Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase

scientific article

Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.186874
P932PMC publication ID3037692
P698PubMed publication ID21148558

P50authorHanne B. RasmussenQ55692664
Thomas H. BuggeQ64827087
P2093author name stringChen-Yong Lin
Lotte K Vogel
Stine Friis
Jette Bornholdt
Sine Godiksen
Joanna Selzer-Plon
P2860cites workCharacterization of a novel, membrane-bound, 80-kDa matrix-degrading protease from human breast cancer cells. Monoclonal antibody production, isolation, and localizationQ95823944
Ichthyosis, follicular atrophoderma, and hypotrichosis caused by mutations in ST14 is associated with impaired profilaggrin processingQ24321438
The epidermal barrier function is dependent on the serine protease CAP1/Prss8Q24679139
Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNAQ28116250
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milkQ28137768
The emerging roles of serine protease cascades in the epidermisQ28257226
Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchorQ28505004
Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytesQ28564911
A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnoverQ28571810
Expression of prostasin and its inhibitors during colorectal cancer carcinogenesisQ33474548
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestineQ33732689
Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiationQ34181560
The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cellsQ35546542
Biogenetic pathways of plasma membrane proteins in Caco-2, a human intestinal epithelial cell lineQ36223662
Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.Q36324873
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itineraryQ36753781
Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.Q36842289
Zymogen activation, inhibition, and ectodomain shedding of matriptaseQ36991884
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrheaQ37064596
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethalityQ37197314
Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibitionQ37298015
Epithelial integrity is maintained by a matriptase-dependent proteolytic pathwayQ37362059
Apical serine protease activity is necessary for assembly of a high-resistance renal collecting duct epitheliumQ39677927
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiationQ40230886
An epithelial serine protease activates the amiloride-sensitive sodium channelQ41086195
Acute regulation of the epithelial sodium channel in airway epithelia by proteases and traffickingQ41466710
Protease inhibitors suppress the formation of tight junctions in gastrointestinal cell linesQ41626064
New therapeutic targets in ulcerative colitis: the importance of ion transporters in the human colon.Q42672596
Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasisQ44007860
The ENaC channel is required for normal epidermal differentiation.Q45989748
Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptidesQ46080677
Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1.Q46981327
Altered ENaC expression leads to impaired sodium absorption in the noninflamed intestine in Crohn's disease.Q52919538
Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.Q53333977
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)5793-5802
P577publication date2010-12-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleTransport via the transcytotic pathway makes prostasin available as a substrate for matriptase
P478volume286

Reverse relations

cites work (P2860)
Q36967340A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation
Q36115212Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells
Q47748471Alpha-1 Antitrypsin-Deficient Macrophages Have Increased Matriptase-Mediated Proteolytic Activity.
Q34722698Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes
Q37204613Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4
Q35035059Detection of active matriptase using a biotinylated chloromethyl ketone peptide
Q36520143Early detection biomarkers for ovarian cancer
Q38673072Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality.
Q52778514HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.
Q36735176Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase
Q51009956Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis
Q35979337Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation
Q41492870Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
Q33749952Matriptase zymogen supports epithelial development, homeostasis and regeneration
Q37610695Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis
Q33948580Membrane-anchored serine proteases in vertebrate cell and developmental biology
Q36217915Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner
Q36760282Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
Q39224627Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells
Q39523621Strong expression association between matriptase and its substrate prostasin in breast cancer
Q89679093The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane
Q37986624The matriptase-prostasin proteolytic cascade in epithelial development and pathology
Q34070450The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin
Q38753779The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction

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