The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

scientific article published on May 1986

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.58.2.468-474.1986
P932PMC publication ID252933
P698PubMed publication ID3009860

P2093author name stringB M Sefton
K Gould
J E Buss
M P Kamps
P2860cites workCharacterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src)Q24618435
n-Tetradecanoyl is the NH2-terminal blocking group of the catalytic subunit of cyclic AMP-dependent protein kinase from bovine cardiac muscleQ24629499
Identification of the NH2-terminal blocking group of calcineurin B as myristic acidQ28279541
Amino terminal myristylation of the protein kinase p60src, a retroviral transforming proteinQ28306986
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membraneQ28575831
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresisQ29547747
The role of protein kinase C in cell surface signal transduction and tumour promotionQ29618532
Transforming gene product of Rous sarcoma virus phosphorylates tyrosineQ29620005
Temperature-sensitive transformation by Rous sarcoma virus and temperature-sensitive protein kinase activityQ33912073
Two classes of fatty acid acylated proteins exist in eukaryotic cells.Q33931204
Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferaseQ34564166
A cellular protein that associates with the transforming protein of Rous sarcoma virus is also a heat-shock proteinQ35423531
Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src moleculesQ36211478
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylationQ36281307
Transit of pp60v-src to the plasma membraneQ36322218
Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylationQ36493768
Association of pp60src and src protein kinase activity with the plasma membrane of nonpermissive and permissive avian sarcoma virus-infected cellsQ36508814
Characterization of Rous sarcoma virus src gene products synthesized in vitroQ36526354
Processing of p60v-src to its myristylated membrane-bound formQ36895114
Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homologQ36903643
In vivo modification of retroviral gag gene-encoded polyproteins by myristic acidQ36905715
Antiserum specific for the carboxy terminus of the transforming protein of Rous sarcoma virusQ36926320
Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This ComplexQ36935658
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformationQ36947661
Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformationQ37523303
Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivoQ37601190
Myristyl amino-terminal acylation of murine retrovirus proteins: An unusual post-translational protein modificationQ37601276
Fine structural mapping of a critical NH2-terminal region of p60srcQ37680271
Specificity of fatty acid acylation of cellular proteinsQ42816118
Phosphorylation of p36 in vitro with pp60src. Regulation by Ca2+ and phospholipidQ43640077
Evidence that the src gene product of rous sarcoma virus is membrane associatedQ44731356
Nucleotide sequence of Rous sarcoma virusQ45798778
Novel localization of pp60src in rous sarcoma virus-transformed rat and goat cells and in chicken cells transformed by viruses rescued from these mammalian cellsQ45800232
The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosineQ45802887
Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene productQ45802905
Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosineQ45803653
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virusQ45804878
Transformation by Rous sarcoma virus: A cellular substrate for transformation-specific protein phosphorylation contains phosphotyrosineQ45805762
Purification of the RNA-directed DNA polymerase from avian myeloblastosis virus and its assay with polynucleotide templatesQ45826468
Protein kinase C phosphorylates pp60src at a novel site.Q48450716
Site-specific increased phosphorylation of pp60v-src after treatment of RSV-transformed cells with a tumor promoter.Q53542383
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.Q53552017
Identification of the NH2-terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domainQ70502219
In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinasesQ71653879
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)468-474
P577publication date1986-05-01
P1433published inJournal of VirologyQ1251128
P1476titleThe absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity
P478volume58

Reverse relations

cites work (P2860)
Q7199965932 Functional significance of myristoyl moiety in N-myristoyl proteins
Q36760038A major myristylated substrate of protein kinase C and protein kinase C itself are differentially regulated during murine B- and T-lymphocyte development and activation
Q52540067A member of the tomato Pto gene family confers sensitivity to fenthion resulting in rapid cell death.
Q36688971A myristylated form of the sea oncoprotein can transform chicken embryo fibroblasts
Q42597097A single mRNA, transcribed from an alternative, erythroid-specific, promoter, codes for two non-myristylated forms of NADH-cytochrome b5 reductase
Q40128092A single point mutation has pleiotropic effects on pp60v-src function
Q24301272A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin
Q34178415Acetylcholine receptor-associated 43K protein contains covalently bound myristate
Q38641081Acylation of viral and eukaryotic proteins
Q37629800Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition/amino acid consensus site for membrane association
Q34289461Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl protein after incorporation of an oxygen-substituted analog of myristic acid
Q67685045Antimyristoylation of GAG Proteins in Human T-Cell Lymphotropic and Human Immunodeficiency Viruses by N-Myristoyl Glycinal Diethylacetal
Q36533201Association of p60c-src with endosomal membranes in mammalian fibroblasts
Q42814545Biochemical and cytological changes associated with expression of deregulated pp60src in Xenopus oocytes
Q36671546CD45 tyrosine phosphatase activity and membrane anchoring are required for T-cell antigen receptor signaling
Q34362739Capsid protein VP4 of poliovirus is N-myristoylated
Q36795724Characterization of the gag/fusion protein encoded by the defective Duplan retrovirus inducing murine acquired immunodeficiency syndrome
Q33916780Conformation of a protein kinase C substrate NG(28-43), and its analog in aqueous and sodium dodecyl sulfate micelle solutions
Q34306937Controlling Signal Transduction with Synthetic Ligands
Q36382857Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae
Q30452209Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
Q30450251Differential Modulation of Plasminogen Activator Gene Expression by Oncogene-Encoded Protein Tyrosine Kinases
Q42808795Differential localization patterns of myristoylated and nonmyristoylated c-Src proteins in interphase and mitotic c-Src overexpresser cells
Q41601122Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology
Q41559089Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization
Q42477004Expression of enzymes of covalent protein modification during regulated and dysregulated proliferation of mammary epithelial cells: PKA, PKC and NMT.
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Q38989597Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy.
Q33675864Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation
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Q34369791Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells
Q28584740Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression
Q39578212Modification of proteins with covalent lipids
Q36529918Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase
Q44206563Myristic acid is coupled to a structural protein of polyoma virus and SV40.
Q34119774Myristoylation and membrane binding regulate c-Src stability and kinase activity
Q41269678Myristoylation of endothelial cell nitric oxide synthase is important for extracellular release of nitric oxide
Q41574954Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis.
Q24559906Myristoylation-dependent replication and assembly of human immunodeficiency virus 1
Q36675443Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis
Q36886315Myristylation is required for intracellular transport but not for assembly of D-type retrovirus capsids
Q36634970Myristylation of Pr60gag of the murine AIDS-defective virus is required to induce disease and notably for the expansion of its target cells
Q40101797Myristylation of pp60c-src is not required for complex formation with polyomavirus middle-T antigen
Q42857829N-myristoylation of p60src. Identification of a myristoyl-CoA:glycylpeptide N-myristoyltransferase in rat tissues
Q28138664N-myristoyltransferase
Q36916467N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity.
Q33567250Nonmyristoylated p60v-src fails to phosphorylate proteins of 115-120 kDa in chicken embryo fibroblasts
Q39547546Oncogenes and urological malignancies: implications for the future
Q36833765Phosphorylation of talin at tyrosine in Rous sarcoma virus-transformed cells
Q36864201Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus
Q36812340Preassembled capsids of type D retroviruses contain a signal sufficient for targeting specifically to the plasma membrane
Q45946956Purification and enzymatic characterization of pp60c-src from human platelets
Q37548959Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system
Q28615680Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells
Q44282147Replication of phi X174 dna with purified enzymes. I. Conversion of viral DNA to a supercoiled, biologically active duplex
Q36916539Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells
Q36531435Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle
Q30157893Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets
Q37387823Src-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites.
Q30450390Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins
Q28257266Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src
Q35163335Structure and expression of STK, a src-related gene in the simple metazoan Hydra attenuata
Q36701556Suppression of retroviral MA deletions by the amino-terminal membrane-binding domain of p60src
Q36787130The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus
Q39655733The covalent modification of eukaryotic proteins with lipid
Q34310513The disease-resistance gene Pto and the fenthion-sensitivity gene fen encode closely related functional protein kinases
Q36790275The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant
Q35859598The membrane-binding domain of the Rous sarcoma virus Gag protein
Q40648070The myristylation signal of p60v-src functionally complements the N-terminal fps-specific region of P130gag-fps
Q41453617The role of Src family kinases in the normal and neoplastic gastrointestinal tract.
Q39481220The role of myristoylation in the membrane association of the Lassa virus matrix protein Z.
Q36845819The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras
Q34555150The src protein contains multiple domains for specific attachment to membranes
Q30441879Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein
Q30450407Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene
Q34013237Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis
Q30442121Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60src
Q30450399pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src
Q37386016pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain

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