Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I

scientific article

Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2011PNAS..108.8628Z
P356DOI10.1073/PNAS.1017042108
P3181OpenCitations bibliographic resource ID775293
P932PMC publication ID3102361
P698PubMed publication ID21555542
P5875ResearchGate publication ID51110742

P50authorKottayil I VarugheseQ87085902
P2093author name stringHua Jing
Reha Celikel
Zaverio M Ruggeri
Kevin L Moore
James R Roberts
G Loredana Mendolicchio
Alessandro Zarpellon
Richard A McClintock
P2860cites workStructures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domainQ24304907
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein IbalphaQ24307780
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin bindingQ24314966
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutationsQ24319306
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregationQ27641665
The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsQ27642041
Refined structure of the hirudin-thrombin complexQ27653704
Structure of the hirugen and hirulog 1 complexes of alpha-thrombinQ27655399
The structure of a complex of recombinant hirudin and human alpha-thrombinQ27684792
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamerQ27730933
Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegansQ28115054
The Biology and Enzymology of Protein Tyrosine O-SulfationQ28202302
In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.Q33323650
Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.Q33480624
Selection of single-stranded DNA molecules that bind and inhibit human thrombinQ34616171
Signaling and regulation of the platelet glycoprotein Ib-IX-V complexQ34616663
Platelet adhesion under flowQ34673739
The GPIbalpha-thrombin interaction: far from crystal clear.Q35628260
Adhesion mechanisms in platelet functionQ36856340
Oligonucleotide inhibitors of human thrombin that bind distinct epitopesQ36890950
Survey of the year 2006 commercial optical biosensor literatureQ37030018
Tyrosine sulfation of the glycoprotein Ib-IX complex: identification of sulfated residues and effect on ligand bindingQ38302282
HD1, a thrombin-directed aptamer, binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinaseQ38308474
Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinaseQ38360396
Platelet glycocalicin. Interaction with thrombin and role as thrombin receptor of the platelet surfaceQ41406687
Tyrosylprotein sulfotransferase-2 expression is required for sulfation of RNase 9 and Mfge8 in vivoQ41824473
Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.Q41934357
Long range communication between exosites 1 and 2 modulates thrombin functionQ42030991
Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.Q43782195
Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitorQ45711172
Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein IbQ53061821
The vascular biology of the glycoprotein Ib-IX-V complexQ59281509
Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.Q60265904
Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with plateletsQ67768931
Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombinQ67775135
The von Willebrand factor-binding domain of platelet membrane glycoprotein Ib. Characterization by monoclonal antibodies and partial amino acid sequence analysis of proteolytic fragmentsQ70010199
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alphaQ72272743
Thrombin interaction with platelet GpIB: role of the heparin binding domainQ73305324
The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin IIIQ73413882
Von Willebrand factorQ78961529
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)8628-33
P577publication date2011-05-24
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleBinding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I
P478volume108

Reverse relations

cites work (P2860)
Q5233062214-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
Q36053189Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function
Q35140258Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation
Q30650321Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis
Q27680808GpIbα Interacts Exclusively with Exosite II of Thrombin
Q57025284Humanized GPIbα-von Willebrand factor interaction in the mouse
Q39147112New Concepts and Mechanisms of Platelet Activation Signaling
Q36355586Platelet mimetic particles for targeting thrombi in flowing blood
Q37619118Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain
Q36547814Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
Q27681197Structural Basis of Regulation of von Willebrand Factor Binding to Glycoprotein Ib
Q34137856Structural and energetic determinants of tyrosylprotein sulfotransferase sulfation specificity
Q34264585Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.
Q33397768The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies
Q27006905Thrombin inhibition by the serpins
Q45245513Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.
Q34106824von Willebrand factor, Jedi knight of the bloodstream

Search more.