Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis

scientific article published on 17 January 2017

Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI88428
P932PMC publication ID5272188
P698PubMed publication ID28094766

P2093author name stringMark C Udey
Xu Feng
Michael Lu
Sohshi Morimura
Chuan-Jin Wu
P2860cites workMolecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activityQ22010006
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophyQ24292827
The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7Q24311535
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in miceQ24313255
EpCAM controls actomyosin contractility and cell adhesion by direct inhibition of PKC.Q45373544
Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in miceQ50600432
EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteinsQ50794460
Genetic analysis of Italian patients with congenital tufting enteropathyQ60679073
Biochemical analysis of a human epithelial surface antigen: differential cell expression and processingQ67976400
Nuclear signalling by tumour-associated antigen EpCAMQ24315870
Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigensQ24557431
Identification of EpCAM as the gene for congenital tufting enteropathyQ24647346
EpCAM (CD326) finding its role in cancerQ24653692
Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion moleculeQ24673345
Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymesQ28142811
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Claudin-7 regulates EpCAM-mediated functions in tumor progressionQ28566627
Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]Q29618714
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestineQ33732689
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasinQ34070450
EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic developmentQ34332606
mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/β-catenin.Q34499625
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptaseQ34568634
The role of molecular remodeling in differential regulation of tight junction permeabilityQ34617424
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrheaQ35145031
Inflammation and disruption of the mucosal architecture in claudin-7-deficient miceQ35705366
Matriptase protects against experimental colitis and promotes intestinal barrier recoveryQ35785774
Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesisQ35823094
Regulation of the intestinal epithelial barrier by the apical junctional complexQ36388836
Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathwayQ36760282
Epithelial cell adhesion molecule (EpCAM) regulates claudin dynamics and tight junctionsQ36796935
Zymogen activation, inhibition, and ectodomain shedding of matriptaseQ36991884
Regulation of epithelial cell adhesion and repulsion: role of endocytic recyclingQ37102047
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathwayQ37362059
Matriptase: a culprit in cancer?Q37401353
Functional consequences of EpCam mutation in mice and men.Q37575826
In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture.Q37672580
The matriptase-prostasin proteolytic cascade in epithelial development and pathologyQ37986624
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cellsQ38274629
The role of EpCAM in physiology and pathology of the epitheliumQ38614359
Hepatocyte growth factor activation inhibitors (HAI-1 and HAI-2) regulate HGF-induced invasion of human breast cancer cellsQ40300349
Genetic characterization of congenital tufting enteropathy: epcam associated phenotype and involvement of SPINT2 in the syndromic formQ43488017
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasisQ44007860
Primary mouse small intestinal epithelial cell culturesQ44695414
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)623-634
P577publication date2017-01-17
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMatriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
P478volume127

Reverse relations

cites work (P2860)
Q52588795Advances in Evaluation of Chronic Diarrhea in Infants.
Q58582443Blocking the proteolytic activity of zymogen matriptase with antibody-based inhibitors
Q61451740Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis
Q55515387Dysregulated HAI-2 Plays an Important Role in Renal Cell Carcinoma Bone Metastasis through Ligand-Dependent MET Phosphorylation.
Q93263869EPCAM mutation update: Variants associated with congenital tufting enteropathy and Lynch syndrome
Q57071697Emerging clinical significance of claudin-7 in colorectal cancer: a review
Q60920626Hepatocyte growth factor activator inhibitor-2 stabilizes Epcam and maintains epithelial organization in the mouse intestine
Q54948226Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy.
Q96640603Matriptase processing of APLP1 ectodomain alters its homodimerization
Q48307273Protease signaling regulates apical cell extrusion, cell contacts, and proliferation in epithelia
Q57285991Regulation of epithelial migration by epithelial cell adhesion molecule requires its Claudin-7 interaction domain
Q89709684SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses
Q47171613The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
Q37719392The Transmembrane Serine Protease HAT-like 4 Is Important for Epidermal Barrier Function to Prevent Body Fluid Loss.
Q42778244The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β amyloid

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