Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle

scientific article published on June 1, 1992

Specific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.117.5.1077
P8608Fatcat IDrelease_w5gxnrj5abeqtknynwbcfa22tu
P953full work available at URLhttps://europepmc.org/articles/PMC2289481
https://europepmc.org/articles/PMC2289481?pdf=render
P932PMC publication ID2289481
P698PubMed publication ID1374414
P5875ResearchGate publication ID274416312

P50authorMonica L VetterQ93170068
P2093author name stringJ. M. Bishop
A. D. Linstedt
R. B. Kelly
P2860cites workSynaptophysin is targeted to similar microvesicles in CHO and PC12 cellsQ26269968
rab3 is a small GTP-binding protein exclusively localized to synaptic vesiclesQ26269982
Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevatedQ28567013
The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membraneQ28575831
Phase separation of integral membrane proteins in Triton X-114 solutionQ29547600
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
c-src gene product in developing rat brain is enriched in nerve growth cone membranesQ33631204
Translocation of synapsin I in response to depolarization of isolated nerve terminalsQ34314079
The src protein contains multiple domains for specific attachment to membranesQ34555150
DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNAQ34581419
Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src moleculesQ36211478
p60c-src is complexed with a cellular protein in subcellular compartments involved in exocytosisQ36221104
Redistribution of synaptophysin and synapsin I during alpha-latrotoxin-induced release of neurotransmitter at the neuromuscular junctionQ36222565
Immunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cellsQ36224251
Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12Q36383379
Proteins of synaptic vesicles involved in exocytosis and membrane recyclingQ36494085
The neural network underlying locomotion in lamprey-synaptic and cellular mechanismsQ36503943
Polyomavirus middle T antigen downregulates junctional cell-to-cell communicationQ36835917
The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activityQ36862547
Processing of p60v-src to its myristylated membrane-bound formQ36895114
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma virusesQ36909345
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformationQ36947661
Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformationQ37523303
Neural tissues express high levels of the cellular src gene product pp60c-srcQ40674207
Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cellsQ41522239
Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatusQ41563890
The cellular src gene product regulates junctional cell-to-cell communicationQ42805146
Identification of platelet membrane proteins that interact with amino-terminal peptides of pp60c-srcQ42826369
Protein tyrosine kinase activity and its endogenous substrates in rat brain: a subcellular and regional surveyQ42837095
Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicityQ45077792
Intracellular localization of pp60c-src in human plateletsQ46219106
Characterization of synapsin I binding to small synaptic vesiclesQ48331820
Neurones express high levels of a structurally modified, activated form of pp60c-srcQ48462400
Localization and subcellular distribution of smg p25A, a ras p21-like GTP-binding protein, in rat brainQ48933292
A small GTP-binding protein dissociates from synaptic vesicles during exocytosisQ50337421
Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesiclesQ57979139
Identification of a 32K plasma membrane protein that binds to the myristylated amino-terminal sequence of p60v-srcQ59009147
p60c-src activity detected in the chromaffin granule membraneQ68860356
Specific and saturable binding of pp60v-src to plasma membranes: evidence for a myristyl-src receptorQ69353017
Fractionation of synaptophysin-containing vesicles from rat brain and cultured PC12 pheochromocytoma cellsQ70411606
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1077-1084
P577publication date1992-06-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleSpecific association of the proto-oncogene product pp60c-src with an intracellular organelle, the PC12 synaptic vesicle
P478volume117

Reverse relations

cites work (P2860)
Q36235816A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I alpha associates with synaptic vesicles and phosphorylates a subset of vesicle proteins.
Q33943966A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.
Q22008016ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.
Q41263724Activation of human pp60c-src
Q27863662Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization
Q30449907An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity
Q36533201Association of p60c-src with endosomal membranes in mammalian fibroblasts
Q30194001Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylation of tyrosine 527.
Q28508291CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission
Q33112093Cellugyrin, a novel ubiquitous form of synaptogyrin that is phosphorylated by pp60c-src
Q42808795Differential localization patterns of myristoylated and nonmyristoylated c-Src proteins in interphase and mitotic c-Src overexpresser cells
Q28140166Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I
Q57911573Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes
Q35834690Highly specific antibody to Rous sarcoma virus src gene product recognizes nuclear and nucleolar antigens in human cells
Q24554522Identification of a new Pyk2 target protein with Arf-GAP activity
Q40132138Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain
Q30194201Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I
Q57911562Lack of Palmitoylation Redirects p59Hckfrom the Plasma Membrane to p61Hck-positive Lysosomes
Q41336364Membrane association of the myristoylated alanine-rich C kinase substrate (MARCKS) protein. Mutational analysis provides evidence for complex interactions
Q30534452Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin
Q24323219Myristoylation and differential palmitoylation of the HCK protein-tyrosine kinases govern their attachment to membranes and association with caveolae
Q28289277Myristoylation-dependent and electrostatic interactions exert independent effects on the membrane association of the myristoylated alanine-rich protein kinase C substrate protein in intact cells
Q48317652Neuronal pp60c-src(+) in the developing chick spinal cord as revealed with anti-hexapeptide antibody
Q35176748Nonreceptor tyrosine protein kinase pp60c-src in spatial learning: synapse-specific changes in its gene expression, tyrosine phosphorylation, and protein-protein interactions
Q44362843Osteoclasts express high levels of p60c-src, preferentially on ruffled border membranes
Q41774224Osteoclasts express high levels of pp60c-src in association with intracellular membranes
Q50681563Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/lysosomes.
Q28243770Regulation of SRC family kinases in human cancers
Q24296720Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
Q34103644Selected glimpses into the activation and function of Src kinase
Q40855911Sorting and storage during secretory granule biogenesis: looking backward and looking forward
Q30176201Src interacts with dynamin and synapsin in neuronal cells
Q34230665Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum
Q43581716Src, Fyn, and Yes are not required for neuromuscular synapse formation but are necessary for stabilization of agrin-induced clusters of acetylcholine receptors.
Q39757870Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells
Q40708080Storage and release of neurotransmitters
Q36274033Substrate recognition by osteoclast precursors induces C-src/microtubule association.
Q30194837Suppression of c-Src Activity by C-Terminal Src Kinase Involves the c-Src SH2 and SH3 Domains: Analysis with Saccharomyces cerevisiae
Q36640176Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity
Q34360201Synaptic vesicle phosphoproteins and regulation of synaptic function
Q33112089Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells
Q33894824Synaptophysin regulates activity-dependent synapse formation in cultured hippocampal neurons
Q24601743Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release
Q34562995Tetraspan vesicle membrane proteins: synthesis, subcellular localization, and functional properties.
Q40485520The cell cycle and c-Src
Q24294813Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain
Q36342168Trafficking of an acylated cytosolic protein: newly synthesized p56(lck) travels to the plasma membrane via the exocytic pathway