Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

scientific article published on 4 June 2015

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2015.05.021
P932PMC publication ID4494129
P698PubMed publication ID26051935
P5875ResearchGate publication ID277893980

P50authorKaren AsheQ6369493
Carrie M WilmotQ42119431
P2093author name stringPeng Liu
Wei Qiang
Joanna L Jankowsky
Marianne K O Grant
Kathleen R Zahs
Colleen L Forster
Samantha L Shapiro
Miranda N Reed
James P Cleary
Angie C A Chiang
Linda A Kotilinek
John H Reichl
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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.Q46380915
Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice.Q46765311
Symposium overview: the use of delayed matching-to-sample procedures in studies of short-term memory in animals and humansQ48381176
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumabQ48852013
Grape seed polyphenolic extract specifically decreases aβ*56 in the brains of Tg2576 miceQ49067502
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Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.Q53274559
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
Neuropathological alterations in Alzheimer diseaseQ27003314
Out-of-register  -sheets suggest a pathway to toxic amyloid aggregatesQ27675366
Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrilsQ27677945
Atomic View of a Toxic Amyloid Small OligomerQ27677948
Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain TissueQ27679935
Modeling an in-register, parallel "iowa" aβ fibril structure using solid-state NMR data from labeled samples with rosettaQ27697071
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaquesQ29028192
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisQ29547501
APP processing and synaptic functionQ29615873
Structural classification of toxic amyloid oligomersQ30484255
Cognitive effects of cell-derived and synthetically derived Aβ oligomersQ30495253
Brain amyloid-β oligomers in ageing and Alzheimer's diseaseQ30539133
Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.Q31840691
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.Q33292445
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout lifeQ33292558
Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formationQ33673470
Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's diseaseQ33707872
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanismQ34346440
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease.Q34656208
Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brainQ35063033
Solid-state NMR studies of amyloid fibril structureQ35327629
Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer ProfileQ35577702
Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomersQ36178075
Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's diseaseQ36855702
Dissecting phenotypic traits linked to human resilience to Alzheimer's pathologyQ37043088
Plaque-bearing mice with reduced levels of oligomeric amyloid-beta assemblies have intact memory function.Q37180168
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse modelQ37259695
Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenanceQ37352312
Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brains.Q37432185
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose studyQ37699953
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothesQ37979641
P433issue11
P304page(s)1760-1771
P577publication date2015-06-04
P1433published inCell ReportsQ5058165
P1476titleQuaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration
P478volume11

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