A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk

scientific article

A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1000694874
P356DOI10.1038/SJ.BJC.6605763
P932PMC publication ID2920017
P698PubMed publication ID20628393
P5875ResearchGate publication ID45185631

P50authorAndrew H. SimsQ39065426
Richard MeehanQ42846183
David HarrisonQ56737485
Jean A QuinnQ63366499
P2093author name stringJ Li
E E Evans
S P Langdon
E Katz
S Dubois-Marshall
E S Smith
M Edward
D Faratian
P2860cites workBioconductor: open software development for computational biology and bioinformaticsQ21194861
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cellsQ24290151
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cellsQ24317705
Significance analysis of microarrays applied to the ionizing radiation responseQ24606608
MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional cultureQ24646310
AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonistQ24652842
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The EGF receptor family: spearheading a merger of signaling and therapeuticsQ28289369
X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimizationQ80980462
Keratinocyte regulation of TGF-beta and connective tissue growth factor expression: a role in suppression of scar tissue formationQ81522497
Breaking down EMTQ81556375
Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristicsQ28751743
Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane culturesQ29547700
Tissue microarrays for high-throughput molecular profiling of tumor specimensQ29618675
beadarray: R classes and methods for Illumina bead-based data.Q31116642
Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivoQ33510688
Growth factor receptor-bound protein-7 (Grb7) as a prognostic marker and therapeutic target in breast cancerQ33676758
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammationQ34562439
HER-2 and topoisomerase II as predictors of response to chemotherapyQ34747499
An immunoreceptor tyrosine activation motif in the mouse mammary tumor virus envelope protein plays a role in virus-induced mammary tumorsQ35024308
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumorsQ35906418
Modelling glandular epithelial cancers in three-dimensional culturesQ36251934
Activation of multiple cancer-associated genes at the ERBB2 amplicon in breast cancerQ36443026
SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphomaQ36445884
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.Q36667053
American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancerQ36678853
The many faces of ITAMs.Q36695974
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.Q37459500
The SH2 domain protein GRB-7 is co-amplified, overexpressed and in a tight complex with HER2 in breast cancerQ37630052
The genomic profile of HER2-amplified breast cancers: the influence of ER statusQ38360582
Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells.Q39841601
Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinasesQ39882808
GRB-7 facilitates HER-2/Neu-mediated signal transduction and tumor formationQ40071931
The Shb signalling scaffold binds to and regulates constitutive signals from the Epstein-Barr virus LMP2A membrane proteinQ40169132
Isoforms of Wilms' tumor suppressor gene (WT1) have distinct effects on mammary epithelial cellsQ40198105
RNA interference-based functional dissection of the 17q12 amplicon in breast cancer reveals contribution of coamplified genesQ40278421
Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cellsQ40326039
Dangers of using "optimal" cutpoints in the evaluation of prognostic factorsQ40752297
C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancerQ42604307
Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells.Q42806816
Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformationQ42828149
The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodentsQ44453360
Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.Q45917372
A 38-gene expression signature to predict metastasis risk in node-positive breast cancer after systemic adjuvant chemotherapy: a genomic substudy of PACS01 clinical trialQ46236782
Automated subcellular localization and quantification of protein expression in tissue microarrays.Q52030096
Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.Q53347753
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectampliconQ2844457
P304page(s)401-410
P577publication date2010-07-13
P1433published inBritish Journal of CancerQ326309
P1476titleA gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk
P478volume103

Reverse relations

cites work (P2860)
Q34010823A new class of protein cancer biomarker candidates: differentially expressed splice variants of ERBB2 (HER2/neu) and ERBB1 (EGFR) in breast cancer cell lines
Q51136450Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation.
Q33828295An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer
Q41498719Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.
Q57031218CRISPR deletion of MIEN1 in breast cancer cells
Q34625171Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.
Q36486054Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.
Q57390777DNA Methylation Profiling of Breast Cancer Cell Lines along the Epithelial Mesenchymal Spectrum-Implications for the Choice of Circulating Tumour DNA Methylation Markers
Q36758884Dissecting GRB7-mediated signals for proliferation and migration in HER2 overexpressing breast tumor cells: GTP-ase rules
Q41577652Down-regulation of C35 decreased the cell viability and migration of breast ductal carcinoma cells.
Q92502600Drosophila p53 directs nonapoptotic programs in postmitotic tissue
Q90266976Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis
Q38949355Enhanced expression of retinoic acid receptor alpha (RARA) induces epithelial-to-mesenchymal transition and disruption of mammary acinar structures
Q34066386GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines
Q57017236Identification of the copy number variant biomarkers for breast cancer subtypes
Q91943722Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells
Q89519067Inhibition of the deubiquitinase USP10 induces degradation of SYK
Q35396741Long-term culture of human breast cancer specimens and their analysis using optical projection tomography.
Q37688163MIEN1 drives breast tumor cell migration by regulating cytoskeletal-focal adhesion dynamics
Q36214196MIEN1 promotes oral cancer progression and implicates poor overall survival
Q35953723MIEN1, a novel interactor of Annexin A2, promotes tumor cell migration by enhancing AnxA2 cell surface expression
Q34582195MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1.
Q90461747Migration and Invasion Enhancer 1 Is an NF-ĸB-Inducing Gene Enhancing the Cell Proliferation and Invasion Ability of Human Prostate Carcinoma Cells In Vitro and In Vivo
Q39557228Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors
Q34161161Mouse mammary tumor virus molecular biology and oncogenesis
Q100559757Pan-cancer driver copy number alterations identified by joint expression/CNA data analysis
Q24305028Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis
Q39586702Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells
Q55342016SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4+ T Lymphocytes.
Q28484489Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif
Q41084526The Transcriptional Landscape of p53 Signalling Pathway
Q37111154The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells
Q84594497Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer