| scholarly article | Q13442814 |
| P50 | author | Robert L. Geahlen | Q42692859 |
| P2093 | author name string | Qing Zhou | |
| Xiaoying Zhang | |||
| Bethany M Alicie | |||
| Ulka Shrikhande | |||
| P2860 | cites work | The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells | Q24290151 |
| The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells | Q24317705 | ||
| Cortactin signalling and dynamic actin networks | Q24528115 | ||
| Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia | Q24651552 | ||
| The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression | Q24801633 | ||
| Tyrosine kinase SYK: essential functions for immunoreceptor signalling | Q28145413 | ||
| Cortactin: coupling membrane dynamics to cortical actin assembly | Q28199365 | ||
| Syk expression and novel function in a wide variety of tissues | Q28202066 | ||
| Epigenetic silencing of novel tumor suppressors in malignant melanoma | Q28277211 | ||
| Physical and functional association of cortactin with Syk in human leukemic cell line K562 | Q28279379 | ||
| Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323 | Q28291812 | ||
| Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase | Q28506637 | ||
| Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr | Q28507457 | ||
| Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine | Q28626542 | ||
| Rho GTPases and their effector proteins | Q29547740 | ||
| FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly | Q29616029 | ||
| Cortactin is required for integrin-mediated cell spreading | Q30160007 | ||
| Cortactin is necessary for E-cadherin-mediated contact formation and actin reorganization | Q30443460 | ||
| Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3 | Q30448362 | ||
| Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization | Q31838023 | ||
| Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells | Q33209193 | ||
| Cadherins and their connections: adhesion junctions have broader functions. | Q33744981 | ||
| Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases. | Q33836812 | ||
| Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo | Q34103311 | ||
| Cadherin and catenin alterations in human cancer | Q34128162 | ||
| Syk, a protein-tyrosine kinase, suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells | Q34164078 | ||
| Vav proteins, adaptors and cell signaling. | Q34405552 | ||
| Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase | Q34564878 | ||
| Inactivation of the E-cadherin-mediated cell adhesion system in human cancers | Q35753235 | ||
| beta-1 Integrins mediate tumour cell adhesion to quiescent endothelial cells in vitro. | Q36141188 | ||
| Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase | Q36255812 | ||
| Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells | Q36322119 | ||
| SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma | Q36445884 | ||
| Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas. | Q37423273 | ||
| Cortactin associates with N-cadherin adhesions and mediates intercellular adhesion strengthening in fibroblasts | Q38336308 | ||
| Syk tyrosine kinase is linked to cell motility and progression in squamous cell carcinomas of the head and neck | Q40093746 | ||
| Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression | Q40351474 | ||
| The non-receptor-associated tyrosine kinase Syk is a regulator of metastatic behavior in human melanoma cells. | Q40410124 | ||
| EphA2 induction of fibronectin creates a permissive microenvironment for malignant cells. | Q40501139 | ||
| Progressive loss of Syk and abnormal proliferation in breast cancer cells | Q40502712 | ||
| Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase | Q40723397 | ||
| Beta1 integrin promotes but is not essential for metastasis of ras-myc transformed fibroblasts. | Q40935824 | ||
| Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling | Q40994288 | ||
| Rescue of the mutant phenotype by reexpression of full-length vinculin in null F9 cells; effects on cell locomotion by domain deleted vinculin | Q41044503 | ||
| Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. | Q41107962 | ||
| Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. | Q41326678 | ||
| Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. | Q41428182 | ||
| Transformation of human breast epithelial cells by c-Ha-ras oncogene | Q41701431 | ||
| Vinculin and alpha-catenin: shared and unique functions in adherens junctions | Q42686489 | ||
| Hypermethylation leads to silencing of the SYK gene in human breast cancer. | Q43675322 | ||
| Syk is required for integrin signaling in neutrophils | Q43968751 | ||
| Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. | Q44074366 | ||
| Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer | Q44542378 | ||
| Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness | Q45083949 | ||
| Expression and signaling activity of Wnt-5a/discoidin domain receptor-1 and Syk plays distinct but decisive roles in breast cancer patient survival. | Q45218090 | ||
| Clinical significance of nuclear expression of spleen tyrosine kinase (Syk) in gastric cancer | Q46579808 | ||
| Anti-β1Integrin IgG Inhibits Pulmonary Macrometastasis and the Size of Micrometastases from a Murine Mammary Carcinoma | Q47383406 | ||
| Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. | Q52537297 | ||
| Tyrosine phosphorylation of cortactin associated with Syk accompanies thromboxane analogue-induced platelet shape change. | Q54045583 | ||
| The Vav binding site of the non-receptor tyrosine kinase Syk at Tyr 348 is critical for beta2 integrin (CD11/CD18)-mediated neutrophil migration | Q58325788 | ||
| Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3 | Q72808954 | ||
| Signaling by adhesion in human neutrophils: activation of the p72syk tyrosine kinase and formation of protein complexes containing p72syk and Src family kinases in neutrophils spreading over fibrinogen | Q73064447 | ||
| Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain | Q73201940 | ||
| Attachment characteristics and involvement of integrins in adhesion of breast cancer cell lines to extracellular bone matrix components | Q74028892 | ||
| Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer | Q78555013 | ||
| Expression of Syk in invasive breast cancer: correlation to proliferation and invasiveness | Q79531918 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | breast cancer | Q128581 |
| cell adhesion | Q187640 | ||
| P304 | page(s) | 634-644 | |
| P577 | publication date | 2009-05-12 | |
| P1433 | published in | Molecular Cancer Research | Q2751014 |
| P1476 | title | Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells | |
| P478 | volume | 7 |
| Q30496002 | A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk |
| Q38827214 | Adherens Junction and E-Cadherin complex regulation by epithelial polarity. |
| Q28542829 | Adverse drug reaction prediction using scores produced by large-scale drug-protein target docking on high-performance computing machines |
| Q37205238 | Alternative splicing of spleen tyrosine kinase differentially regulates colorectal cancer progression |
| Q41921772 | Bioinformatics analysis of gene expression data for the identification of critical genes in breast invasive carcinoma |
| Q36659343 | CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma. |
| Q34625171 | Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer. |
| Q47141306 | Cortactin in cancer cell migration and invasion |
| Q38008316 | Cortactin in cell migration and cancer at a glance |
| Q34891306 | Cortactin: a multifunctional regulator of cellular invasiveness |
| Q37308097 | DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study |
| Q38471666 | Downregulation of spleen tyrosine kinase in hepatocellular carcinoma by promoter CpG island hypermethylation and its potential role in carcinogenesis |
| Q64280782 | Expression of Syk and MAP4 proteins in ovarian cancer |
| Q37646934 | Expression of variant isoforms of the tyrosine kinase SYK determines the prognosis of hepatocellular carcinoma. |
| Q30655964 | Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope |
| Q33609440 | In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers |
| Q52593090 | Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway. |
| Q47805346 | Lifetime exposure to ambient air pollution and methylation of tumor suppressor genes in breast tumors |
| Q54613082 | Lysophosphatidic acid (LPA) stimulates mouse mammary epithelial cell growth. |
| Q29994746 | Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves. |
| Q39557228 | Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors |
| Q37025183 | Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. |
| Q34972279 | Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. |
| Q35927161 | PPARgamma inhibits hepatocellular carcinoma metastases in vitro and in mice. |
| Q55345256 | Prognostic value of spleen tyrosine kinase in human solid tumors. |
| Q33783165 | Protein arginine methyltransferase 6 regulates multiple aspects of gene expression |
| Q39586702 | Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells |
| Q36312079 | Reconstruction and signal propagation analysis of the Syk signaling network in breast cancer cells. |
| Q36111557 | Regulation of adherens junction dynamics by phosphorylation switches. |
| Q34404016 | SYK allelic loss and the role of Syk-regulated genes in breast cancer survival. |
| Q35889476 | Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates. |
| Q38296865 | Spleen Tyrosine Kinase Modulates Fibrous Airway Obliteration and Associated Lymphoid Neogenesis After Transplantation |
| Q36760430 | Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit |
| Q34297938 | Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. |
| Q44962679 | Syk is low-expressed in non-small-cell lung cancer and inversely correlates with patient's survival |
| Q37462704 | Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion |
| Q35174128 | Targeting a cell state common to triple-negative breast cancers |
| Q91816605 | The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex |
| Q24294260 | The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2 |
| Q33510688 | Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo |
| Q27667961 | Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav |
| Q91017114 | Wnt5a induces ROR1 to recruit cortactin to promote breast-cancer migration and metastasis |
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