancer |
Q38130137 | Receptor tyrosine kinase alterations and therapeutic opportunities in squamous cell carcinoma of the lung |
Q49169495 | Reply: Ongoing under-reporting of clinically relevant safety data in phase II studies of tyrosine kinase inhibitors |
Q36481247 | Retrospective evaluation of the clinical and radiographic risk factors associated with severe pulmonary hemorrhage in first-line advanced, unresectable non-small-cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab |
Q35076198 | Review: Angiogenesis inhibitors in the treatment of non-small cell lung cancer |
Q37600496 | Risk of bleeding with vascular endothelial growth factor receptor tyrosine-kinase inhibitors sunitinib and sorafenib: a systematic review and meta-analysis of clinical trials |
Q37679981 | Role of epidermal growth factor receptor in lung cancer and targeted therapies |
Q37953162 | Safety Profile and Tolerability of Antiangiogenic Agents in Non–Small-Cell Lung Cancer |
Q38630725 | Safety and efficacy of targeted agents monotherapy in advanced NSCLC. |
Q37579650 | Shortcomings of current therapies for non-small-cell lung cancer: unmet medical needs |
Q37760357 | Should progression-free survival be the primary measure of efficacy for advanced NSCLC therapy? |
Q34280051 | Side effects of anti-angiogenic drugs |
Q55476332 | Stomatitis and VEGFR-Tyrosine Kinase Inhibitors (VR-TKIs): A Review of Current Literature in 4369 Patients. |
Q33409913 | Sunitinib combined with pemetrexed and carboplatin in patients with advanced solid malignancies--results of a phase I dose-escalation study |
Q44282851 | Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma |
Q33996608 | Sunitinib in combination with docetaxel in patients with advanced solid tumors: a phase I dose-escalation study |
Q33406542 | Sunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study |
Q33393174 | Sunitinib in combination with paclitaxel plus carboplatin in patients with advanced solid tumors: phase I study results |
Q34005875 | Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience |
Q44126874 | Sunitinib in pretreated advanced non-small-cell lung carcinoma: a primary result from Asian population |
Q33394774 | Sunitinib in relapsed or refractory diffuse large B-cell lymphoma: a clinical and pharmacodynamic phase II multicenter study of the NCIC Clinical Trials Group |
Q28245467 | Sunitinib in solid tumors |
Q33408323 | Sunitinib malate in previously untreated, nonsquamous, non-small cell lung cancer patients over the age of 70 years: results of a Phase II trial |
Q34567910 | Sunitinib malate synergistically potentiates anti-tumor effect of gemcitabine in human bladder cancer cells. |
Q37226817 | Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis |
Q39499521 | Synergistic interaction between sunitinib and docetaxel is sequence dependent in human non–small lung cancer with EGFR TKIs-resistant mutation |
Q37877012 | Targeted therapies for advanced non-small-cell lung cancer: Current status and future implications |
Q54411624 | Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung |
Q36054970 | Targeted therapies for lung cancer: clinical experience and novel agents |
Q35628597 | Targeted therapies for non-small cell lung cancer: an evolving landscape |
Q27022852 | Targeted therapies in development for non-small cell lung cancer |
Q37796392 | Targeted therapies of cancer: Angiogenesis inhibition seems not enough |
Q38107011 | Targeted therapy with kinase inhibitors in aggressive endocrine tumors |
Q37781113 | Targeted therapy: an evolving world of lung cancer. |
Q38964908 | Targeting Neovasculature with Multitargeted Antiangiogenesis Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer. |
Q37996080 | Targeting VEGF in lung cancer |
Q37847070 | Targeting angiogenesis from multiple pathways simultaneously: BIBF 1120, an investigational novel triple angiokinase inhibitor |
Q38154236 | Targeting angiogenesis in advanced non-small cell lung cancer |
Q26861341 | Targeting angiogenesis in squamous non-small cell lung cancer |
Q35584074 | Targeting angiogenesis with multitargeted tyrosine kinase inhibitors in the treatment of non-small cell lung cancer |
Q38060389 | Targeting tumor neovasculature in non-small-cell lung cancer |
Q39799414 | Targeting vascular endothelial growth factor receptor-1 and -3 with cediranib (AZD2171): effects on migration and invasion of gastrointestinal cancer cell lines |
Q36172732 | The Effect of Bevacizumab on Human Malignant Melanoma Cells with Functional VEGF/VEGFR2 Autocrine and Intracrine Signaling Loops |
Q37809678 | The Evolving Role of Histology in the Management of Advanced Non–Small-Cell Lung Cancer |
Q36526512 | The VEGF pathway in cancer and disease: responses, resistance, and the path forward. |
Q92081522 | The biomarkers and potential pathogenesis of lung cancer related cerebral hemorrhage |
Q36858013 | The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation |
Q38196755 | The clonal evolution and therapeutic approaches of lung cancer |
Q54403606 | The evaluation of efficacy and safety of sunitinib on EGFR-TKI pretreated advanced non-small cell lung cancer patients in China |
Q35989994 | The risk for anemia with targeted therapies for solid tumors |
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