Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario

scientific article

Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1289/EHP.00108S2317
P932PMC publication ID1637762
P698PubMed publication ID10807561
P5875ResearchGate publication ID12509383

P2093author name stringEvans M
Boyes WK
Bushnell PJ
Crofton KM
Simmons JE
P2860cites workAcute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans.Q33583911
Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessmentQ33916719
Statistical analysis of Fisher et al. PBPK model of trichloroethylene kineticsQ35134362
Rat and human sensory evoked potentials and the predictability of human neurotoxicity from rat dataQ36715766
The ototoxicity of trichloroethylene: extrapolation and relevance of high-concentration, short-duration animal exposure dataQ36878463
CNS depressant effects of volatile organic solventsQ37181585
A critical review of time-weighted average as an index of exposure and dose, and of its key elementsQ39862021
Impact of occupational hearing loss on the lives of workersQ40956350
Distribution of cardiac output during diurnal changes of activity in ratsQ41171768
Partition coefficients of some aromatic hydrocarbons and ketones in water, blood and oilQ41431665
Physiological pharmacokinetic modeling of inhaled trichloroethylene in ratsQ45184528
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissuesQ47173676
Physiologically-based pharmacokinetic model for trichloroethylene considering enterohepatic recirculation of major metabolitesQ47843571
Effects of medial prefrontal or anterior cingulate cortex lesions on responding for cocaine under fixed-ratio and second-order schedules of reinforcement in rats.Q48560215
Solvent-induced ototoxicity in rats: an atypical selective mid-frequency hearing deficit.Q50523199
Mid-frequency hearing loss in rats following inhalation exposure to trichloroethylene: evidence from reflex modification audiometry.Q50527387
Mid-frequency hearing loss and reduction of acoustic startle responding in rats following trichloroethylene exposure.Q50527391
Sensory-evoked potentials in rats chronically exposed to trichloroethylene: predominant auditory dysfunction.Q50546195
A human physiologically based pharmacokinetic model for trichloroethylene and its metabolites, trichloroacetic acid and free trichloroethanol.Q50852848
Physiologically based pharmacokinetic modeling of inhaled trichloroethylene and its oxidative metabolites in B6C3F1 mice.Q51476962
Concentration-time relationships for the effects of inhaled trichloroethylene on signal detection behavior in rats.Q51547577
Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.Q51738673
Physiologically based pharmacokinetic modeling of the pregnant rat: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid.Q51751604
Quantitative evaluation of the metabolic interactions between trichloroethylene and 1,1-dichloroethylene in vivo using gas uptake methods.Q51789218
A dosimetric analysis of behavioral effects of acute toluene exposure in rats and humans.Q52185195
Effects of single exposure to toluene on operant behavior and brain toluene levels in rats.Q52277712
A comparison of the acute neuroactive effects of dichloromethane, 1,3-dichloropropane, and 1,2-dichlorobenzene on rat flash evoked potentials (FEPs).Q52552267
A new method for determining allowable daily intakes.Q52687390
A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans.Q52695093
Adjusting Exposure Limits for Long and Short Exposure Periods Using A Physiological Pharmacokinetic ModelQ57383628
Reference dose (RfD): description and use in health risk assessmentsQ68026014
Physiologically based pharmacokinetic estimated metabolic constants and hepatotoxicity of carbon tetrachloride after methanol pretreatment in ratsQ71718095
Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in ratsQ72171241
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
neurotoxicityQ3338704
hydrocarbonQ43648
impact of the environmentQ26897695
P1104number of pages6
P304page(s)317-322
P577publication date2000-05-01
P1433published inEnvironmental Health PerspectivesQ1345904
P1476titleNeurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario
P478volume108 Suppl 2

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cites work (P2860)
Q46981486An example of model structure differences using sensitivity analyses in physiologically based pharmacokinetic models of trichloroethylene in humans
Q46786767Application of PBPK modeling in support of the derivation of toxicity reference values for 1,1,1-trichloroethane.
Q37201545Approaches for applications of physiologically based pharmacokinetic models in risk assessment
Q58402056Assessing the impact of the duration and intensity of inhalation exposure on the magnitude of the variability of internal dose metrics in children and adults
Q51407706Behavioral components of tolerance to repeated inhalation of trichloroethylene (TCE) in rats.
Q43855521Characterizing tolerance to trichloroethylene (TCE): effects of repeated inhalation of TCE on performance of a signal detection task in rats
Q42730136Chronic exposure to trichloroethylene affects neuronal plasticity in rat hippocampal slices
Q43239567Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments
Q46603013Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model
Q33916719Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment
Q35039295Key scientific issues in the health risk assessment of trichloroethylene
Q46601305Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose
Q33916692Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene
Q43336435Recycled water: potential health risks from volatile organic compounds and use of 1,4-dichlorobenzene as treatment performance indicator.
Q35802386The Acute Exposure Guideline Level (AEGL) program: applications of physiologically based pharmacokinetic modeling
Q46952375The role of physical activity and feeding schedule on the kinetics of inhaled and oral toluene in rats
Q24671489Trichloroethylene health risks--state of the science

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