New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond

scientific article published on 17 November 2011

New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.2147/TCRM.S22079
P932PMC publication ID3253753
P698PubMed publication ID22241943
P5875ResearchGate publication ID221744624

P2093author name stringAlberto Fulvi
Bruno Gori
Ester Del Signore
Filippo de Marinis
Serena Ricciardi
Salvatore Intagliata
P2860cites workRandomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancerQ42631933
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Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitorsQ43907793
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration.Q44106085
Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lunQ45309210
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Vandetanib versus gefitinib in patients with advanced non-small-cell lung cancer: results from a two-part, double-blind, randomized phase ii studyQ46068556
Clinical evaluation of ZD6474, an orally active inhibitor of VEGF and EGF receptor signaling, in patients with solid, malignant tumorsQ46499714
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesisQ46535751
A phase II double-blind study to investigate efficacy and safety of two doses of the triple angiokinase inhibitor BIBF 1120 in patients with relapsed advanced non-small-cell lung cancer.Q54621891
Vandetanib Versus placebo in patients with advanced non-small-cell lung cancer after prior therapy with an epidermal growth factor receptor tyrosine kinase inhibitor: a randomized, double-blind phase III trial (ZEPHYR)Q83523403
???Q28304346
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyQ27650860
Angiogenesis in cancer and other diseasesQ27861015
New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)Q28131668
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancerQ28251373
Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical resultsQ28262507
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathwaysQ28275289
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesisQ29617585
Angiogenesis as a therapeutic targetQ29619525
Angiogenic factorsQ29620582
Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancerQ30422736
Sunitinib in combination with docetaxel in patients with advanced solid tumors: a phase I dose-escalation studyQ33996608
Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancerQ34089521
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases.Q34166741
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces regression in tumor xenograftsQ34563207
Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trialQ35576189
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesisQ36111400
Inhibition of angiogenesis in the treatment of non-small cell lung cancerQ36950548
Fibroblast growth factor regulation of neovascularizationQ37129668
Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer InQ37132598
Axitinib, a novel anti-angiogenic drug with promising activity in various solid tumors.Q37179139
VEGFs and receptors involved in angiogenesis versus lymphangiogenesisQ37397202
Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancerQ37424049
Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 studyQ37633813
Axitinib (AG-013736).Q37674170
Pazopanib: Clinical development of a potent anti-angiogenic drugQ37748042
Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumorsQ40092301
Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinomaQ40275475
Synergistic antitumor effects of combined epidermal growth factor receptor and vascular endothelial growth factor receptor-2 targeted therapyQ40293653
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P304page(s)429-440
P577publication date2011-11-17
P1433published inTherapeutics and Clinical Risk ManagementQ15766913
P1476titleNew antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond
P478volume7

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cites work (P2860)
Q36996220Customised, Individualised Treatment of Metastatic Non-Small-Cell Lung Carcinoma (NSCLC)
Q38430583Nintedanib: A Review of Its Use as Second-Line Treatment in Adults with Advanced Non-Small Cell Lung Cancer of Adenocarcinoma Histology
Q39839324Pharmacokinetic Properties of Nintedanib in Healthy Volunteers and Patients With Advanced Cancer
Q36957621Reducing lung function decline in patients with idiopathic pulmonary fibrosis: potential of nintedanib

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