Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

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Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.NEUROBIOLAGING.2008.07.021
P8608Fatcat IDrelease_tvtnyk355vetpg6t7m4qowyzwy
P932PMC publication ID2909664
P698PubMed publication ID18771816
P5875ResearchGate publication ID23237940

P50authorGunnar K. GourasQ37374939
Estibaliz Capetillo-ZarateQ79758990
P2093author name stringTeresa A Milner
Michael T Lin
Reisuke H Takahashi
P2860cites workCorrelative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brainQ28137790
Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APPQ28592685
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Intracellular amyloid-beta in Alzheimer's diseaseQ29615626
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse modelQ29617937
Alzheimer disease models and human neuropathology: similarities and differencesQ30499574
Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's diseaseQ32028060
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta miceQ33252237
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesQ34452028
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's diseaseQ34509753
Synaptic slaughter in Alzheimer's diseaseQ35595427
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathologyQ35747757
Intraneuronal Abeta42 accumulation in human brain.Q35793325
Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's diseaseQ36196976
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathologyQ36724967
Review on the APP/PS1KI mouse model: intraneuronal Abeta accumulation triggers axonopathy, neuron loss and working memory impairmentQ37053943
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.Q39173722
Hippocampal alpha2a-adrenergic receptors are located predominantly presynaptically but are also found postsynaptically and in selective astrocytesQ39758463
Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.Q42059767
Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseaseQ42474769
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrilsQ43718666
Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndromeQ43906174
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic miceQ44182586
Early intraneuronal Abeta deposition in the hippocampus of APP transgenic miceQ44289387
Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasomeQ45007178
Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's diseaseQ45153471
Oligomerization of Alzheimer's beta-amyloid within processes and synapses of cultured neurons and brain.Q47798328
Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic miceQ48196554
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic miceQ48242315
Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.Q48366612
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model miceQ48408205
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.Q48439872
Intraneuronal Abeta42 accumulation in Down syndrome brainQ48443635
A conformation- and phosphorylation-dependent antibody recognizing the paired helical filaments of Alzheimer's disease.Q48540026
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.Q48577748
The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic miceQ48690756
Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic miceQ48846848
Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndromeQ48945429
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.Q51996386
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.Q53264641
p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.Q53594164
Inter-laboratory comparison of neuropathological assessments of β-amyloid protein: a study of the BrainNet Europe consortiumQ59690267
P433issue7
P921main subjectAlzheimer's diseaseQ11081
P304page(s)1145-1152
P577publication date2008-09-03
P1433published inNeurobiology of AgingQ7002141
P1476titleCo-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses
P478volume31

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cites work (P2860)
Q35353667AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly
Q50420723AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy
Q37618817Abnormal interaction of oligomeric amyloid-β with phosphorylated tau: implications to synaptic dysfunction and neuronal damage
Q35223831Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
Q34570846Accumulation of intraneuronal β-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses
Q92510463Aging, Metabolism, Synaptic Activity, and Aβ in Alzheimer's Disease
Q38532705Alzheimer's Disease, Drosophila melanogaster and Polyphenols.
Q35899503Alzheimer's disease: a clinical practice-oriented review
Q28087158Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities
Q48884122Beta-amyloid induced changes in A-type K⁺ current can alter hippocampo-septal network dynamics.
Q36817618Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration
Q38350075Cellular factors modulating the mechanism of tau protein aggregation
Q33948010Computational study of hippocampal-septal theta rhythm changes due to β-amyloid-altered ionic channels
Q36342011Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.
Q98196923Defining and predicting transdiagnostic categories of neurodegenerative disease
Q36691716Development of new fusion proteins for visualizing amyloid-β oligomers in vivo
Q55314136Divergent topological networks in Alzheimer's disease: a diffusion kurtosis imaging analysis.
Q30497246Effects of synaptic modulation on beta-amyloid, synaptophysin, and memory performance in Alzheimer's disease transgenic mice.
Q36137237Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses
Q38227862Glia and zinc in ageing and Alzheimer's disease: a mechanism for cognitive decline?
Q35598903Graph theoretic analysis of structural connectivity across the spectrum of Alzheimer's disease: The importance of graph creation methods
Q42219931Heterogeneous Association of Alzheimer's Disease-Linked Amyloid-β and Amyloid-β Protein Precursor with Synapses
Q55377473How to Build a Functional Connectomic Biomarker for Mild Cognitive Impairment From Source Reconstructed MEG Resting-State Activity: The Combination of ROI Representation and Connectivity Estimator Matters.
Q41849339Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice
Q34043165Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
Q37969262Interaction between pathogenic proteins in neurodegenerative disorders
Q53324250Interaction between α-synuclein and other proteins in neurodegenerative disorders.
Q39236779Interactions of pathological proteins in neurodegenerative diseases
Q42465835Intracellular accumulation of amyloid-β (Aβ) protein plays a major role in Aβ-induced alterations of glutamatergic synaptic transmission and plasticity.
Q27307787Intraneuronal Aβ accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3.
Q35646336Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons
Q35860859Isolation of synaptic terminals from Alzheimer's disease cortex
Q93013693Kv1.3 Channel as a Key Therapeutic Target for Neuroinflammatory Diseases: State of the Art and Beyond
Q33600113MEG Beamformer-Based Reconstructions of Functional Networks in Mild Cognitive Impairment
Q47280369Memantine for the Treatment of Dementia: A Review on its Current and Future Applications.
Q38195641Microglia receptors and their implications in the response to amyloid β for Alzheimer's disease pathogenesis
Q51029900Neurofibrillary Tangles of Aβx-40 in Alzheimer's Disease Brains.
Q38297925Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease.
Q32178128Neuroprotection by IFN-γ via astrocyte-secreted IL-6 in acute neuroinflammation
Q34544243Oligomeric Aβ-induced synaptic dysfunction in Alzheimer's disease
Q38832929Overexpression of Heme Oxygenase 1 Impairs Cognitive Ability and Changes the Plasticity of the Synapse
Q36873070Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology
Q99585475Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models
Q39163007Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease
Q41564705Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity
Q38876654Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.
Q26799870Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease
Q58780923Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
Q40277605Selective impairment of hippocampus and posterior hub areas in Alzheimer's disease: an MEG-based multiplex network study
Q34639435Single-subject grey matter graphs in Alzheimer's disease
Q34028039Synapses, synaptic activity and intraneuronal abeta in Alzheimer's disease
Q36468755Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases
Q50440796Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations.
Q30491040Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations
Q35035669Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease
Q28577234Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites
Q37684106Tau protein modifications and interactions: their role in function and dysfunction
Q51026158The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease.
Q34765883αν and β1 Integrins mediate Aβ-induced neurotoxicity in hippocampal neurons via the FAK signaling pathway