Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders.

scientific article

Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/BS4020125
P932PMC publication ID4219245
P698PubMed publication ID25379273
P5875ResearchGate publication ID268985420

P50authorAmber M MuehlmannQ79260776
P2093author name stringElliott Richelson
Paul Fredrickson
Mona M Boules
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DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugsQ48860423
Striatal volume on magnetic resonance imaging and repetitive behaviors in autismQ48866759
Microdialysis assessment of methamphetamine-induced changes in extracellular neurotensin in the striatum and nucleus accumbens.Q48956993
Neurotensin receptors are located on dopamine-containing neurones in rat midbrainQ49134437
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Neurotensin increases endogenous glutamate release in rat cortical slicesQ62965080
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Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microgliaQ28211177
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Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trialQ28244389
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Neurotensin-deficient mice have deficits in prepulse inhibition: restoration by clozapine but not haloperidol, olanzapine, or quetiapineQ28259049
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Alterations in regional brain neurotensin concentrations produced by atypical antipsychotic drugsQ68300523
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Neurotensin-like immunoreactivity in cerebrospinal fluid of patients with schizophrenia, depression, anorexia nervosa-bulimia, and premenstrual syndromeQ69380133
Effects of short- and long-term haloperidol administration and withdrawal on regional brain cholecystokinin and neurotensin concentrations in the ratQ69597355
Effects of anticholinergic drugs on regional brain neurotensin concentrationsQ69720932
Changes in the limbic neurotensin systems induced by dopaminergic drugsQ69929296
Relation of CSF neurotensin concentrations to symptoms and drug response of psychotic patientsQ70122278
Neurotensin stimulates formation of cyclic GMP in murine neuroblastoma clone N1E-115Q70218225
Haloperidol but not clozapine increases neurotensin receptor mRNA levels in rat substantia nigraQ70472255
Isolation, structure and biologic activity of chicken intestinal neurotensinQ70807049
Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis studyQ71370125
Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in ratsQ71490894
Effects of neurotensin in a rodent model of tardive dyskinesiaQ71760128
Effects of neurotensin on the release of glutamic acid in the prefrontal cortex and striatum of the ratQ72237073
Neurotensin: perchance an endogenous neuroleptic?Q72431662
Increase of neurotensin content elicited by neuroleptics in nucleus accumbensQ72440394
Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatmentQ72533931
Effects of a novel neurotensin peptide analog given extracranially on CNS behaviors mediated by apomorphine and haloperidolQ73455068
Network interactions in schizophrenia - therapeutic implicationsQ73553195
Neurotensin inhibits neuronal Na+,K+-ATPase activity through high affinity peptide receptorQ73816029
Evidence for a role of endogenous neurotensin in the initiation of amphetamine sensitizationQ73964518
Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brainQ74326638
SchizophreniaQ79226206
Addressing side effects from antipsychotic treatment in schizophreniaQ83553940
Interactions between glutamatergic and monoaminergic systems within the basal ganglia-implications for schizophrenia and Parkinson's diseaseQ36586033
Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptidesQ36797523
Brain levels of neuropeptides in human chronic methamphetamine usersQ36852952
Comparative antipsychotic profiles of neurotensin and a related systemically active peptide agonistQ36894729
Dopamine hypothesis of schizophrenia: making sense of it all.Q36946141
Evidence for three subtypes of repetitive behavior in autism that differ in familiality and association with other symptomsQ37007579
Neurotensin in the ventral pallidum increases extracellular gamma-aminobutyric acid and differentially affects cue- and cocaine-primed reinstatementQ37168720
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitisQ37208845
Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like propertiesQ43786454
Relapse to cocaine- and heroin-seeking behavior mediated by dopamine D2 receptors is time-dependent and associated with behavioral sensitizationQ43829041
Chronic blockade of neurotensin receptors strongly reduces sensitized, but not acute, behavioral response to D-amphetamineQ43829052
The neurotensin receptor antagonist, SR48692, attenuates the expression of amphetamine-induced behavioural sensitisation in mice.Q43846382
Effects of haloperidol and risperidone on neurotensin levels in brain regions and neurotensin efflux in the ventral striatum of the rat.Q43942962
Neurotensin-induced modulation of dopamine D2 receptors and their function in rat striatum: counteraction by a NTR1-like receptor antagonist.Q43984667
Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley ratsQ44001122
d-Amphetamine-induced increase in neurotensin and neuropeptide Y outflow in the ventral striatum is mediated via stimulation of dopamine D1 and D2/3 receptorsQ44059836
NMDA-induced phosphorylation and regulation of mGluR5.Q44063851
Effect of acute and daily neurotensin and enkephalin treatments on extracellular dopamine in the nucleus accumbensQ44192962
Homer 1a gene expression modulation by antipsychotic drugs: involvement of the glutamate metabotropic system and effects of D-cycloserineQ44237544
Blockade of nicotine-induced locomotor sensitization by a novel neurotensin analog in ratsQ44260116
The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activityQ44278062
Striatal opioid peptide content in an animal model of spontaneous stereotypic behaviorQ44347720
A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonistQ44374765
Mesencephalic dopaminergic neurons in primary cultures express functional neurotensin receptorsQ44463966
Environmental enrichment: effects on stereotyped behavior and dendritic morphologyQ44470576
Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitizationQ44506396
Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout miceQ44654536
Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effectsQ44754229
Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine ReleaseQ44793030
Neurotensin agonists block the prepulse inhibition deficits produced by a 5-HT2A and an alpha1 agonistQ44859861
Neuroscience of addictionQ44880443
Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brainQ44960726
Low-affinity neurotensin receptor (NTS2) signaling: internalization-dependent activation of extracellular signal-regulated kinases 1/2.Q45054330
Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonistsQ45248983
NT69L blocks ethanol-induced increase of dopamine and glutamate levels in striatum of mouseQ45306766
A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in ratsQ45942528
The neurotensin agonist NT69L improves sensorimotor gating deficits in rats induced by a glutamatergic antagonist, but not by dopaminergic agonists.Q45999986
Intra-accumbens shell injections of SR48692 enhanced cocaine self-administration intake in rats exposed to an environmentally-elicited reinstatement paradigm.Q46011989
Refractory schizophrenia: adding aripiprazole to clozapine reduces negative but not overall symptoms.Q46036064
Impaired anorectic effect of leptin in neurotensin receptor 1-deficient miceQ46474637
Effects of 5 daily injections of the neurotensin-mimetic NT69L on the expression of neurotensin receptors in rat brainQ46476165
Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulationQ46507878
Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonistQ46510974
The effects of intra-accumbens neurotensin on sensorimotor gatingQ46654286
Metabotropic glutamate receptor 5 binding and protein expression in schizophrenia and following antipsychotic drug treatmentQ46793534
Pro-dopamine effects of neurotensin on sensorimotor gating deficitsQ46891399
A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodentsQ47239028
Neurontensin studies in alcohol naive, preferring and non-preferring ratsQ48147693
CSF concentrations of neurotensin in schizophrenia: an investigation of clinical and biochemical correlatesQ48153202
Fronto-striatal dysfunction and potential compensatory mechanisms in male adolescents with fragile X syndromeQ48201398
Effects of neurotensin gene knockout in mice on the behavioral effects of cocaine.Q48250562
Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autismQ48279049
Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptorQ48323707
Atypical neuroleptic-like behavioral effects of neurotensinQ48385983
The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate-GABA interaction via the pallidal-subthalamic nucleus loop.Q48407590
Neurotensin increases tyrosine hydroxylase messenger RNA-positive neurons in substantia nigra after retrograde axonal transportQ48452271
Craniocerebral magnetic resonance imaging measurement and findings in Lesch-Nyhan syndromeQ48482977
ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental modelsQ28303494
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTPQ28511269
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous systemQ28567151
Sustained neurotensin exposure promotes cell surface recruitment of NTS2 receptorsQ28574798
Neurotensin regulates intracellular calcium in ventral tegmental area astrocytes: evidence for the involvement of multiple receptorsQ28579384
Neurotensin depolarizes globus pallidus neurons in rats via neurotensin type-1 receptorQ28582495
Implications of normal brain development for the pathogenesis of schizophreniaQ29618740
Recent advances in the phencyclidine model of schizophreniaQ29618917
Diverse roles of neurotensin agonists in the central nervous systemQ30456105
Hyperactivity of the dopaminergic system in NTS1 and NTS2 null miceQ30475347
Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophreniaQ30475349
Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing toleranceQ30477036
NT79: A novel neurotensin analog with selective behavioral effectsQ30477584
Sensorimotor gating in neurotensin-1 receptor null miceQ30477911
Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.Q31841102
Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain.Q32065524
Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptomsQ33266464
Presynaptic action of neurotensin on dopamine release through inhibition of D(2) receptor functionQ33493599
Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorderQ33496741
D1 dopamine receptor-mediated LTP at GABA synapses encodes motivation to self-administer cocaine in ratsQ33573158
Neurotensin receptor type 1 regulates ethanol intoxication and consumption in miceQ33695438
Does neurotensin mediate the effects of antipsychotic drugs?Q33704191
Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonistsQ33749330
Neurotransmitter interactions in schizophrenia--therapeutic implicationsQ33782626
NMDA receptor hypofunction model of schizophreniaQ33813143
Glycine reuptake inhibitor RG1678: a pharmacologic characterization of an investigational agent for the treatment of schizophreniaQ34090017
Neurotensin is increased in serum of young children with autistic disorderQ34114124
Catching up on schizophrenia: natural history and neurobiologyQ34122141
Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophreniaQ34127175
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic DrugsQ34192438
Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.Q34228069
Glycine transporter inhibitor attenuates the psychotomimetic effects of ketamine in healthy males: preliminary evidenceQ34235541
The effects of neuropeptides on discrete-trial conditioned avoidance respondingQ34249385
PhencyclidineQ34280939
Endogenous neurotensin in the ventral tegmental area contributes to amphetamine behavioral sensitizationQ34382515
The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit toleranceQ37370136
Elevated immune response in the brain of autistic patientsQ37405256
The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperatureQ37442045
Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonistsQ37775612
The role of neurotensin in physiologic and pathologic processesQ37814885
Pharmacological management of acute and persistent aggression in forensic psychiatry settingsQ37963568
SHANK3 as an autism spectrum disorder-associated geneQ38023003
Update on typical and atypical antipsychotic drugsQ38047415
Metabotropic glutamate receptor 5 in the pathology and treatment of schizophrenia.Q38068703
Feeding problems and nutrient intake in children with autism spectrum disorders: a meta-analysis and comprehensive review of the literatureQ38078293
Drug discovery for autism spectrum disorder: challenges and opportunitiesQ38147860
Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensinQ39109781
Neurotensin and the mesocorticolimbic dopamine systemQ39298444
The current status of the dopamine hypothesis of schizophreniaQ39577491
The dopamine hypothesis of schizophrenia: limbic interactions with serotonin and norepinephrineQ40576758
Repetitive and self-injurious behaviors: associations with caudate volume in autism and fragile X syndromeQ40630474
Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patientsQ40808959
Mechanisms of regulation of neurotensin receptorsQ41006768
The dopamine hypothesis of schizophrenia: focus on the dopamine receptorQ41076667
Pharmacological specificity of the increase in neurotensin concentrations after antipsychotic drug treatmentQ41089455
Further studies on the modulation of regional brain neurotensin concentrations by antipsychotic drugs: focus on haloperidol and BMY 14802Q41126916
Activation of mitogen-activated protein kinase couples neurotensin receptor stimulation to induction of the primary response gene Krox-24.Q41150864
Neurotensin: central nervous system effects of a hypothalamic peptideQ41279452
Reduced CSF neurotensin concentration in drug-free schizophrenic patientsQ41393188
Role of signal transduction systems in neurotensin receptor down-regulation induced by agonist in murine neuroblastoma clone N1E-115 cells.Q41524362
The rat neurotensin receptor expressed in Chinese hamster ovary cells mediates the release of inositol phosphatesQ41597301
Structure and functional expression of the cloned rat neurotensin receptorQ41733457
Emerging roles for novel antipsychotic medications in the treatment of schizophreniaQ41743497
Autism-related behavioral abnormalities in synapsin knockout mice.Q41845734
The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortexQ41879435
The effects of systemic NT69L, a neurotensin agonist, on baseline and drug-disrupted prepulse inhibitionQ42167718
Neurotensin affects hyperactivity but not stereotypy induced by pre and post synaptic dopaminergic stimulationQ42246826
Interactions of neurotensin with brain dopamine systems: biochemical and behavioral studiesQ42254857
Targeting neurotensin as a potential novel approach for the treatment of autismQ42407155
Dopamine regulation of extracellular glutamate in the nucleus accumbensQ42442290
Differential effects of haloperidol and clozapine on neurotensin gene transcription in rat neostriatumQ42459207
The cloned neurotensin receptor mediates cyclic GMP formation when coexpressed with nitric oxide synthase cDNA.Q42476325
Neurotensin regulates cortical glutamate transmission by modulating N-methyl-D-aspartate receptor functional activity: an in vivo microdialysis studyQ42489739
Facilitation of GABA release by neurotensin is associated with a reduction of dopamine release in rat nucleus accumbensQ42492206
Rapid desensitization of agonist-induced calcium mobilization in transfected PC12 cells expressing the rat neurotensin receptorQ42504605
Development of repetitive behavior in a mouse model: roles of indirect and striosomal basal ganglia pathwaysQ42744117
The neurotensin-1 receptor agonist PD149163 inhibits conditioned avoidance responding without producing catalepsy in ratsQ42750368
Adolescent chronic apomorphine treatment impairs latent inhibition and reduces prefrontal cortex mGluR5 receptor expression in adult ratsQ42877122
Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindoleQ42961384
The difference in effect of mGlu2/3 and mGlu5 receptor agonists on cognitive impairment induced by MK-801.Q43108258
Role of neurotensin receptor 1 in the regulation of food intake by neuromedins and neuromedin-related peptides.Q43254766
Nicotine induced behavioral locomotor sensitizationQ43550716
Functional neuroanatomy of the ventral striopallidal GABA pathway. New sites of intervention in the treatment of schizophreniaQ43698345
Once weekly administration of nicotine produces long-lasting locomotor sensitization in rats via a nicotinic receptor-mediated mechanismQ43703205
A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivityQ43722020
Evidence that mesoaccumbens dopamine and locomotor responses to nicotine in the rat are influenced by pretreatment dose and strainQ43783816
Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic childrenQ34404824
CSF neurotensin concentrations and antipsychotic treatment in schizophrenia and schizoaffective disorderQ34431402
Neurotensin and dopamine interactions.Q34457618
The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugsQ34463402
Nicotine dependence in schizophrenia: clinical phenomena and laboratory findingsQ34479691
Glutamatergic mechanisms in schizophreniaQ34504043
Neurotensin selectively facilitates glutamatergic transmission in globus pallidusQ34543683
New insights into the mechanism of action of amphetaminesQ34599276
Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1).Q34645829
Antipsychotic drugs for first-episode schizophrenia: a comparative reviewQ34659096
Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2Q34680977
Dopamine D2 receptor signaling dynamics of dopamine D2-neurotensin 1 receptor heteromers.Q34691646
Effect of methamphetamine self-administration on neurotensin systems of the basal gangliaQ34702359
Mortality in a cohort of patients with schizophrenia: a record linkage studyQ34804832
Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?Q35014255
Neurotensin agonists: possible drugs for treatment of psychostimulant abuseQ35152140
Distribution of neurotensin receptors in mammalian brain. What it is telling us about its interactions with other neurotransmitter systemsQ35273394
Neurotensin, antipsychotic drugs, and schizophrenia. Basic and clinical studiesQ35273406
Intramembrane interactions between neurotensin receptors and dopamine D2 receptors as a major mechanism for the neuroleptic-like action of neurotensinQ35273456
Role of Gastrointestinal Hormones in the Proliferation of Normal and Neoplastic TissuesQ35564914
Animal behavior models of the mechanisms underlying antipsychotic atypicalityQ35595230
Neurotensin, schizophrenia, and antipsychotic drug actionQ35684732
The neurobiology of tobacco dependence: a preclinical perspective on the role of the dopamine projections to the nucleus accumbens [corrected].Q36084926
Functional interactions between presynaptic NMDA receptors and metabotropic glutamate receptors co-expressed on rat and human noradrenergic terminalsQ36094323
Differential induction of neurotensin and c-fos gene expression by typical versus atypical antipsychoticsQ36244962
Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichmentQ36251296
Theoretical insights into the mechanism of action of atypical antipsychotics.Q36386834
Behavioural pharmacology: 40+ years of progress, with a focus on glutamate receptors and cognitionQ36401781
Current schizophrenia drugs: efficacy and side effectsQ36488206
The role of neurotensin in central nervous system pathophysiology: what is the evidence?Q36544566
Functional roles of the NTS2 and NTS3 receptors.Q36548883
Bioactive analogs of neurotensin: focus on CNS effectsQ36553978
Neurotensin: role in psychiatric and neurological diseases.Q36557460
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P921main subjectpathophysiologyQ1135939
P304page(s)125-153
P577publication date2014-06-13
P1433published inBehavioral sciences (Basel, Switzerland)Q27724027
P1476titleElucidating the role of neurotensin in the pathophysiology and management of major mental disorders
P478volume4

Reverse relations

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