Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway

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Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway is …
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scholarly articleQ13442814

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P356DOI10.1523/JNEUROSCI.5803-08.2009
P932PMC publication ID3073510
P698PubMed publication ID19641113
P5875ResearchGate publication ID26703902

P50authorEdward Perez-ReyesQ56951168
Vesna Jevtovic-TodorovicQ60642341
Iuliia VitkoQ62607256
Janelle L WeaverQ88055376
P2093author name stringWoo Yong Lee
Michael T Nelson
Slobodan M Todorovic
Peihan Orestes
Ajit K Naik
Janelle Latham
P2860cites workMolecular physiology of low-voltage-activated t-type calcium channelsQ28200827
Attenuated pain responses in mice lacking Ca(V)3.2 T-type channelsQ28260743
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesiaQ28582696
Quantitative assessment of tactile allodynia in the rat pawQ29617366
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesiaQ29620385
Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channelsQ30303630
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesiaQ30433597
The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors.Q30438110
Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerveQ30439844
CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamusQ30440317
Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact ratsQ30440767
Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neuronsQ30443224
Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channelsQ30444180
Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbateQ30444989
The vanilloid receptor: a molecular gateway to the pain pathwayQ33941065
Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channelsQ34278287
Nitrosylation. the prototypic redox-based signaling mechanism.Q34381833
Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agentsQ34451739
Tackling pain at the source: new ideas about nociceptorsQ34467545
Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.Q34576734
Management of burning mouth syndrome: systematic review and management recommendationsQ34611332
Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acidQ34749673
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stressQ35768380
Lack of interaction between thioctic acid, glibenclamide and acarboseQ36053639
Clonidine potentiates the neuropathic pain-relieving action of MK-801 while preventing its neurotoxic and hyperactivity side effectsQ39448869
Redox modulation of T-type calcium channels in rat peripheral nociceptorsQ40787127
Peptides and the primary afferent nociceptorQ40911083
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception.Q40949695
Effect of alpha-lipoic acid on vascular responses and nociception in diabetic ratsQ43652993
Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxideQ43705779
Action potential waveform voltage-clamp commands reveal striking differences in calcium entry via low and high voltage activated calcium channelsQ44449497
Oxaliplatin acts on IB4-positive nociceptors to induce an oxidative stress-dependent acute painful peripheral neuropathyQ46175650
Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative studyQ46504418
Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatientsQ46651876
Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activityQ48357310
High-affinity zinc inhibition of NMDA NR1-NR2A receptorsQ48954602
Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants.Q51395959
A low voltage-activated, fully inactivating Ca channel in vertebrate sensory neuronesQ59075458
Reversible inhibition of NADPH-cytochrome P450 reductase by alpha-lipoic acidQ71780740
Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitroQ72608781
Mechanisms of neuropathic painQ79173262
A classification scheme for redox-based modifications of proteinsQ79572021
Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomersQ81416492
P433issue30
P407language of work or nameEnglishQ1860
P304page(s)9500-9509
P577publication date2009-07-01
P1433published inJournal of NeuroscienceQ1709864
P1476titleMolecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway
P478volume29