Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses

scientific article

Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.02320-12
P932PMC publication ID3554176
P698PubMed publication ID23192872

P50authorHans-Dieter KlenkQ1576857
Guan YiQ8962817
P2093author name stringWolfgang Garten
Eva Böttcher-Friebertshäuser
Carolin Tarnow
Folker Schwalm
Daniela Meyer
Torsten Steinmetzer
Joanna Baron
Maya Hammami
Deborah Mayoli-Nüssle
Eva Schilling
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TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.Q34120814
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Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificitiesQ36276614
An overlapping protein-coding region in influenza A virus segment 3 modulates the host responseQ36554219
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itineraryQ36753781
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activityQ36944800
Type II transmembrane serine proteases in development and diseaseQ37055730
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Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibitionQ37298015
H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chickenQ39551904
H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickensQ39594620
Novel type II transmembrane serine proteases, MSPL and TMPRSS13, Proteolytically activate membrane fusion activity of the hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replicationQ39729350
MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibitionQ39785883
Activation of influenza A viruses by trypsin treatmentQ39965584
In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinomaQ40377367
Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoproteaseQ41505675
Molecular quantitation of H9N2 avian influenza virus in various organs of broiler chickens using TaqMan real time PCR.Q42145753
Amino acid 226 in the hemagglutinin of H9N2 influenza viruses determines cell tropism and replication in human airway epithelial cellsQ42737927
Avian influenza infection in birds: a challenge and opportunity for the poultry veterinarianQ43175096
Human infection with influenza H9N2.Q43209306
Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in AsiaQ43209344
H9N2 influenza A viruses from poultry in Asia have human virus-like receptor specificityQ43209491
Natural cases and an experimental study of H9N2 avian influenza in commercial broiler chickens of Iran.Q43209713
Characterization of matriptase expression in normal human tissuesQ44519409
Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin?Q44730162
P433issue3
P304page(s)1811-1820
P577publication date2012-11-28
P1433published inJournal of VirologyQ1251128
P1476titleMatriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses
P478volume87

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