Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain

scientific article published on 15 April 2012

Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1021/BI2016519
P932PMC publication ID3943421
P698PubMed publication ID22439748

P2093author name stringMichael G Fried
Kristine S Alexander
David H Farrell
P2860cites workInteractions of human fibrinogens with factor XIII: roles of calcium and the gamma' peptideQ73829141
gammaA/gamma' fibrinogen inhibits thrombin-induced platelet aggregationQ79804224
Bivalent binding to gammaA/gamma'-fibrin engages both exosites of thrombin and protects it from inhibition by the antithrombin-heparin complexQ80137272
Crystal structure of thrombin in complex with fibrinogen gamma' peptideQ80235175
Imaging fibrin formation and platelet and endothelial cell activation in vivoQ83709183
The catch bond mechanism between von Willebrand factor and platelet surface receptors investigated by molecular dynamics simulationsQ84523995
Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite IQ27667770
Conformational analysis of gamma' peptide (410-427) interactions with thrombin anion binding exosite II.Q33246486
The effects of exosite occupancy on the substrate specificity of thrombinQ33488133
Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chainsQ34392346
ThrombinQ36800534
Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin.Q37426582
Recombinant human fibrinogen and sulfation of the gamma' chainQ41662631
Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptorsQ42054506
Fibrinogen gamma' chain binds thrombin exosite II.Q44518940
Fibrinogen gamma' chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathwayQ46970925
Evidence that both exosites on thrombin participate in its high affinity interaction with fibrinQ47967245
Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen.Q48386755
.gamma. and .gamma.' chains of human fibrinogen are produced by alternative mRNA processingQ48388090
Contribution of exosite occupancy by heparin to the regulation of coagulation proteases by antithrombin.Q55077829
Thrombin binding to the A alpha-, B beta-, and gamma-chains of fibrinogen and to their remnants contained in fragment EQ68506599
Identification and characterization of the thrombin binding sites on fibrinQ71514735
Human fibrinogen--structural variants and functional sitesQ72595215
The amino acid sequence in fibrin responsible for high affinity thrombin bindingQ73769028
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)3445-3450
P577publication date2012-04-15
P1433published inBiochemistryQ764876
P1476titleRole of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain
P478volume51

Reverse relations

cites work (P2860)
Q44001534Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ'.
Q38061449The role of protonation states in ligand-receptor recognition and binding

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