pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src

scientific article

pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.9.4.1536
P932PMC publication ID362570
P698PubMed publication ID2471064

P2093author name stringS J Parsons
J T Parsons
L K Wilson
D K Luttrell
P2860cites workA novel viral oncogene with structural similarity to phospholipase CQ28307371
Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoterQ29614259
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.Q30448511
Amino Acid Alterations Within a Highly Conserved Region of the Rous Sarcoma Virus src Gene Product pp60src Inactivate Tyrosine Protein Kinase ActivityQ30449986
Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-srcQ30450435
Reduced tyrosine kinase specific activity is associated with hypophosphorylation of pp60c-src in cells infected with avian erythroblastosis virusQ30450893
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilityQ30452209
Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein.Q30452242
Activation of pp60c-src tyrosine kinase specific activity in tumor-derived Syrian hamster embryo cells.Q30457411
Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src proteinQ30463102
Mutations around the NG59 lesion indicate an active association of polyoma virus middle-T antigen with pp60c-src is required for cell transformationQ33879388
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylationQ33931404
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cellsQ34048204
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylationQ34166097
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virusQ34254297
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activityQ35589675
Activation of the transforming potential of p60c-src by a single amino acid changeQ35610574
The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinantQ36790275
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.Q36793338
Platelet tyrosine-specific protein phosphorylation is regulated by thrombinQ36844443
The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activityQ36862547
Overexpressed pp60c-src can induce focus formation without complete transformation of NIH 3T3 cellsQ36888885
N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src geneQ36895142
Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homologQ36903643
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma virusesQ36909345
Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblastsQ36937100
Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformationQ37523303
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factorQ37537225
Subcellular localization of pp60src in RSV-transformed cellsQ40140350
Reconstitution of the Rous sarcoma virus transforming protein pp60v-src into phospholipid vesiclesQ40649687
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming proteinQ40667798
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigenQ40669975
An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteinsQ41488933
Activation of the pp60c-src kinase during differentiation of monomyelocytic cells in vitroQ42273784
Altered phosphorylation and activation of pp60c-src during fibroblast mitosisQ42804505
The cellular src gene product regulates junctional cell-to-cell communicationQ42805146
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domainQ42808327
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-srcQ44049774
Oncogene-mediated multistep transformation of C3H10T1/2 cellsQ44806159
pp60c-src is a substrate for phosphorylation when cells are stimulated to enter cycleQ44966106
Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteinsQ45796833
Polyoma virus transforming protein associates with the product of the c-src cellular geneQ45798405
Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal growth factorQ45804706
The nucleotide sequence and the tissue-specific expression of Drosophila c-srcQ47072139
Sequence similarity of phospholipase C with the non-catalytic region of src.Q48099424
pp60c-src is developmentally regulated in the neural retinaQ60654496
Fetal Bovine Serum: A Multivariate StandardQ66961587
p60c-src activity detected in the chromaffin granule membraneQ68860356
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)1536-1544
P577publication date1989-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titlepp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src
P478volume9

Reverse relations

cites work (P2860)
Q30450210A protein that is highly related to GTPase-activating protein-associated p62 complexes with phospholipase C gamma
Q30468973Activation of Fyn tyrosine kinase upon secretagogue stimulation of bovine chromaffin cells
Q58134938Activation of Src in human breast tumor cell lines: elevated levels of phosphotyrosine phosphatase activity that preferentially recognizes the Src carboxy terminal negative regulatory tyrosine 530
Q53396671Activation of c-Src gene product in hepatocellular carcinoma is highly correlated with the indices of early stage phenotype.
Q44582560Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor
Q28298083Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor
Q30175350Cas mediates transcriptional activation of the serum response element by Src.
Q38109021Cellular functions regulated by phosphorylation of EGFR on Tyr845.
Q30472067Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells
Q30454300Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases
Q43649346Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
Q30450353Constitutive phosphorylation of the receptor for insulinlike growth factor I in cells transformed by the src oncogene
Q28236497Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation
Q40021748DNA synthesis induced by some but not all growth factors requires Src family protein tyrosine kinases.
Q30175829Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels
Q40342689Elevated Src activity promotes cellular invasion and motility in tamoxifen resistant breast cancer cells.
Q28139023Enhancement of tyrosyl phosphorylation and protein expression of eps8 by v-Src
Q62604103Epidermal Growth Factor-induced DNA Synthesis
Q41436659Functional interaction between the epidermal growth factor receptor and c‐Src kinase activity
Q40631092Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites
Q30463936Identification of the in vitro phosphorylation sites on Gs alpha mediated by pp60c-src
Q30442141Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase
Q40962053Integrin-mediated migration of murine B82L fibroblasts is dependent on the expression of an intact epidermal growth factor receptor
Q41326657Interaction between lck and syk family tyrosine kinases in Fc gamma receptor-initiated activation of natural killer cells
Q30194582Involvement of pp60c-src with two major signaling pathways in human breast cancer
Q33897202Kinase inhibitors in cancer therapy: a look ahead
Q30454480Mechanism of biological synergy between cellular Src and epidermal growth factor receptor
Q34224865Mechanisms of action of flavopiridol
Q36675443Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis
Q28323490Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulation
Q41075249Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor
Q41605774Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase
Q30441810Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene
Q30434083Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II.
Q30453620Phosphotyrosine (p-Tyr)-dependent and -independent mechanisms of p190 RhoGAP-p120 RasGAP interaction: Tyr 1105 of p190, a substrate for c-Src, is the sole p-Tyr mediator of complex formation
Q45204444Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent
Q30453944Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers
Q33631172Protein myristoylation in health and disease
Q28243770Regulation of SRC family kinases in human cancers
Q30176895Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling
Q46372936Requirement of inducible nitric-oxide synthase in lipopolysaccharide-mediated Src induction and macrophage migration
Q30310214STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor
Q46407291Src activation triggers capacitation and acrosome reaction but not motility in human spermatozoa
Q30307291Src family kinases and HER2 interactions in human breast cancer cell growth and survival
Q22253382Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression
Q30470153Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways
Q33959239Src in cancer: deregulation and consequences for cell behaviour
Q34481586Src inhibitors: genomics to therapeutics
Q34806104Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors
Q30360087Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection
Q41846085Targeting SRC and epidermal growth factor receptor in colorectal cancer: rationale and progress into the clinic.
Q37167029Targeting Src in breast cancer
Q30164215The C terminus of c-Src inhibits breast tumor cell growth by a kinase-independent mechanism
Q37066428The RON receptor tyrosine kinase promotes MSP-independent cell spreading and survival in breast epithelial cells
Q30450277The Sites of Phosphorylation by Protein Kinase C and an Intact SH2 Domain Are Required for the Enhanced Response to β-Adrenergic Agonists in Cells Overexpressing c-src
Q30176898The Src SH3 domain is required for DNA synthesis induced by platelet-derived growth factor and epidermal growth factor
Q42378470The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells
Q28210439The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin
Q26853018The molecular rationale of Src inhibition in colorectal carcinomas
Q44002704The presence of a single tyrosine residue at the carboxyl domain of vascular endothelial growth factor receptor-2/FLK-1 regulates its autophosphorylation and activation of signaling molecules
Q30438058Transactivating agonists of the EGF receptor require Tyr 845 phosphorylation for induction of DNA synthesis
Q30441879Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein
Q24803054Tyrosine kinase signalling in breast cancer: epidermal growth factor receptor and c-Src interactions in breast cancer
Q24648808Tyrosine phosphorylation of selected secretory carrier membrane proteins, SCAMP1 and SCAMP3, and association with the EGF receptor
Q30442121Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src
Q30448769c-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGF
Q30442226c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation
Q40090625c-Src trafficking and co-localization with the EGF receptor promotes EGF ligand-independent EGF receptor activation and signaling
Q30303932c-Src, receptor tyrosine kinases, and human cancer

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