Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis

scientific article

Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2011-12-398149
P932PMC publication ID3367878
P698PubMed publication ID22493296

P50authorDouglas CinesQ16204220
John P AtkinsonQ88032294
Vladimir R MuzykantovQ89339994
Mortimer PonczQ124218035
Ronald CarnemollaQ125229991
Maria KowalskaQ67196707
P2093author name stringBi-Sen Ding
Charles T Esmon
Michael Neyman
Samira Tliba
Dirk Spitzer
Sergei Zaitsev
Aaron Stonestrom
P2860cites workActivated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotectiveQ24293646
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Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3Q28587775
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Human complement receptor type 1-directed loading of tissue plasminogen activator on circulating erythrocytes for prophylactic fibrinolysisQ30444430
Analysis of the spatial and temporal characteristics of platelet-delivered factor VIII-based clotsQ30483038
Anchoring fusion thrombomodulin to the endothelial lumen protects against injury-induced lung thrombosis and inflammationQ30489456
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysisQ33714889
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formationQ33944248
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trialQ79292898
Amplified anticoagulant activity of tissue factor-targeted thrombomodulin: in-vivo validation of a tissue factor-neutralizing antibody fused to soluble thrombomodulinQ80213978
Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa BQ81333617
Do-all receptor takes on coagulation, inflammationQ81718324
Cooperative action between band 3 and glycophorin A in human erythrocytes: immobilization of band 3 induced by antibodies to glycophorin A.Q34115376
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Inflammation and thrombosisQ35181574
Thrombomodulin.Q35181628
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Red blood cell glycophorins.Q35362789
Thromboerythrocytes. In vitro studies of a potential autologous, semi-artificial alternative to platelet transfusionsQ35597837
Activated protein C and ischemic strokeQ35760626
Endothelial targeting of a recombinant construct fusing a PECAM-1 single-chain variable antibody fragment (scFv) with prourokinase facilitates prophylactic thrombolysis in the pulmonary vasculatureQ35848131
Prophylactic thrombolysis by thrombin-activated latent prourokinase targeted to PECAM-1 in the pulmonary vasculatureQ36445835
Inflammation and the activated protein C anticoagulant pathwayQ36467895
Reduced red blood cell destruction by antibody fragmentsQ36701838
Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cellsQ36851476
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Thrombomodulin and its role in inflammation.Q37909178
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in cultureQ41946791
Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic miceQ43582783
Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell deathQ45124371
Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapyQ45862908
Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatmentQ45864060
Intravascular coagulation activation in a murine model of thrombomodulin deficiency: effects of lesion size, age, and hypoxia on fibrin deposition.Q47275663
Crosstalk between inflammation and thrombosisQ47814059
Capillary endothelial thrombomodulin expression and fibrin deposition in rats with continuous and bolus lipopolysaccharide administration.Q51836227
Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in plateletsQ53934182
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin.Q54483487
Early loss of thrombomodulin expression impairs vein graft thromboresistance: implications for vein graft failureQ64379178
A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in miceQ69820009
Modulation of human endothelial thrombomodulin by neutrophils and their release productsQ72991619
Prophylactic fibrinolysis through selective dissolution of nascent clots by tPA-carrying erythrocytesQ73621576
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complementQ75270684
Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparinQ75424151
ThrombinQ77054123
Association between decreased pulmonary endothelial cell thrombomodulin and local fibrin deposition in pneumoniaQ77325357
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)4779-4785
P577publication date2012-04-04
P1433published inBloodQ885070
P1476titleTargeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis
P478volume119

Reverse relations

cites work (P2860)
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Q49351130Nanoparticle Properties Modulate Their Attachment and Effect on Carrier Red Blood Cells
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