Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.

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Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M004164200
P698PubMed publication ID11024046

P50authorJ. Evan SadlerQ42645712
P2093author name stringVindigni A
Li CQ
Wardell MR
P2860cites workProtease-activated receptor 3 is a second thrombin receptor in humansQ24310957
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin bindingQ24314966
Cloning and characterization of human protease-activated receptor 4Q24322941
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
Peptide exosite inhibitors of factor VIIa as anticoagulantsQ27622190
The molecular environment of the Na+ binding site of thrombinQ27736084
A dual thrombin receptor system for platelet activationQ28280578
Evidence for allosteric linkage between exosites 1 and 2 of thrombinQ73770372
Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activationQ74088680
Platelet responses to compound interactions with thrombinQ78021240
Identification of the disulphide bonds in human platelet glycocalicinQ34131135
An allosteric switch controls the procoagulant and anticoagulant activities of thrombinQ34172057
Structure of the Ca2+-free GLA domain sheds light on membrane binding of blood coagulation proteinsQ34304306
Regulation of thrombin activity by antithrombin and heparinQ34321620
Structure and function of platelet membrane glycoproteins Ib and V. Effects of leukocyte elastase and other proteases on platelets response to von Willebrand factor and thrombinQ34562281
Interaction of coagulation factor Xa with human plateletsQ35053163
Molecular mapping of the heparin-binding exosite of thrombinQ35478768
High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domainsQ35569261
Platelet procoagulant activity: physiological significance and mechanisms of exposureQ36928487
Reduced thrombin binding and aggregation in Bernard-Soulier plateletsQ37052459
Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombinQ37565691
Tyrosine sulfation of the glycoprotein Ib-IX complex: identification of sulfated residues and effect on ligand bindingQ38302282
Platelet physiology and abnormalities of platelet function (first of two parts).Q39944486
A player of many parts: the spotlight falls on thrombin's structure.Q40893212
Effective electrostatic charge of coagulation factor X in solution and on phospholipid membranes: implications for activation mechanisms and structure-function relationships of the Gla domainQ41052593
Thrombin interaction with platelet membrane glycoprotein Ib.Q41112678
Molecular mechanisms of thrombin functionQ41642235
Thrombin Receptors of Human Platelets: Thrombin Binding and Antithrombin Properties of Glycoprotein IQ41724872
Binding of human alpha-thrombin to platelet GpIb: energetics and functional effects.Q41918902
The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1Q44595454
Thrombin is a Na(+)-activated enzymeQ45261449
Expression of platelet glycoprotein (GP) V in heterologous cells and evidence for its association with GP Ib alpha in forming a GP Ib-IX-V complex on the cell surface.Q45962782
Thrombin-induced platelet activation is inhibited by high- and low-molecular-weight heparinQ47262509
Energetics of thrombin-thrombomodulin interaction.Q52262163
Role of the thrombin receptor in development and evidence for a second receptor.Q52519548
Quantitative evaluation of the contribution of ionic interactions to the formation of the thrombin-hirudin complex.Q52523504
Interaction of von Willebrand Factor Domain A1 with Platelet Glycoprotein Ibα-(1–289)Q60265920
Effect of heparin on the interaction between thrombin and hirudinQ69467938
Thrombin interactions with platelet membrane proteinsQ70173281
Chemical compensation in macromolecular bridge-binding to thrombinQ70622059
Release of fibrinopeptides by the slow and fast forms of thrombinQ71010220
Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartateQ71869446
The Na+ Binding Site of ThrombinQ72054938
A simple activity assay for thrombin and hirudinQ72871873
Preparation and application of a photoreactive thrombin analog: binding to human plateletsQ72908042
The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin IIIQ73413882
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)6161-6168
P577publication date2000-10-09
P1433published inJournal of Biological ChemistryQ867727
P1476titlePlatelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.
P478volume276

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cites work (P2860)
Q31130787A novel class of small functional peptides that bind and inhibit human alpha-thrombin isolated by mRNA display
Q36788507Allosterism-based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα-binding and heparin-binding site of thrombin.
Q77296407Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II
Q27667770Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I
Q33480624Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.
Q36053189Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function
Q78862527Establishing the inhibitory effects of bradykinin on thrombin
Q84509369Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes
Q36884329Exosites in the substrate specificity of blood coagulation reactions
Q35349699Fast photochemical oxidation of proteins for epitope mapping
Q44518940Fibrinogen gamma' chain binds thrombin exosite II.
Q27680808GpIbα Interacts Exclusively with Exosite II of Thrombin
Q61943901Inhibition of thrombin activity by prothrombin activation fragment 1.2
Q41934357Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.
Q34333809Platelet glycoproteins and their role in diseases
Q38530486Structural transitions during prothrombin activation: On the importance of fragment 2
Q42194253Studies on the basis for the properties of fibrin produced from fibrinogen-containing gamma' chains
Q34264585Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.
Q37426582Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.
Q28236023Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects
Q45063820Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively
Q34291931Thrombin domains: structure, function and interaction with platelet receptors
Q53061821Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib

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