PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

scientific article

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00165.2008
P932PMC publication ID2643880
P698PubMed publication ID19028801
P5875ResearchGate publication ID23492700

P50authorBrian R WamhoffQ106703562
Brett R BlackmanQ106705156
Gary K OwensQ106705276
P2093author name stringUlf Eriksson
Stavros Topouzis
Christopher W Moehle
James A Thomas
Nicole E Hastings
Rebecca A Deaton
Yueting Shang
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Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cellsQ24531982
PDGF-D, a new protease-activated growth factorQ28186722
Effect of platelet-derived growth factor receptor-alpha and -beta blockade on flow-induced neointimal formation in endothelialized baboon vascular graftsQ73675149
Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic miceQ81349626
The pathogenesis of atherosclerosis: a perspective for the 1990sQ29547827
Molecular regulation of vascular smooth muscle cell differentiation in development and diseaseQ29615194
Role of platelet-derived growth factors in physiology and medicineQ29615222
A transforming growth factor-beta control element required for SM alpha-actin expression in vivo also partially mediates GKLF-dependent transcriptional repressionQ30311219
Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiationQ30311540
Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genesQ30432867
A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.Q30434820
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression.Q30435516
5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivoQ30435837
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.Q30439134
Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cellsQ30441514
Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.Q30442053
Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.Q30442993
Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory primingQ30444661
Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cellsQ30460026
Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesionsQ33916802
PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorQ33945092
Platelet-derived growth factor D: tumorigenicity in mice and dysregulated expression in human cancerQ34125870
Roles of PDGF in animal developmentQ34227429
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.Q34304925
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaquesQ34327535
Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction.Q34504663
Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly.Q34542211
Pathologic assessment of the vulnerable human coronary plaqueQ35583211
Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null miceQ35789286
The PDGF family: four gene products form five dimeric isoformsQ35811076
The role of shear stress in the pathogenesis of atherosclerosisQ35965518
Carotid bifurcation atherosclerosis. Quantitative correlation of plaque localization with flow velocity profiles and wall shear stressQ36618016
Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cellsQ40953884
Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesisQ42493807
Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell contentQ42578006
Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migrationQ43909343
Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promotersQ44923453
Platelet-derived growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cellsQ44980179
Platelet-derived growth factor-BB-induced human smooth muscle cell proliferation depends on basic FGF release and FGFR-1 activation.Q45206419
Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis.Q53859497
Endogenously elicited antibodies to platelet derived growth factor-BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol-fed rabbitQ73372272
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
atherosclerosisQ12252367
P304page(s)H442-52
P577publication date2008-11-21
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titlePDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns
P478volume296

Reverse relations

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