Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

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Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis is …
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scholarly articleQ13442814

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P819ADS bibcode2009PNAS..106.2794A
P356DOI10.1073/PNAS.0812297106
P932PMC publication ID2634802
P698PubMed publication ID19188595
P5875ResearchGate publication ID23972682

P50authorKerstin Lindblad-TohQ6394763
Claire M WadeQ30530695
Sam LongQ58391926
Natasha J OlbyQ87893739
Daniel Martin KatzQ96086009
Tara BiagiQ114428868
Michele PerloskiQ117237980
P2093author name stringJeremy F Taylor
Gayle C Johnson
Joan R Coates
G Diane Shelton
Tomoyuki Awano
Dennis P O'Brien
Gary S Johnson
Shahnawaz Khan
Philip A March
Izabella Baranowska
P2860cites workAggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1Q22299419
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosisQ28131805
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injuryQ28511628
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutationQ29547561
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Function of the Greek key connection analysed using circular permutants of superoxide dismutase.Q30176552
Homozygosity for Asn86Ser mutation in the CuZn-superoxide dismutase gene produces a severe clinical phenotype in a juvenile onset case of familial amyotrophic lateral sclerosisQ33680279
Autosomal recessive adult-onset amyotrophic lateral sclerosis associated with homozygosity for Asp90Ala CuZn-superoxide dismutase mutation. A clinical and genealogical study of 36 patientsQ34397987
Efficient mapping of mendelian traits in dogs through genome-wide associationQ34695793
Familial amyotrophic lateral sclerosis. A subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cellsQ34706648
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Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosisQ36524814
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How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?Q36701609
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Amyotrophic lateral sclerosis models and human neuropathology: similarities and differencesQ37008443
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).Q41351491
Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogsQ46807335
Minute quantities of misfolded mutant superoxide dismutase-1 cause amyotrophic lateral sclerosisQ48177170
Structure, chromosomal location, and analysis of the canine Cu/Zn superoxide dismutase (SOD1) geneQ48291327
Degenerative myelopathy in 18 Pembroke Welsh Corgi dogsQ48716802
Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvementQ49023143
An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?Q51314897
A genome-wide association study of sporadic ALS in a homogenous Irish population.Q51899096
Degenerative myelopathy in an adult miniature poodle.Q53887222
Amyotrophic lateral sclerosis with mutation of the Cu/Zn superoxide dismutase gene (SOD1) in a patient with Down syndromeQ56994449
Motor nerve conduction velocity and latency in the dogQ66984138
Degenerative myelopathy in the aging German Shepherd dog: clinical and pathologic findingsQ67243043
Chronic degenerative radiculomyelopathy in the dog*Q67341911
German Shepherd dog myelopathy--a morphologic and morphometric studyQ67388007
Coexistence of dominant and recessive familial amyotrophic lateral sclerosis with the D90A Cu,Zn superoxide dismutase mutation within the same countryQ73789761
Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathyQ73936933
Degenerative myelopathy in a family of Siberian Husky dogsQ74060464
Amyotrophic lateral sclerosis-associated copper/zinc superoxide dismutase mutations preferentially reduce the repulsive charge of the proteinsQ80357661
Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron diseaseQ94029459
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectamyotrophic lateral sclerosisQ206901
genome-wide association studyQ1098876
P304page(s)2794-2799
P577publication date2009-02-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleGenome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis
P478volume106