Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel

scientific article

Working model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.SBI.2011.01.001
P932PMC publication ID3070781
P698PubMed publication ID21296569
P5875ResearchGate publication ID49812889

P2093author name stringCarlos G Vanoye
Charles R Sanders
Wade D Van Horn
P2860cites workMiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmiaQ22009462
Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndromeQ22010246
A constitutively open potassium channel formed by KCNQ1 and KCNE3Q22011154
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunitsQ24301528
The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interactionQ24305236
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channelQ24318271
Mutations in the hminK gene cause long QT syndrome and suppress IKs functionQ24323571
Intracellular domains interactions and gated motions of I(KS) potassium channel subunitsQ24337820
KCNQ1 gain-of-function mutation in familial atrial fibrillationQ24338486
Structural insight into KCNQ (Kv7) channel assembly and channelopathyQ24619681
KCNE4 is an inhibitory subunit to the KCNQ1 channelQ24642042
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environmentQ27649044
Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channelQ27649693
Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel † ‡Q27651069
Crystal structure of a trimeric form of the KV7.1 (KCNQ1) A-domain tail coiled-coil reveals structural plasticity and context dependent changes in a putative coiled-coil trimerization motifQ27657087
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptorQ27658372
A Gating Charge Transfer Center in Voltage SensorsQ27660396
A common polymorphism associated with antibiotic-induced cardiac arrhythmiaQ28138550
Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2Q28145423
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformationsQ28188949
MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysisQ28201439
A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysisQ28213064
A single transmembrane site in the KCNE-encoded proteins controls the specificity of KvLQT1 channel gatingQ28216718
Preparation, functional characterization, and NMR studies of human KCNE1, a voltage-gated potassium channel accessory subunit associated with deafness and long QT syndromeQ28250352
IsK and KvLQT1: mutation in either of the two subunits of the slow component of the delayed rectifier potassium channel can cause Jervell and Lange-Nielsen syndromeQ28251067
Crystal structure of a mammalian voltage-dependent Shaker family K+ channelQ28260421
The conduction pore of a cardiac potassium channelQ28262167
Cloning of a membrane protein that induces a slow voltage-gated potassium currentQ28292630
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium currentQ28295470
Long QT syndrome-associated mutations in KCNQ1 and KCNE1 subunits disrupt normal endosomal recycling of IKs channelsQ28300861
Stoichiometry of the KCNQ1 - KCNE1 ion channel complex.Q28583726
Modeling structurally variable regions in homologous proteins with rosetta.Q30341350
KCNE1-like gene is deleted in AMME contiguous gene syndrome: identification and characterization of the human and mouse homologs.Q30776596
Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kineticsQ33148043
The long QT syndrome: a prospective international studyQ33168684
S1 constrains S4 in the voltage sensor domain of Kv7.1 K+ channelsQ33327357
KCNE1 constrains the voltage sensor of Kv7.1 K+ channelsQ33327366
Functional interactions between KCNE1 C-terminus and the KCNQ1 channelQ33425857
Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.Q33814293
A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs).Q33857759
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activationQ33922794
Identification of a protein-protein interaction between KCNE1 and the activation gate machinery of KCNQ1Q33922814
KCNE1 remodels the voltage sensor of Kv7.1 to modulate channel functionQ34388706
Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).Q34392041
KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.Q34452725
The KCNQ1 potassium channel: from gene to physiological functionQ34467640
The single nucleotide polymorphisms of I(Ks) potassium channel genes and their association with atrial fibrillation in a Chinese populationQ34570997
Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channelsQ34624463
KCNE regulation of KvLQT1 channels: structure-function correlatesQ34691356
Potassium channel subunits encoded by the KCNE gene family: physiology and pathophysiology of the MinK-related peptides (MiRPs).Q35679326
Ion channels: function unravelled by dysfunctionQ35934207
KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channelsQ36325866
Single-channel properties of IKs potassium channelsQ36436185
MinK subdomains that mediate modulation of and association with KvLQT1.Q36444720
Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexesQ36446328
KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domainsQ36667897
Kv7.1 (KCNQ1) properties and channelopathies.Q37049827
Sensing voltage across lipid membranesQ37069037
Location of KCNE1 relative to KCNQ1 in the I(KS) potassium channel by disulfide cross-linking of substituted cysteinesQ37070508
Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complexQ37412583
Delayed rectifier K(+) currents and cardiac repolarization.Q37580457
Ancillary subunits associated with voltage-dependent K+ channelsQ37731213
KCNE1 binds to the KCNQ1 pore to regulate potassium channel activityQ40543524
KCNE3 truncation mutants reveal a bipartite modulation of KCNQ1 K+ channelsQ41882406
Structural models for the KCNQ1 voltage-gated potassium channelQ42001843
Closing in on the resting state of the Shaker K(+) channel.Q42633636
Voltage sensor of Kv1.2: structural basis of electromechanical couplingQ46588794
Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle.Q46675989
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channelsQ48745779
The S4-S5 linker directly couples voltage sensor movement to the activation gate in the human ether-a'-go-go-related gene (hERG) K+ channel.Q50651862
De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero.Q50658517
Modulation of KCNQ1 current by atrial fibrillation-associated KCNE4 (145E/D) gene polymorphism.Q51799237
Charybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel ComplexQ58482877
MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channelQ77677778
P433issue2
P304page(s)283-291
P577publication date2011-02-04
P1433published inCurrent Opinion in Structural BiologyQ15758416
P1476titleWorking model for the structural basis for KCNE1 modulation of the KCNQ1 potassium channel
P478volume21

Reverse relations

cites work (P2860)
Q42372905Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells?
Q34566675Capturing distinct KCNQ2 channel resting states by metal ion bridges in the voltage-sensor domain
Q38126397Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking
Q36628028Dysfunctional potassium channel subunit interaction as a novel mechanism of long QT syndrome
Q64244254Folding and Misfolding of Human Membrane Proteins in Health and Disease: From Single Molecules to Cellular Proteostasis
Q34499486Fundamental role for the KCNE4 ancillary subunit in Kv7.4 regulation of arterial tone.
Q84785186Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers
Q36647350Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease
Q27027928KCNQ1 channel modulation by KCNE proteins via the voltage-sensing domain
Q38696328Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.
Q35893721Regulation of Voltage-Activated K(+) Channel Gating by Transmembrane β Subunits
Q35621580Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins
Q53042866Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
Q37245582Structural basis for KCNE3 modulation of potassium recycling in epithelia
Q39477676Unnatural amino acid photo-crosslinking of the IKs channel complex demonstrates a KCNE1:KCNQ1 stoichiometry of up to 4:4.
Q38690407Voltage-Dependent Gating: Novel Insights from KCNQ1 Channels

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