Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.

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Proteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI. is …
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P6179Dimensions Publication ID1033502926
P356DOI10.1186/1471-2202-11-95
P932PMC publication ID2928238
P698PubMed publication ID20704702
P5875ResearchGate publication ID45639178

P2093author name stringTao Liu
Peng Xie
Ming Chang
Linsen Hu
Yihong Hu
Jinhua Piao
Yingjiu Zhang
Xing'an Li
P2860cites workThe alternative role of 14-3-3 zeta as a sweeper of misfolded proteins in disease conditionsQ48628183
The proteomics of sickle cell disease: profiling of erythrocyte membrane proteins by 2D-DIGE and tandem mass spectrometry.Q50747553
Immunocytochemical co-localization of the proteasome in ubiquitinated structures in neurodegenerative diseases and the elderly.Q53216133
In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodiesQ64764806
Cu/Zn superoxide dismutase-like immunoreactivity is present in Lewy bodies from Parkinson disease: a light and electron microscopic immunocytochemical studyQ72064008
Cu/Zn superoxide dismutase-like immunoreactivity in Lewy body-like inclusions of sporadic amyotrophic lateral sclerosisQ72520333
Chromatin condensation is not associated with apoptosisQ77229025
Subcellular fractionationQ79436481
Peptide fragment intensity statistical modelingQ80830941
Chaperone proteins identified from synthetic proteasome inhibitor-induced inclusions in PC12 cells by proteomic analysisQ81237748
Tubulin seeds alpha-synuclein fibril formationQ24291881
A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell DeathQ24297163
Parkin accumulation in aggresomes due to proteasome impairmentQ24308757
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levelsQ24671477
A simple technique for quantifying apoptosis in 96-well platesQ24810168
alpha-Synuclein shares physical and functional homology with 14-3-3 proteinsQ28139698
Superoxide dismutase--applications and relevance to human diseasesQ28198204
Inhibition of proteasomes induces accumulation, phosphorylation, and recruitment of HSP27 and alphaB-crystallin to aggresomesQ28211937
Aggresome formation and neurodegenerative diseases: therapeutic implicationsQ28265926
Protein aggregation and neurodegenerative diseaseQ28273600
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinaseQ28282891
A single polypeptide acts both as the beta subunit of prolyl 4-hydroxylase and as a protein disulfide-isomeraseQ28288295
Regional assignment of the human gene coding for a multifunctional polypeptide (P4HB) acting as the β-subunit of prolyl 4-hydroxylase and the enzyme protein disulfide isomerase to 17q25Q28296844
ER chaperones in mammalian development and human diseasesQ28300625
Proteomic changes of PC12 cells treated with proteasomal inhibitor PSIQ28569104
Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitinationQ28570666
Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradationQ28572388
Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5AQ28586364
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and agingQ29614783
The minimum information about a proteomics experiment (MIAPE)Q29615391
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.Q30312062
A proteomic survey of rat cerebral cortical synaptosomesQ31163203
Increased expression and altered subunit composition of proteasomes induced by continuous proteasome inhibition establish apoptosis resistance and hyperproliferation of Burkitt lymphoma cellsQ33285275
An update on data standards for gel electrophoresisQ33300248
Hepatitis B virus X protein suppressing adriamycin-induced apoptosis of HepG2 cellsQ33316883
Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's diseaseQ33318606
Specificity in intracellular protein aggregation and inclusion body formationQ33949081
Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCdelta proteolytic activation and mitochondrial translocationQ34214022
Tyrosine hydroxylase protein in Lewy bodies of parkinsonian and senile brainsQ42447562
Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide productionQ43658583
Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cellsQ43718632
Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cellsQ43758292
Ubiquitination of soluble and membrane-bound tyrosine hydroxylase and degradation of the soluble formQ43902847
Selective loss of 20S proteasome alpha-subunits in the substantia nigra pars compacta in Parkinson's diseaseQ44048965
Aggresome-related biogenesis of Lewy bodiesQ44242992
Immunohistochemical localization of 14.3.3 zeta protein in amyloid plaques in human spongiform encephalopathiesQ44295928
Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neuronsQ44308146
Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.Q44379856
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome functionQ44552114
Fine Structure and Biochemical Mechanisms Underlying Nigrostriatal Inclusions and Cell Death after Proteasome InhibitionQ44605313
Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells.Q44693092
Analysis of alpha-synuclein-associated proteins by quantitative proteomicsQ44964546
Generalized brain and skin proteasome inhibition in Huntington's diseaseQ45045405
A proteasomal stress response: pre-treatment with proteasome inhibitors increases proteasome activity and reduces neuronal vulnerability to oxidative injuryQ45138331
Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseasesQ45230472
VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegenerationQ45304146
Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD miceQ45305847
Angiotensin-(1-7) through AT receptors mediates tyrosine hydroxylase degradation via the ubiquitin-proteasome pathwayQ46138698
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysisQ46578554
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body diseaseQ46593989
Apoptosis and the conformational change of Bax induced by proteasomal inhibition of PC12 cells are inhibited by bcl-xL and bcl-2.Q46679719
Ultrasonic extraction and separation of anthraquinones from Rheum palmatum L.Q46749006
Proteasome inhibition: an early or late event in nitric oxide-induced neuronal death?Q46851350
Proteomic identification of novel proteins in cortical lewy bodiesQ48227693
An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonismQ48352469
Potential oxidative pathways of brain catecholaminesQ48410486
Neural heme oxygenase-1 expression in idiopathic Parkinson's diseaseQ48503937
Unfolding the role of chaperones and chaperonins in human diseaseQ34348757
Proteasomal dysfunction in sporadic Parkinson's diseaseQ34529359
Hassles with taking out the garbage: aggravating aggresomes.Q34637179
Substrate recognition by the protein disulfide isomerasesQ34692501
How the ubiquitin-proteasome system controls transcriptionQ35075758
Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.Q35157623
The role of the ubiquitin/proteasome system in cellular responses to radiationQ35208807
Ubiquitin-proteasome system and proteasome inhibition: new strategies in stroke therapy.Q35760480
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain.Q35869366
Roles of molecular chaperones in protein degradationQ36236478
Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70.Q36265331
Protein aggregation in the pathogenesis of familial and sporadic Parkinson's diseaseQ36278180
Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER.Q36323835
Expanding insights of mitochondrial dysfunction in Parkinson's disease.Q36404133
Protein quality control: the who's who, the where's and therapeutic escapesQ36432134
Protein misfolding disorders: pathogenesis and interventionQ36501365
Mechanisms of disease II: cellular protein quality control.Q36748835
Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machineryQ37072429
Proteomic identification of novel proteins associated with Lewy bodiesQ37146740
From hatching to dispatching: the multiple cellular roles of the Hsp70 molecular chaperone machineryQ37292909
Ubiquitin-dependent and -independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseasesQ37329440
Think locally: control of ubiquitin-dependent protein degradation in neuronsQ37349687
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangleQ37509229
Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF3, GADD153 and MAD1.Q38310990
Ubiquitin crosstalk connecting cellular processesQ38702950
Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson's diseaseQ39962524
Proteasome inhibition blocks caspase-8 degradation and sensitizes prostate cancer cells to death receptor-mediated apoptosisQ40036325
Effects of proteasome inhibitor, MG132, on proteasome activity and oxidative status of rat liverQ40128812
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregationQ40212840
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stressQ40262236
Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cellsQ40395753
Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinaseQ40427685
Identification of the protein disulfide isomerase family member PDIp in experimental Parkinson's disease and Lewy body pathologyQ40518177
Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.Q40556399
Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnoverQ40595923
Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomesQ40658264
Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing proteinQ40662036
Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathwayQ41064925
Neuropathology of Parkinson's diseaseQ41095404
Expression of K6W-ubiquitin in lens epithelial cells leads to upregulation of a broad spectrum of molecular chaperones.Q41822888
Histone carbonylation in vivo and in vitroQ42244057
P4510describes a project that usesImageQuantQ112270642
P304page(s)95
P577publication date2010-08-12
P1433published inBMC NeuroscienceQ15766477
P1476titleProteomic characterization of an isolated fraction of synthetic proteasome inhibitor (PSI)-induced inclusions in PC12 cells might offer clues to aggresomes as a cellular defensive response against proteasome inhibition by PSI.
P478volume11