Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction

scientific article

Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1210/ER.2007-0028
P8608Fatcat IDrelease_6ti5dfvgnvdntpgkjpmo2fpsj4
P932PMC publication ID2528845
P698PubMed publication ID18216218
P5875ResearchGate publication ID5635945

P50authorMoira O'BryanQ42892639
P2093author name stringBarry T Hinton
Leanne M Cotton
P2860cites workFgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determinationQ21092773
Structural basis for FGF receptor dimerization and activationQ22010544
Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificityQ22254157
Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerizationQ24290400
Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparinQ24290496
Cellular signaling by fibroblast growth factor receptorsQ24301087
A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motifQ24301723
Diverse forms of a receptor for acidic and basic fibroblast growth factorsQ24306588
The human fibroblast growth factor receptor genes: a common structural arrangement underlies the mechanisms for generating receptor forms that differ in their third immunoglobulin domainQ24306718
Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variantsQ24308772
Initial characterization of anosmin-1, a putative extracellular matrix protein synthesized by definite neuronal cell populations in the central nervous systemQ24310149
The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGFQ73642025
Male-to-female sex reversal in mice lacking fibroblast growth factor 9Q73719496
Orchidectomy induces a wave of apoptotic cell death in the epididymisQ74404886
Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumorsQ77412543
The Role of Prior Pubertal Development, Biochemical Markers of Testicular Maturation, and Genetics in Elucidating the Phenotypic Heterogeneity of Idiopathic Hypogonadotropic HypogonadismQ77481466
Gonadotropin-Releasing Hormone Deficiency in the Human (Idiopathic Hypogonadotropic Hypogonadism and Kallmann’s Syndrome): Pathophysiological and Genetic ConsiderationsQ77481731
Sry and sex determination: how lazy can it be?Q77671080
Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancerQ77827950
Expression and phosphorylation of mitogen-activated protein kinases during spermatogenesis and epididymal sperm maturation in miceQ78119244
Signal transduction by fibroblast growth factor receptorsQ78171822
Characterization of the FGF axis and identification of a novel FGFR1iiic isoform during prostate cancer progression in the TRAMP modelQ78703654
Analysis of prostatic bud induction by brief androgen treatment in the fetal rat urogenital sinusQ93543953
The blood-testis barrier in the rat and the physiological compartmentation of the seminiferous epitheliumQ93714075
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1Q24310428
A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding moleculesQ24311797
Molecular cloning and characterization of human FGF8 alternative messenger RNA formsQ24316049
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21Q24318639
Receptor specificity of the fibroblast growth factor familyQ24320178
Fibroblast growth factorsQ24542507
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptorsQ24554326
Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transductionQ24555661
Three-dimensional structure of human basic fibroblast growth factorQ24563295
Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivityQ24601740
Exon Switching and Activation of Stromal and Embryonic Fibroblast Growth Factor (FGF)-FGF Receptor Genes in Prostate Epithelial Cells Accompany Stromal Independence and MalignancyQ24602640
Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteinsQ24629903
Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathwaysQ24630500
Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndromeQ24646466
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptorsQ27628653
Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATPQ27641397
Cell signaling by receptor tyrosine kinasesQ27860474
A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGFQ28115298
The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion moleculesQ28118633
Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signalingQ28138237
Fibroblast growth factors, their receptors and signalingQ28140520
FGF-10 is expressed at low levels in the human prostateQ28144257
FGF9 is an autocrine and paracrine prostatic growth factor expressed by prostatic stromal cellsQ28199085
Identification of a new fibroblast growth factor receptor, FGFR5Q28202842
Biology of the syndecans: a family of transmembrane heparan sulfate proteoglycansQ28213234
Regulation of FGF8 expression by the androgen receptor in human prostate cancerQ28215985
Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologiesQ28236262
FGF5 as a regulator of the hair growth cycle: evidence from targeted and spontaneous mutationsQ28238356
Roles of FGF receptors in mammalian development and congenital diseasesQ28241041
FGF17 is an autocrine prostatic epithelial growth factor and is upregulated in benign prostatic hyperplasiaQ28260484
Structural and functional diversity in the FGF receptor multigene familyQ28265126
Three-Dimensional Structures of Acidic and Basic Fibroblast Growth FactorsQ28267322
Klotho converts canonical FGF receptor into a specific receptor for FGF23Q28272505
Keratinocyte growth factor is required for hair development but not for wound healingQ28273588
Fibroblast Growth Factors as Multifunctional Signaling FactorsQ28283514
Function of the syndecans--a family of cell surface proteoglycansQ28298962
Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factorQ28302620
Fibroblast growth factor signaling during early vertebrate developmentQ28305654
Promotion and attenuation of FGF signaling through the Ras-MAPK pathwayQ28312210
Identification of Sef, a novel modulator of FGF signallingQ28312228
The BMP family member Gdf7 is required for seminal vesicle growth, branching morphogenesis, and cytodifferentiationQ28504713
Fgfr2 is required for limb outgrowth and lung-branching morphogenesisQ28504835
FGF9 promotes survival of germ cells in the fetal testisQ28506269
Female development in mammals is regulated by Wnt-4 signallingQ28507770
Prostate development requires Sonic hedgehog expressed by the urogenital sinus epitheliumQ28509263
Functional compensation in Hedgehog signaling during mouse prostate developmentQ28509370
Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasisQ28512592
The mouse seminal vesicle shape mutation is allelic with Fgfr2Q28513248
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb inductionQ28513556
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiationQ28513573
FGF-10 plays an essential role in the growth of the fetal prostateQ28513689
Differential effects of transforming growth factor-beta1 on cellular proliferation in the developing prostateQ28564252
Androgen regulation of prostate morphoregulatory gene expression: Fgf10-dependent and -independent pathwaysQ28564384
The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogensQ28571234
Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2Q28581507
Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesisQ28585209
Roles for Nkx3.1 in prostate development and cancerQ28586102
Regulation of fibroblast growth factor-23 signaling by klothoQ28587100
Presence and Localization of a 30-kDa Basic Fibroblast Growth Factor-Like Protein in Rodent Testes*Q28589779
The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymisQ28589934
Erk MAP kinase regulates branching morphogenesis in the developing mouse kidneyQ28590780
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determinationQ28592010
Spontaneous mutation in mice provides new insight into the genetic mechanisms that pattern the seminal vesicles and prostate glandQ28594368
Anosmin-1 underlying the X chromosome-linked Kallmann syndrome is an adhesion molecule that can modulate neurite growth in a cell-type specific mannerQ28609163
Leydig cell function and its regulationQ33811866
FGFs, heparan sulfate and FGFRs: complex interactions essential for developmentQ33828280
Fibroblast growth factor-2.Q33845305
p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activationQ33855418
Kallmann's syndrome: is it always for life?Q33872650
A first-generation X-inactivation profile of the human X chromosomeQ33882906
Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancerQ33914163
Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors.Q33921403
Role of androgens and fibroblast growth factors in prostatic developmentQ34166848
Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domainsQ34245285
Genetic evidence equating SRY and the testis-determining factorQ34265507
Kallmann syndrome: towards molecular pathogenesisQ34289984
Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancersQ34291120
SRY and sex determination in mammalsQ34336806
Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genesQ34364985
A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1Q34440327
Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancerQ34481087
Role of heparan sulfate in fibroblast growth factor signalling: a structural viewQ34489556
Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypesQ34568239
Wnt4 action in gonadal development and sex determinationQ34569921
Sex-determining genes in mice: building pathways.Q34624950
Do different branching epithelia use a conserved developmental mechanism?Q34906883
Mouse models of male infertility.Q34932076
A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypesQ35042862
Tube or not tube: remodeling epithelial tissues by branching morphogenesisQ35046568
Fibroblast growth factors and their receptors in transitional cell carcinomaQ35051810
Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implicationsQ35071439
Hormonal, cellular, and molecular control of prostatic developmentQ35088639
The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy.Q35144575
A stain upon the silence: genes escaping X inactivationQ35193727
Syndecans: proteoglycan regulators of cell-surface microdomains?Q35611355
Interleukin-1alpha is a paracrine inducer of FGF7, a key epithelial growth factor in benign prostatic hyperplasiaQ35745901
One tissue, two fates: molecular genetic events that underlie testis versus ovary developmentQ35813860
Kallmann syndrome: fibroblast growth factor signaling insufficiency?Q35886618
Evolution of the Fgf and Fgfr gene familiesQ35913683
Diversity does make a difference: fibroblast growth factor-heparin interactionsQ38331346
Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cellsQ38331586
The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sitesQ38340236
Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer.Q38349736
Serum basic fibroblast growth factor in men with and without prostate carcinomaQ38479496
Sprouty2 is involved in male sex organogenesis by controlling fibroblast growth factor 9-induced mesonephric cell migration to the developing testis.Q38943874
Structure and function of the epididymisQ39506431
Anatomy of the prostate and morphogenesis of BPHQ40109868
The syndrome of anosmia with hypogonadotropic hypogonadism: a genetic study of 18 new families and a reviewQ40273774
Loss of Sef (similar expression to FGF) expression is associated with high grade and metastatic prostate cancer.Q40317257
Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterningQ40423955
The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymisQ40424665
The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.Q40506594
Association of the Signaling Adaptor FRS2 with Fibroblast Growth Factor Receptor 1 (Fgfr1) Is Mediated by Alternative Splicing of the Juxtamembrane DomainQ40765679
Discrete cell- and stage-specific localisation of fibroblast growth factors and receptor expression during testis developmentQ40780037
Functions of fibroblast growth factors in vertebrate developmentQ40918251
FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent diseaseQ40951616
Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cellsQ41077639
Ligand-induced transphosphorylation between different FGF receptorsQ41082448
The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathwayQ41296343
Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysisQ41360988
Stromal-epithelial interactions in the normal and neoplastic prostateQ41450475
Early stages of testicular differentiation in the ratQ41474769
Failure of Exogenous Androgen to Prevent Regression of the Initial Segments of the Rat Epididymis after Efferent Duct Ligation or Orchidectomy1Q41669793
Prostatic growth and development are regulated by FGF10.Q41679731
The Heparan Sulfate–Fibroblast Growth Factor Family: Diversity of Structure and FunctionQ41680432
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.Q41692233
Biphasic effect of basic fibroblast growth factor on 125I-human chorionic gonadotropin binding to cultured immature Leydig cellsQ41938138
Developmental expression of two murine fibroblast growth factor receptors, flg and bekQ42004982
Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cellsQ42278018
Development of cell types and of regional differences in the postnatal rat epididymisQ42443199
Basic fibroblast growth factor is a testicular germ cell product which may regulate Sertoli cell functionQ42509204
In vitro regulation of pig Sertoli cell growth and function: effects of fibroblast growth factor and somatomedin-C.Q42512322
Epithelial development in the rat ventral prostate, anterior prostate and seminal vesicleQ42523993
Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate.Q42527667
A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and SubstratesQ42599495
Regulation of FGF receptor-2 expression by transcription factor E2F-1.Q42797672
Elucidation of a signaling pathway induced by FGF-2 leading to uPA gene expression in NIH 3T3 fibroblastsQ42825425
Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblastsQ42827487
The human sef-a isoform utilizes different mechanisms to regulate receptor tyrosine kinase signaling pathways and subsequent cell fateQ42834568
The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3.Q43658446
Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolutionQ43678259
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafishQ43700219
Regulation of prostate branching morphogenesis by activin A and follistatinQ43716809
Phosphatidylinositol 3-kinase inhibition enhances human sperm motility.Q43723370
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling.Q43861037
Male development of chromosomally female mice transgenic for Sry.Q44051365
MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limbQ44453748
Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.Q44482913
Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour modelQ44557410
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signallingQ44701834
Basic fibroblast growth factor (bFGF) gene expression and protein production during pubertal development of the seminiferous tubule: follicle-stimulating hormone-induced Sertoli cell bFGF expressionQ44764646
Tyrosine phosphorylation of the a kinase anchoring protein 3 (AKAP3) and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonateQ45040797
The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progressionQ45077894
Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 geneQ45197397
A naturally occurring secreted form of fibroblast growth factor (FGF) receptor 1 binds basic FGF in preference over acidic FGFQ46269653
Analysis of growth factor and receptor mRNA levels during development of the rat seminal vesicle and prostateQ46319190
Fibroblast growth factor inhibits luteinizing hormone-stimulated androgen production by cultured rat testicular cellsQ46694090
Histology and fine structure of guinea pig seminal vesicle.Q46784529
FGFR-1 [corrected] signaling is involved in spermiogenesis and sperm capacitationQ46849810
Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic developmentQ47071537
Fgf signalling controls the dorsoventral patterning of the zebrafish embryoQ47073185
Sef is a spatial regulator for Ras/MAP kinase signalingQ47235238
Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryoQ47890677
Extracellular signal-regulated kinases modulate capacitation of human spermatozoaQ47984065
Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients.Q47998798
Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterningQ48005264
Heterogeneity in the mutations responsible for X chromosome-linked Kallmann syndromeQ48125476
The Addition of Mitogen-Activated Protein Kinase and p34cdc2Kinase Substrate Peptides Inhibits the Flagellar Motility of Demembranated Fowl SpermatozoaQ48595023
Anosmin-1, defective in the X-linked form of Kallmann syndrome, promotes axonal branch formation from olfactory bulb output neurons.Q48607771
Heparin binds endothelial cell growth factor, the principal endothelial cell mitogen in bovine brainQ48632706
Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndromeQ50336618
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.Q50336633
Presumptive pre-Sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in early testis differentiation.Q50699819
Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection--prevalence, types, sex distribution and reproductive relevanceQ50891467
Fibroblast growth factor receptor signaling through MEK-ERK is required for prostate bud inductionQ51765900
Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversalQ52059014
SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.Q52087362
The molecular genetic background of hereditary craniosynostoses and chondrodysplasiasQ52129226
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis.Q52171813
Functions of heparan sulfate proteoglycans in cell signaling during developmentQ35962679
The role of fibroblast growth factors and their receptors in prostate cancer.Q35991012
Molecular genetics of isolated hypogonadotropic hypogonadism and Kallmann syndrome.Q36049959
A window of opportunity: the diagnosis of gonadotropin deficiency in the male infantQ36053200
Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian developmentQ36064260
Syndecans: new kids on the signaling blockQ36073431
Fibroblast growth factor signaling in tumorigenesisQ36111404
Sex determination: a tale of two Sox genesQ36159529
Functions and regulations of fibroblast growth factor signaling during embryonic developmentQ36282338
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling.Q36336041
Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problemQ36553191
Apert syndrome: what prenatal radiographic findings should prompt its consideration?Q36564948
Branching morphogenesis in the prostate gland and seminal vesiclesQ36568783
Kallmann's syndrome, a neuronal migration defectQ36585188
Cloning of a fibroblast growth factor receptor 1 splice variant from Xenopus embryos that lacks a protein kinase C site important for the regulation of receptor activityQ36681691
Molecular pathogenesis of Kallmann's syndrome.Q36693337
Sex determination and gonadal development in mammalsQ36712740
Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse developmentQ36713660
Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsivenessQ36724475
Differential splicing in the extracellular region of fibroblast growth factor receptor 1 generates receptor variants with different ligand-binding specificitiesQ36807778
Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.Q36819391
Genetic insights into human isolated gonadotropin deficiency.Q36877075
The Fgf families in humans, mice, and zebrafish: their evolutional processes and roles in development, metabolism, and diseaseQ36961346
Development of the mammalian gonad: The fate of the supporting cell lineageQ37204561
Purification of a Growth Factor for Ovarian Cells from Bovine Pituitary GlandsQ37447613
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.Q37534320
Keratinocyte growth factor functions in epithelial induction during seminal vesicle developmentQ37558690
The heparin-binding (fibroblast) growth factor family of proteinsQ38286731
Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.Q38293129
Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexesQ38294596
Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization.Q38297297
Fibroblast growth factor receptor (FGFR) 3. Alternative splicing in immunoglobulin-like domain III creates a receptor highly specific for acidic FGF/FGF-1.Q38309173
Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostateQ38325648
The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptorsQ28609622
Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domainQ28609659
Fibroblast growth factor receptors: lessons from the genesQ28646382
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptorQ29616189
Signaling--2000 and beyondQ29617413
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genesQ29618455
Angiogenic factorsQ29620582
Cancer statistics, 2004Q29620739
p53 independent, region-specific epithelial apoptosis is induced in the rat epididymis by deprivation of luminal factorsQ30303991
Characterization of fibroblast growth factor receptors expressed in principal cells in the initial segment of the rat epididymisQ30310556
Growth factors and the epididymisQ30439502
Segment boundaries of the adult rat epididymis limit interstitial signaling by potential paracrine factors and segments lose differential gene expression after efferent duct ligationQ30443919
Identification, Expression, and Regulation of the Transcriptional Factor Polyomavirus Enhancer Activator 3, and its Putative Role in Regulating the Expression of Gamma-Glutamyl Transpeptidase mRNA-IV in the Rat Epididymis1Q30470699
Regulation of gamma-glutamyl transpeptidase catalytic activity and protein level in the initial segment of the rat epididymis by testicular factors: role of basic fibroblast growth factor.Q30471699
A gene expression screen in zebrafish embryogenesis.Q30772929
The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.Q30944660
Alternative splicing of fibroblast growth factor receptors in human prostate cancerQ31912970
Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brainQ33253201
Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer.Q33289739
Gene expression in the epididymis.Q33596721
Developmental and genetic disorders in spermatogenesisQ33640132
Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice.Q33787009
Regulation of apoptotic cell death in the rat epididymisQ73379830
Basic fibroblast growth factor levels in cancer cells and in sera of patients suffering from proliferative disorders of the prostateQ73409361
Mechanistic basis for catalytic activation of mitogen-activated protein kinase phosphatase 3 by extracellular signal-regulated kinaseQ73509756
Identification of Phosphorylated Proteins Associated with the Fibroblast Growth Factor Receptor Type I during EarlyXenopusDevelopmentQ52189141
Developmental and Hormonal Regulation of Transforming Growth Factor-α and Epidermal Growth Factor Receptor Gene Expression in Isolated Prostatic Epithelial and Stromal Cells*Q52190086
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryosQ52211686
Ductal budding and branching patterns in the developing prostateQ52216840
Purification and complementary DNA cloning of a receptor for basic fibroblast growth factorQ52245642
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal developmentQ52248354
Cell surface proteoglycan expression correlates with epithelial-mesenchymal interaction during tooth morphogenesisQ52249917
Role of fibroblast growth factor receptor signaling in prostate cancer cell survival.Q52544697
Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate.Q52552815
Ontogeny of GnRH and olfactory neuronal systems in man: novel insights from the investigation of inherited forms of Kallmann's syndrome.Q52561443
Extended and flexible domain solution structure of the extracellular matrix protein anosmin-1 by X-ray scattering, analytical ultracentrifugation and constrained modellingQ52658103
Cell- and stage-specific expression of basic FGF in the developing rat gonads.Q53732077
Hypogonadotropic eunuchoidism. I. Clinical study of the mode of inheritanceQ54148204
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferationQ54246457
Matthew-Wood syndrome: Report of two new cases supporting autosomal recessive inheritance and exclusion ofFGF10 andFGFR2Q57199602
Natural History of Early, Localized Prostate CancerQ57199844
Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoaQ57592485
Modular feedbackQ59006571
Sperm Maturation in Rabbit EpididymisQ59075867
Novel Fibroblast Growth Factor Receptor 1 Mutations in Patients with Congenital Hypogonadotropic Hypogonadism with and without AnosmiaQ60677985
Differential Localization of Fibroblast Growth Factor Receptor-i, -2, -3, and -4 in Fetal, Immature, and Adult Rat Testes1Q60923210
aFGF immunoreactivity in prostate cancer and its co-localization with bFGF and FGF8Q63966045
Sertoli cells from immature rats: In vitro stimulation of steroid metabolism by FSHQ67460489
Androgen binding protein (ABP) in fluids collected from the rete testis and cauda epididymidis of sexually mature and immature rabbits and observations on morphological changes in the epididymis following ligation of the ductuli efferentesQ67598520
Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shapeQ67954211
Basic fibroblast growth factor (bFGF) in rodent testis. Presence of bFGF mRNA and of a 30 kDa bFGF protein in pachytene spermatocytesQ68127241
Testicular regulation of epididymal protein secretionQ68147901
Hypogonadotropic eunuchoidism. II. Gonadal responsiveness to exogenous gonadotropinsQ68769735
XY female mice resulting from a heritable mutation in the primary testis-determining gene, TdyQ68921271
Morphogenesis of ductal networks in the mouse prostateQ69564996
An essential heparin-binding domain in the fibroblast growth factor receptor kinaseQ70619107
Heparin binding growth factors and the control of teratoma cell proliferationQ70669870
Expression of a truncated FGF receptor results in defective lens development in transgenic miceQ70935409
Effect of fibroblast growth factor-2 on Sertoli cells and gonocytes in coculture during the perinatal periodQ70983629
Characterization and androgen-dependence of proteins associated with luminal fluid and spermatozoa in the rat epididymisQ71368517
Studies on the Function of the Epididymis1Q71394673
The activity of the Ets transcription factor PEA3 is regulated by two distinct MAPK cascadesQ71536070
Induction of puberty in men by long-term pulsatile administration of low-dose gonadotropin-releasing hormoneQ71625585
Early effects of efferent ductule ligation on the proximal segment of the rat epididymisQ71707695
Regulation of protein tyrosine phosphorylation in human sperm by a calcium/calmodulin-dependent mechanism: identification of A kinase anchor proteins as major substrates for tyrosine phosphorylationQ71844276
Expression of fibroblast growth factors (FGFs) and FGF receptors in human prostateQ71927197
The junctional specializations of sertoli cells in the seminiferous epitheliumQ72242907
Effects of duct ligation on the fertilzing ability of spermatozoa from different regions of the rabbit epididymisQ72370519
Involvement of the conserved acidic amino acid domain of FGF receptor 1 in ligand-receptor interactionQ72572364
The androgen receptor in the testicular feminized (Tfm) mouse may be a product of internal translation initiationQ72780971
Luminal contents of the bovine epididymis under conditions of reduced spermatogenesis, luminal blockage and certain sperm abnormalitiesQ72804813
A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain IIIQ72930596
Regulation of protein-tyrosine phosphorylation and human sperm capacitation by reactive oxygen derivativesQ73024313
P433issue2
P304page(s)193-216
P577publication date2008-01-23
P13046publication type of scholarly workreview articleQ7318358
P1433published inEndocrine ReviewsQ3054007
P1476titleCellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction
P478volume29

Reverse relations

cites work (P2860)
Q33898822Analysis of male reproductive parameters in a murine model of mucopolysaccharidosis type I (MPS I).
Q33643328Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans
Q28066206Can mesenchymal stem cells improve spermatogonial stem cell transplantation efficiency?
Q54571394Characterization of FGF receptor expression in human neutrophils and their contribution to chemotaxis
Q37164165Circulating basic fibroblast growth factor in serum of gastric ulcers patient as a biomarker of wound severity.
Q35014892Common integration sites for MMTV in viral induced mouse mammary tumors
Q28590472Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling
Q53382829Effects of local and sustained release of FGF, IGF, and GH on germ cells in unilateral undescended testis in rats.
Q34696989Essential Roles of Androgen Signaling in Wolffian Duct Stabilization and Epididymal Cell Differentiation
Q43059410Expression and function of fibroblast growth factor 18 in the ovarian follicle in cattle
Q43263196Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer.
Q50625839FGF8-FGFR1 signaling acts as a niche factor for maintaining undifferentiated spermatogonia in the mouse
Q58713781FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells
Q64244477Fibroblast Growth Factor Family in the Progression of Prostate Cancer
Q35602057Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation
Q64279460Fibroblast growth factor 16 stimulates proliferation but blocks differentiation of rat stem Leydig cells during regeneration
Q48365195Fibroblast growth factor 2 (FGF2) is present in human spermatozoa and is related with sperm motility. The use of recombinant FGF2 to improve motile sperm recovery
Q92925829Fibroblast growth factor homologous factor 1 stimulates Leydig cell regeneration from stem cells in male rats
Q84552090Fibroblast growth factor receptor 3 is highly expressed in rarely dividing human type A spermatogonia
Q50876156Fibroblast growth factor, estrogen, and prolactin receptor features in different grades of prostatic adenocarcinoma in elderly men
Q37244728Fibroblast growth factor-2 autofeedback regulation in pituitary folliculostellate TtT/GF cells
Q45358465Fibroblast growth factor-2 regulation of sprouty and NR4A genes in bovine ovarian granulosa cells
Q61445694Fibroblast growth factor-5 promotes spermatogonial stem cell proliferation via ERK and AKT activation
Q36923642Fibroblast growth factors, old kids on the new block
Q47779891HUMAN IN-VITRO SPERMATOGENESIS FROM PLURIPOTENT STEM CELLS: IN NEED OF A STEPWISE DIFFERENTIATION PROTOCOL?
Q104481994Heparan sulfate fine-tunes stromal-epithelial communication in the prostate gland
Q26750385Involvement of Fibroblast Growth Factors and Their Receptors in Epididymo-Testicular Descent and Maldescent
Q34510150Isolation and gene expression analysis of single potential human spermatogonial stem cells.
Q38777987Lost in translation: The search for an in vitro screen for spermatogenic toxicity
Q26778995Mechanisms of fibroblast growth factor signaling in the ovarian follicle
Q47145544On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility
Q34870845Pathway Analysis Shows Association between FGFBP1 and Hypertension
Q33930831Plasticity of basal cells during postnatal development in the rat epididymis
Q28480870Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B
Q45173079Prostatic microenvironment in senescence: fibroblastic growth factors × hormonal imbalance
Q37994629Region-specific gene expression in the epididymis
Q36075002Research Resource: A Reference Transcriptome for Constitutive Androstane Receptor and Pregnane X Receptor Xenobiotic Signaling
Q34197301Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.
Q27315140RiboTag analysis of actively translated mRNAs in Sertoli and Leydig cells in vivo
Q34067693Role of postnatal expression of fgfr1 and fgfr2 in testicular germ cells on spermatogenesis and fertility in mice.
Q35617097Role of testicular luminal factors on Basal cell elongation and proliferation in the mouse epididymis
Q54171446Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations
Q39312108Sertoli-secreted FGF-2 induces PFKFB4 isozyme expression in mouse spermatogenic cells by activation of the MEK/ERK/CREB pathway.
Q89522269Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance
Q38139831Targeting fibroblast growth factor pathways in prostate cancer
Q30426591Testicular lumicrine factors regulate ERK, STAT, and NFKB pathways in the initial segment of the rat epididymis to prevent apoptosis
Q33597010The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathways
Q38025677The contribution of proteomics to understanding epididymal maturation of mammalian spermatozoa.
Q37168110The expression profiles of fibroblast growth factor 9 and its receptors in developing mice testes
Q28587752The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth
Q42406767The role of fibroblast growth factor receptor 2 (FGFR2) in differentiation of bovine spermatogonial stem cells (SCC).
Q54375617The role of fibroblast growth factors on the differentiation of vaginal epithelium of neonatal mice
Q26823032The roles of fibroblast growth factors in the testicular development and tumor
Q52601468Vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF-2) as potential regulators of seasonal reproductive processes in male European bison (Bison bonasus, Linnaeus 1758).
Q30429887p-MAPK1/3 and DUSP6 regulate epididymal cell proliferation and survival in a region-specific manner in mice

Search more.