| review article | Q7318358 |
| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1047279730 |
| P356 | DOI | 10.1023/B:THRO.0000011370.80989.7B |
| P698 | PubMed publication ID | 14739624 |
| P2093 | author name string | Erica De Candia | |
| Raimondo De Cristofaro | |||
| P2860 | cites work | Role of thrombin anion-binding exosite-I in the formation of thrombin-serpin complexes | Q77545159 |
| Three-dimensional modeling of thrombin-fibrinogen interaction | Q77785700 | ||
| Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain | Q24304907 | ||
| Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha | Q24307780 | ||
| Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation | Q24337851 | ||
| Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin | Q24563384 | ||
| Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor | Q24598030 | ||
| Unexpected crucial role of residue 225 in serine proteases | Q27617423 | ||
| Solution structure of the smallest cofactor-active fragment of thrombomodulin | Q27621626 | ||
| Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex | Q27622194 | ||
| Interaction of the factor XIII activation peptide with alpha -thrombin. Crystal structure of its enzyme-substrate analog complex | Q27626679 | ||
| Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions | Q27634192 | ||
| Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activation | Q27639267 | ||
| The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form | Q27640906 | ||
| Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation | Q27641665 | ||
| The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships | Q27642041 | ||
| Refined structure of the hirudin-thrombin complex | Q27653704 | ||
| The structure of a complex of recombinant hirudin and human alpha-thrombin | Q27684792 | ||
| Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin | Q27730738 | ||
| Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101 | Q72050302 | ||
| The Na+ Binding Site of Thrombin | Q72054938 | ||
| Effects of protons on the thrombin-fibrinogen interaction | Q72252430 | ||
| Mapping of the thrombin des-ETW conformation by using site-directed mutants of hirudin. Evidence for the induction of nonlocal modifications by mutagenesis | Q72326679 | ||
| Conformational transitions linked to active site ligation in human thrombin: effect on the interaction with fibrinogen and the cleavable platelet receptor | Q72472585 | ||
| Identification of basic amino acid residues in thrombin essential for heparin-catalyzed inactivation by antithrombin III | Q72724984 | ||
| Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components | Q72726469 | ||
| The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity | Q72992335 | ||
| Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage | Q73004111 | ||
| Structural and functional diversity in the leucine-rich repeat family of proteins | Q73066306 | ||
| Thrombin interaction with platelet GpIB: role of the heparin binding domain | Q73305324 | ||
| The dual role of thrombin's anion-binding exosite-I in the recognition and cleavage of the protease-activated receptor 1 | Q73307391 | ||
| The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III | Q73413882 | ||
| Protease-activated G protein-coupled receptors on human platelets and endothelial cells | Q73447373 | ||
| Comparative analysis of haemostatic proteinases: structural aspects of thrombin, factor Xa, factor IXa and protein C | Q73447526 | ||
| Characterization of proexosite I on prothrombin | Q73626476 | ||
| Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation | Q73626480 | ||
| Electrostatic steering and ionic tethering in the formation of thrombin-hirudin complexes: the role of the thrombin anion-binding exosite-I | Q73762746 | ||
| Elements of the primary structure of thrombomodulin required for efficient thrombin-activable fibrinolysis inhibitor activation | Q73762875 | ||
| Thrombomodulin increases the rate of thrombin inhibition by BPTI | Q74024123 | ||
| Hemostatic risk factors for atherothrombotic disease: an epidemiologic view | Q74314964 | ||
| Molecular mapping of thrombin-receptor interactions | Q74527941 | ||
| Thrombin-mediated proteolysis of factor V resulting in gradual B-domain release and exposure of the factor Xa-binding site | Q74578461 | ||
| Allosteric modulation of BPTI interaction with human alpha- and zeta-thrombin | Q74634783 | ||
| Identification of critical residues on thrombin mediating its interaction with fibrin | Q77447782 | ||
| Crystallographic structure of human gamma-thrombin | Q27730886 | ||
| Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes | Q27731248 | ||
| Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin | Q27732031 | ||
| PAR3 is a cofactor for PAR4 activation by thrombin | Q28141872 | ||
| Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway | Q28256355 | ||
| Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4 | Q28577425 | ||
| Molecular defects of platelets in Bernard-Soulier syndrome | Q33476498 | ||
| Thrombin interaction with platelet GpIb: structural mapping and effects on platelet activation (review). | Q33543257 | ||
| Thrombin modulates and reverses neuroblastoma neurite outgrowth | Q33573970 | ||
| Identification of residues linked to the slow-->fast transition of thrombin | Q33763127 | ||
| The glycoprotein Ib-IX-V complex in platelet adhesion and signaling | Q33800060 | ||
| Regulation of blood coagulation | Q33857528 | ||
| Theory of allosteric effects in serine proteases. | Q34016899 | ||
| Role of thrombin signalling in platelets in haemostasis and thrombosis | Q34090283 | ||
| Predominant contribution of surface approximation to the mechanism of heparin acceleration of the antithrombin-thrombin reaction. Elucidation from salt concentration effects. | Q34092914 | ||
| Factor XIII: structure, activation, and interactions with fibrinogen and fibrin. | Q34311804 | ||
| The interaction of thrombin with fibrinogen. A structural basis for its specificity | Q34416186 | ||
| Direct thrombin inhibitors in acute coronary syndromes: present and future | Q34543601 | ||
| Molecular mapping of the heparin-binding exosite of thrombin | Q35478768 | ||
| High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domains | Q35569261 | ||
| Amelioration of collagen-induced arthritis by thrombin inhibition | Q36013702 | ||
| An Arg-Gly-Asp sequence within thrombin promotes endothelial cell adhesion | Q36529134 | ||
| Oligonucleotide inhibitors of human thrombin that bind distinct epitopes | Q36890950 | ||
| Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin | Q37565691 | ||
| Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin | Q37582778 | ||
| Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets | Q38306581 | ||
| Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin | Q38325903 | ||
| The oligosaccharide of human thrombin: investigations of functional significance | Q38354182 | ||
| Tryptophan 60-D in the B-insertion loop of thrombin modulates the thrombin-antithrombin reaction | Q38361731 | ||
| The clot thickens: clues provided by thrombin structure. | Q40605453 | ||
| Molecular and functional characterization of a natural homozygous Arg67His mutation in the prothrombin gene of a patient with a severe procoagulant defect contrasting with a mild hemorrhagic phenotype | Q40714431 | ||
| Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains | Q40932840 | ||
| Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation | Q40970894 | ||
| The thrombin receptor in the nervous system. | Q41112666 | ||
| Mutagenesis of thrombin selectively modulates inhibition by serpins heparin cofactor II and antithrombin III. Interaction with the anion-binding exosite determines heparin cofactor II specificity | Q41573255 | ||
| Molecular mechanisms of thrombin function | Q41642235 | ||
| Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex | Q41765295 | ||
| Allosteric modulation of the activity of thrombin | Q41878350 | ||
| Binding of human alpha-thrombin to platelet GpIb: energetics and functional effects. | Q41918902 | ||
| Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII. | Q41934357 | ||
| Evidence for common structural changes in thrombin induced by active-site or exosite binding | Q41971795 | ||
| Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues. | Q42614908 | ||
| The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin | Q42619428 | ||
| The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-thrombin | Q42796533 | ||
| An extensive interaction interface between thrombin and factor V is required for factor V activation | Q43581648 | ||
| Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib. | Q43782195 | ||
| Helix D elongation and allosteric activation of antithrombin. | Q43821727 | ||
| Allosteric effects potentiating the release of the second fibrinopeptide A from fibrinogen by thrombin | Q43916129 | ||
| Linkage between proton binding and amidase activity in human alpha-thrombin: effect of ions and temperature | Q45037492 | ||
| Binding of the bovine basic pancreatic trypsin inhibitor (Kunitz) to human alpha-, beta- and gamma-thrombin; a kinetic and thermodynamic study | Q45218467 | ||
| Thrombin is a Na(+)-activated enzyme | Q45261449 | ||
| Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor | Q45711172 | ||
| Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates | Q46807273 | ||
| Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparin | Q47262509 | ||
| Effect of high- and low-molecular-weight heparins on thrombin-thrombomodulin interaction and protein C activation | Q47280861 | ||
| Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa. | Q50335789 | ||
| The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen. | Q52475064 | ||
| Heparin cofactor II is regulated allosterically and not primarily by template effects. Studies with mutant thrombins and glycosaminoglycans. | Q52510803 | ||
| Effect of protons on the amidase activity of human alpha-thrombin. Analysis in terms of a general linkage scheme. | Q53732067 | ||
| Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor. | Q54199473 | ||
| Reconstitution of catalytically competent human .zeta.-thrombin by combination of .zeta.-thrombin residues A1-36 and B1-148 and an Escherichia coli expressed polypeptide corresponding to .zeta.-thrombin residues B149-259 | Q54687426 | ||
| Late-fibrin(ogen) fragment E modulates human alpha-thrombin specificity | Q58425886 | ||
| Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. | Q60265904 | ||
| Linkage between proton binding and amidase activity in human gamma-thrombin | Q67485903 | ||
| Mechanistic studies on thrombin catalysis | Q68000625 | ||
| Characterization of the kinetic pathway for fibrin promotion of alpha-thrombin-catalyzed activation of plasma factor XIII | Q68186648 | ||
| The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity | Q68254346 | ||
| Enzymatic properties of proteolytic derivatives of human alpha-thrombin | Q68389225 | ||
| Human alpha- to zeta-thrombin cleavage occurs with neutrophil cathepsin G or chymotrypsin while fibrinogen clotting activity is retained | Q68817200 | ||
| Proteolytic derivatives of thrombin | Q68990174 | ||
| Human neutrophil elastase alters human alpha-thrombin function: limited proteolysis near the gamma-cleavage site results in decreased fibrinogen clotting and platelet-stimulatory activity | Q70326803 | ||
| The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors | Q70472177 | ||
| Contributions of glycoprotein Ib and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca2+] induced by alpha-thrombin | Q70862491 | ||
| Differentiation of the two forms of GPIb functioning as receptors for alpha-thrombin and von Willebrand factor: Ca2+ responses of protease-treated human platelets activated with alpha-thrombin and the tethered ligand peptide | Q70862495 | ||
| The role of the insertion loop around tryptophan 148 in tthe activity of thrombin | Q71010225 | ||
| Effect of sodium on the energetics of thrombin-thrombomodulin interaction and its relevance for protein C hydrolysis | Q71039709 | ||
| Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII | Q71143329 | ||
| Evidence that human alpha-thrombin is a monovalent cation-activated enzyme | Q71257633 | ||
| Monocyte chemotaxis: stimulation by specific exosite region in thrombin | Q71695951 | ||
| Identification of thrombin residues that modulate its interactions with antithrombin III and alpha 1-antitrypsin | Q71715354 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 151-163 | |
| P577 | publication date | 2003-06-01 | |
| P1433 | published in | Journal of Thrombosis and Thrombolysis | Q15766541 |
| P1476 | title | Thrombin domains: structure, function and interaction with platelet receptors | |
| P478 | volume | 15 |
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