SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses

scientific article published on 07 January 2020

SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1123931655
P356DOI10.1016/J.VIROL.2020.01.004
P932PMC publication ID7112099
P698PubMed publication ID32056846

P50authorRebecca Ellis DutchQ89312730
P2093author name stringGary R Whittaker
Jonathan T Kinder
Marco R Straus
Michal Segall
P2860cites workInfluenza pandemics of the 20th centuryQ22305643
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HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase.Q35041020
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Epigenetic Silencing of SPINT2 Promotes Cancer Cell Motility via HGF-MET Pathway Activation in MelanomaQ35956303
Cleavage activation of the human-adapted influenza virus subtypes by matriptase reveals both subtype and strain specificitiesQ36276614
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The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.Q36811980
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Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activityQ36944800
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasisQ37610695
TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in miceQ37713993
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Airway proteases: an emerging drug target for influenza and other respiratory virus infections.Q39246178
Characterization of human metapneumovirus F protein-promoted membrane fusion: critical roles for proteolytic processing and low pH.Q39304996
Respiratory viruses and influenza-like illness: Epidemiology and outcomes in children aged 6 months to 10 years in a multi-country population sampleQ39352336
Epigenetic inactivation and tumor suppressor activity of HAI-2/SPINT2 in gastric cancerQ39753803
Proprotein-processing endoproteases PC6 and furin both activate hemagglutinin of virulent avian influenza viruses.Q40041650
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The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.Q41112381
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The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer CellsQ47171613
Serine peptidase inhibitor Kunitz type 2 (SPINT2) in cancer development and progression.Q52676902
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.Q55426854
Baloxavir Marboxil for Uncomplicated Influenza in Adults and AdolescentsQ59353237
Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir MarboxilQ60046097
A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activationQ84316040
HAI-2 as a novel inhibitor of plasmin represses lung cancer cell invasion and metastasisQ91597625
Human matriptase/ST 14 proteolytically cleaves H7N9 hemagglutinin and facilitates the activation of influenza A/Shanghai/2/2013 virus in cell cultureQ91837774
Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysisQ91861500
TMPRSS2 Is the Major Activating Protease of Influenza A Virus in Primary Human Airway Cells and Influenza B Virus in Human Type II PneumocytesQ92482104
Human metapneumovirus fusion protein triggering: Increasing complexities by analysis of new HMPV fusion proteinsQ92850658
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P304page(s)43-53
P577publication date2020-01-07
P1433published inVirologyQ7934867
P1476titleSPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses
P478volume543

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cites work (P2860)
Q110245709Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
Q107377038The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity

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