Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments

scientific article published in December 2009

Development of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/08958370903005751
P698PubMed publication ID19922404

P50authorSean DowdQ57402478
P2093author name stringRandy Harrison
Jane Ellen Simmons
Hisham A El-Masri
Rex A Pegram
Marina Evans
Sisouphanh J Yavanhxay
P2860cites workNeurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenarioQ30503509
A physiologically based simulation approach for determining metabolic constants from gas uptake dataQ36481076
Pitfalls and related improvements of in vivo gas uptake pharmacokinetic experimental systemsQ40403640
The application of physiologically based pharmacokinetic modeling in human health risk assessment of hazardous substancesQ40419586
Application of physiologically based pharmacokinetic modelling to combination toxicologyQ41445873
Physiological parameter values for physiologically based pharmacokinetic modelsQ41556435
Identification of urinary metabolites of the nephrotoxic hydrocarbon 2,2,4-trimethylpentane in male ratsQ42228741
2,2,4-Trimethylpentane-induced nephrotoxicity. I. Metabolic disposition of TMP in male and female Fischer 344 ratsQ44053383
A physiologically based pharmacokinetic model for trichloroethylene in the male long-evans rat.Q44128138
Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual functionQ44547634
Momentary brain concentration of trichloroethylene predicts the effects on rat visual functionQ46564764
Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal doseQ46601305
Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic modelQ46603013
Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissuesQ47173676
Acute toluene exposure and rat visual function in proportion to momentary brain concentration.Q48109156
A dosimetric analysis of the acute behavioral effects of inhaled toluene in rats.Q48146851
Acute inhalation toxicology of volatile hydrocarbons.Q52722050
Sensitivity Analysis and the Design of Gas Uptake Inhalation StudiesQ57383478
P433issue14
P921main subjectpharmacokineticsQ323936
P304page(s)1176-1185
P577publication date2009-12-01
P1433published inInhalation ToxicologyQ1663495
P1476titleDevelopment of an inhalation physiologically based pharmacokinetic (PBPK) model for 2,2, 4-trimethylpentane (TMP) in male Long-Evans rats using gas uptake experiments
P478volume21

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cites work (P2860)
Q51479956Computational estimation of errors generated by lumping of physiologically-based pharmacokinetic (PBPK) interaction models of inhaled complex chemical mixtures.
Q40230063Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure.

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