Cognitive effects of cell-derived and synthetically derived Aβ oligomers

scientific article

Cognitive effects of cell-derived and synthetically derived Aβ oligomers is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.NEUROBIOLAGING.2009.11.007
P932PMC publication ID2895944
P698PubMed publication ID20031278
P5875ResearchGate publication ID40766768

P50authorKaren AsheQ6369493
Sylvain LesnéQ57587621
P2093author name stringDominic M Walsh
Mary Jo LaDu
Chunjiang Yu
Lisa Jungbauer
Miranda N Reed
James P Cleary
Alfred T Welzel
Mathew A Sherman
Jacki J Hofmeister
P2860cites workUtilization of a novel model of food reinforced behavior involving neuropeptide Y, insulin, 2-deoxy-d-glucose and naloxoneQ73554153
The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brainQ74290658
Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase asQ79851539
Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivoQ28131779
Evidence that production and release of amyloid beta-protein involves the endocytic pathwayQ28244336
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxinsQ29547593
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive functionQ29614851
A beta oligomers - a decade of discoveryQ29615152
Solution state characterization of amyloid beta-derived diffusible ligandsQ33266914
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesisQ34166792
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during agingQ35754595
The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention.Q36295340
Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformationQ37119890
Amyloid-beta oligomers are inefficiently measured by enzyme-linked immunosorbent assayQ40404080
Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrusQ42568400
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell cultureQ42805272
Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta(1-42) injections in the rat.Q44189359
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomersQ48326021
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor proteinQ48342880
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimersQ48654859
Neurotoxic protein oligomers--what you see is not always what you get.Q48708958
ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.Q49149877
Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.Q53248798
P433issue10
P304page(s)1784-1794
P577publication date2010-01-19
P1433published inNeurobiology of AgingQ7002141
P1476titleCognitive effects of cell-derived and synthetically derived Aβ oligomers
P478volume32

Reverse relations

cites work (P2860)
Q90375051A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
Q90628076A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies
Q27010785A window into the heterogeneity of human cerebrospinal fluid Aβ peptides
Q89861110APP Osaka Mutation in Familial Alzheimer's Disease-Its Discovery, Phenotypes, and Mechanism of Recessive Inheritance
Q91710120Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer's Disease
Q30535426Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation
Q38026984Alzheimer's disease Aβ assemblies mediating rapid disruption of synaptic plasticity and memory.
Q37636545Alzheimer's disease: synaptic dysfunction and Abeta
Q28544876Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits
Q47113449Amino-Terminal β-Amyloid Antibody Blocks β-Amyloid-Mediated Inhibition of the High-Affinity Choline Transporter CHT.
Q47990795Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells
Q34567280Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation
Q35533112Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit
Q37690332Amyloid β-protein oligomers and Alzheimer's disease
Q46625235Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Q37361564Amyloid-β oligomers regulate the properties of human neural stem cells through GSK-3β signaling
Q37286244Assessing the Effects of Acute Amyloid β Oligomer Exposure in the Rat.
Q56342045Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons
Q30539133Brain amyloid-β oligomers in ageing and Alzheimer's disease
Q26862630Breaking the Code of Amyloid-β Oligomers
Q39330851Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A 2 and synapse damage
Q37051726Correlation of specific amyloid-β oligomers with tau in cerebrospinal fluid from cognitively normal older adults
Q35191297Di-tyrosine cross-link decreases the collisional cross-section of aβ peptide dimers and trimers in the gas phase: an ion mobility study
Q35013344Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.
Q40893495Endocytic pathways mediating oligomeric Abeta42 neurotoxicity.
Q92070015Functional Amyloids and their Possible Influence on Alzheimer Disease
Q36605311Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice
Q37295754High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain
Q35813445High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification
Q27497796IVIg protects the 3xTg-AD mouse model of Alzheimer’s disease from memory deficit and Aβ pathology
Q48113629Impact of amyloid-beta changes on cognitive outcomes in Alzheimer's disease: analysis of clinical trials using a quantitative systems pharmacology model.
Q35646336Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons
Q38121070Is abeta a sufficient biomarker for monitoring anti-abeta clinical studies? A critical review.
Q38543419Lipids in Amyloid-β Processing, Aggregation, and Toxicity
Q46518657Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.
Q36666929Mesenchymal Stem Cells Preserve Working Memory in the 3xTg-AD Mouse Model of Alzheimer's Disease
Q36824513Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease
Q35925948Monomeric ß-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons
Q34125360Natural amyloid-β oligomers acutely impair the formation of a contextual fear memory in mice
Q38619618Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer's disease.
Q46814312Novel 5-aryloxypyrimidine SEN1576 as a candidate for the treatment of Alzheimer's disease
Q38794219Oligomeropathies and pathogenesis of Alzheimer and Parkinson's diseases.
Q42021752Passive anti-amyloid immunotherapy in Alzheimer's disease: What are the most promising targets?
Q36187149Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease
Q37729219Potential Neuroprotective Effects of Adiponectin in Alzheimer's Disease
Q35826425Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
Q46943581Republished: the role of amyloid β in the pathogenesis of Alzheimer's disease
Q35663419Soluble Aβ oligomer production and toxicity
Q35643397Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Q52568535Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.
Q38549882Structural, morphological, and functional diversity of amyloid oligomers
Q41894180Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology
Q41896658Structure-dependent effects of amyloid-β on long-term memory in Lymnaea stagnalis
Q45991189Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.
Q27320084Tailoring the antibody response to aggregated Aß using novel Alzheimer-vaccines
Q26822002Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer's disease immunotherapeutics
Q34792043Targets for AD treatment: conflicting messages from γ-secretase inhibitors
Q48262149Tau immunotherapy modulates both pathological tau and upstream amyloid pathology in an Alzheimer's disease mouse model.
Q34720146Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway
Q54977832The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.
Q46368794The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.
Q37774042The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?
Q34054680The intersection of amyloid beta and tau at synapses in Alzheimer's disease
Q36719033The neurodegeneration in Alzheimer disease and the prion protein
Q37979641The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Q34317403Therapeutic molecules and endogenous ligands regulate the interaction between brain cellular prion protein (PrPC) and metabotropic glutamate receptor 5 (mGluR5).
Q38265644Toxic oligomer species of amyloid-β in Alzheimer's disease, a timing issue.
Q38275791Viral capsid assembly as a model for protein aggregation diseases: Active processes catalyzed by cellular assembly machines comprising novel drug targets
Q36981528β-Amyloid oligomers in aging and Alzheimer's disease

Search more.