| scholarly article | Q13442814 |
| P50 | author | Maureane Hoffman | Q42882680 |
| P2093 | author name string | Bruce A Sullenger | |
| Shahid M Nimjee | |||
| Kristin M Bompiani | |||
| Sabah Oney | |||
| Zoya Volovyk | |||
| Steve B Long | |||
| P2860 | cites work | Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha | Q24307780 |
| Crystal structure of an RNA aptamer bound to thrombin | Q24652403 | ||
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| The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamer | Q27730933 | ||
| Role of antiplatelet therapy in cardiovascular disease I: Acute coronary syndromes | Q28171491 | ||
| Both the high affinity thrombin receptor (GPIb-IX-V) and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity | Q28202822 | ||
| Thrombin signalling and protease-activated receptors | Q29619601 | ||
| Generation of species cross-reactive aptamers using "toggle" SELEX. | Q30773712 | ||
| Aptamers: an emerging class of therapeutics | Q33211036 | ||
| A rapid method to isolate platelets from human blood by density gradient centrifugation | Q33359170 | ||
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| New anticoagulant therapy | Q36014671 | ||
| A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation | Q36212737 | ||
| A double-filter method for nitrocellulose-filter binding: application to protein-nucleic acid interactions | Q36356454 | ||
| Molecular assembly for high-performance bivalent nucleic acid inhibitor | Q36558122 | ||
| Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets | Q38306581 | ||
| Effect of oligodeoxynucleotide thrombin aptamer on thrombin inhibition by heparin cofactor II and antithrombin | Q38306930 | ||
| A SELEX primer | Q38363376 | ||
| Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib. | Q43782195 | ||
| RNA aptamer to thrombin binds anion-binding exosite-2 and alters protease inhibition by heparin-binding serpins | Q47344343 | ||
| Evidence that both exosites on thrombin participate in its high affinity interaction with fibrin | Q47967245 | ||
| Association of gammaA/gamma' fibrinogen levels and coronary artery disease. | Q50277146 | ||
| New anticoagulants | Q57243773 | ||
| An Ambiguous Structure of a DNA 15-mer Thrombin Complex | Q60163781 | ||
| Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. | Q60265904 | ||
| In vivo anticoagulant properties of a novel nucleotide-based thrombin inhibitor and demonstration of regional anticoagulation in extracorporeal circuits | Q70751713 | ||
| Evidence for allosteric linkage between exosites 1 and 2 of thrombin | Q73770372 | ||
| Exosites 1 and 2 are essential for protection of fibrin-bound thrombin from heparin-catalyzed inhibition by antithrombin and heparin cofactor II | Q74485125 | ||
| Antidote-mediated control of an anticoagulant aptamer in vivo | Q80903179 | ||
| Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer | Q81569457 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2105-2111 | |
| P577 | publication date | 2009-10-21 | |
| P1433 | published in | RNA | Q7277164 |
| P1476 | title | Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin | |
| P478 | volume | 15 |
| Q38327215 | A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. |
| Q49833933 | A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin |
| Q54758785 | Aptamer-guided caging for selective masking of protein domains. |
| Q38290290 | Aptamers as targeted therapeutics: current potential and challenges |
| Q34879171 | Array-based discovery of aptamer pairs |
| Q34456694 | Artificial specific binders directly recovered from chemically modified nucleic acid libraries |
| Q24652403 | Crystal structure of an RNA aptamer bound to thrombin |
| Q34604052 | Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site |
| Q38332550 | Highly efficient control of thrombin activity by multivalent nanoparticles |
| Q28816936 | Modulation of the Coagulation Cascade Using Aptamers |
| Q58700124 | Molecular Modeling Applied to Nucleic Acid-Based Molecule Development |
| Q54614934 | Molecular dynamics simulations of aptamer-binding reveal generalized allostery in thrombin. |
| Q34459376 | New Technologies Provide Quantum Changes in the Scale, Speed, and Success of SELEX Methods and Aptamer Characterization |
| Q34477404 | On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different |
| Q35921730 | Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. |
| Q93108461 | Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels |
| Q34052471 | Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation |
| Q38295867 | Regulation of fibrin-mediated tumor cell adhesion to the endothelium using anti-thrombin aptamer |
| Q37619118 | Role of electrostatic interactions in binding of thrombin to the fibrinogen γ' chain |
| Q47363650 | Specific Light-Up System for Protein and Metabolite Targets Triggered by Initiation Complex Formation. |
| Q36580126 | Targeting Two Coagulation Cascade Proteases with a Bivalent Aptamer Yields a Potent and Antidote-Controllable Anticoagulant |
| Q88207375 | Thrombin-induced platelet activation via PAR4: pivotal role for exosite II |
| Q38289988 | Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers. |
| Q37809781 | Translating Nucleic Acid Aptamers to Antithrombotic Drugs in Cardiovascular Medicine |
| Q36987361 | Translation and Clinical Development of Antithrombotic Aptamers |
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