Regulation of ghrelin structure and membrane binding by phosphorylation

scientific article

Regulation of ghrelin structure and membrane binding by phosphorylation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.PEPTIDES.2008.02.001
P932PMC publication ID2413428
P698PubMed publication ID18343535
P5875ResearchGate publication ID5507893

P50authorBruce GaylinnQ43172719
P2093author name stringElizabeth Fox
Jianhua Liu
Eva Dehlin
Julianne J Sando
Samuel H Yun
Sandra Snyder
Cyrille Gineste
Leslie Willingham
Mario Geysen
P2860cites workGhrelin is a growth-hormone-releasing acylated peptide from stomachQ22010951
Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cellsQ24298483
Ghrelin is produced by the human erythroleukemic HEL cell line and involved in an autocrine pathway leading to cell proliferationQ24317092
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intakeQ28281470
Common structural basis for constitutive activity of the ghrelin receptor familyQ28283575
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.Q30439742
Acyl and total ghrelin are suppressed strongly by ingested proteins, weakly by lipids, and biphasically by carbohydratesQ30439748
Initial three-dimensional reconstructions of protein kinase C delta from two-dimensional crystals on lipid monolayersQ30443958
Activation of protein kinase C by short chain phosphatidylcholinesQ30462463
Activation of protein kinase C by lysophosphatidic acid: dependence on composition of phospholipid vesiclesQ30468722
Influence of lipid on the structure and phosphorylation of protein kinase C alpha substrate peptidesQ30471797
1H NMR structural analysis of human ghrelin and its six truncated analogsQ30666968
Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescentsQ30943330
Cell-penetrating peptides.Q33846582
N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolaeQ33948557
Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexiaQ33985070
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans.Q34095151
Membrane lipid microdomains and the role of PKCtheta in T cell activationQ34222554
Biological, physiological, pathophysiological, and pharmacological aspects of ghrelinQ35794412
Cell biology of the ghrelin receptorQ36383869
Measuring the binding of protein kinase C to sucrose-loaded vesiclesQ38352970
Charge-dependent translocation of the Trojan peptide penetratin across lipid membranes.Q40247472
Expression and function of the ghrelin axis, including a novel preproghrelin isoform, in human breast cancer tissues and cell linesQ40344901
Ghrelin and a novel preproghrelin isoform are highly expressed in prostate cancer and ghrelin activates mitogen-activated protein kinase in prostate cancerQ40344921
The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomasQ40374507
Ghrelin system in pancreatic AR42J cells: its ligand stimulation evokes calcium signalling through ghrelin receptors.Q40461457
Externalization of host cell protein kinase C during enteropathogenic Escherichia coli infectionQ40485173
Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processingQ40692602
Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.Q40840986
Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cellsQ42460970
Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epitheliaQ42526036
Structural analysis based on state-space modelingQ42842990
Circulating ghrelin levels in patients with inflammatory bowel diseaseQ42844932
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.Q42918384
Plasma ghrelin and desacyl ghrelin concentrations in renal failure.Q44192002
Ghrelin can bind to a species of high density lipoprotein associated with paraoxonaseQ44280952
Stimulatory effect of ghrelin on isolated porcine somatotropesQ44502663
Low Plasma Ghrelin Is Associated With Insulin Resistance, Hypertension, and the Prevalence of Type 2 DiabetesQ44599802
Ghrelin levels correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humansQ44690246
Ghrelin acts at the nucleus of the solitary tract to decrease arterial pressure in ratsQ44781986
Ghrelin degradation by serum and tissue homogenates: identification of the cleavage sitesQ44980840
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetesQ46430125
Conformational flexibility of the peptide hormone ghrelin in solution and lipid membrane bound: a molecular dynamics studyQ46858299
Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserineQ48347148
Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivoQ48629943
Quantitative analysis of protein far UV circular dichroism spectra by neural networksQ52423418
Phosphoinositide-specific phospholipase C-delta 1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphateQ67507881
Invasive human pituitary tumors express a point-mutated alpha-protein kinase-CQ72165930
Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesiclesQ72808746
Mutations in the preproghrelin/ghrelin gene associated with obesity in humansQ74364847
Central ghrelin modulates sympathetic activity in conscious rabbitsQ78460999
On the processing of proghrelin to ghrelinQ79271202
The ongoing saga of obestatin: is it a hormone?Q81152685
Circulating ghrelin levels in patients with various upper gastrointestinal diseasesQ81769278
P4510describes a project that usesImageQuantQ112270642
P433issue6
P921main subjectphosphorylationQ242736
P304page(s)904-911
P577publication date2008-02-13
P1433published inPeptidesQ7166533
P1476titleRegulation of ghrelin structure and membrane binding by phosphorylation
P478volume29

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cites work (P2860)
Q41851500Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis-A Hypothesis
Q28611550Ghrelin fluctuation, what determines its production?
Q57791096Ghrelin forms in the modulation of energy balance and metabolism
Q42596581Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization
Q30427744Inhibition of isoflurane-induced increase of cell-surface redistribution and activity of glutamate transporter type 3 by serine 465 sequence-specific peptides
Q28544962Integrating solid-state NMR and computational modeling to investigate the structure and dynamics of membrane-associated ghrelin
Q37393063Structure and physiological actions of ghrelin
Q36110171The antimicrobial activity of the appetite peptide hormone ghrelin
Q33629982The peptide hormone ghrelin binds to membrane-mimetics via its octanoyl chain and an adjacent phenylalanine.

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