Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation

scientific article published on 19 November 2015

Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2015-04-638387
P932PMC publication ID4742550
P698PubMed publication ID26585954

P50authorBrian EstevezQ96026832
Bo ShenQ54557826
P2093author name stringXiaoping Du
Aleksandra Stojanovic-Terpo
Jaehyung Cho
Kyungho Kim
M Keegan Delaney
Zaverio M Ruggeri
Changgeng Ruan
P2860cites workGlycoproteins V and Ib-IX form a noncovalent complex in the platelet membraneQ24297475
The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequenceQ24298201
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin bindingQ24314966
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factorQ24317407
Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activationQ24337851
Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structuresQ24339565
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombinQ24563384
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivoQ24669536
Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite IQ27667770
PAR3 is a cofactor for PAR4 activation by thrombinQ28141872
Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complexQ28245163
Cloning and characterization of the gene encoding the human platelet glycoprotein V. A member of the leucine-rich glycoprotein family cleaved during thrombin-induced platelet activationQ28264692
Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresisQ67556563
A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in plateletsQ69972771
Thrombin binds to a high-affinity approximately 900 000-dalton site on human plateletsQ70084953
Contributions of glycoprotein Ib and the seven transmembrane domain receptor to increases in platelet cytoplasmic [Ca2+] induced by alpha-thrombinQ70862491
Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von WQ71145591
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsQ72033892
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alphaQ72272743
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationQ28275839
Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alphaQ28278900
Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membraneQ28304653
Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury modelQ28509120
Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndromeQ28509360
Increased thrombin responsiveness in platelets from mice lacking glycoprotein VQ28586401
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosisQ30478277
A directional switch of integrin signalling and a new anti-thrombotic strategyQ30557151
The cytoplasmic domain of the platelet glycoprotein Ibalpha is phosphorylated at serine 609.Q30811815
Role for platelet glycoprotein Ib-IX and effects of its inhibition in endotoxemia-induced thrombosis, thrombocytopenia, and mortalityQ33410457
Role of thrombin signalling in platelets in haemostasis and thrombosisQ34090283
A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.Q34106615
Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism.Q34209358
Thrombin generation and fibrin clot structureQ34598931
Signaling and regulation of the platelet glycoprotein Ib-IX-V complexQ34616663
High-affinity alpha-thrombin binding to platelet glycoprotein Ib alpha: identification of two binding domainsQ35569261
Platelet glycoprotein Ib alpha supports experimental lung metastasisQ35829198
Hirudin as a molecular probe for thrombin in vitro and during systemic coagulation in the pig.Q36133849
The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoAQ36156836
Protease-activated receptors in hemostasis, thrombosis and vascular biologyQ36230881
Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelQ36316299
Intertwining of thrombosis and inflammation in atherosclerosisQ36667645
LIM kinase-1 selectively promotes glycoprotein Ib-IX-mediated TXA2 synthesis, platelet activation, and thrombosisQ36889753
Reduced thrombin binding and aggregation in Bernard-Soulier plateletsQ37052459
Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombinQ37565691
Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact plateletsQ38306581
Platelet glycoprotein Ib-IX as a regulator of systemic inflammation.Q38829029
Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complexQ40995210
A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implicationsQ42092628
The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activationQ42131574
PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change.Q43757370
Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signalingQ43977694
Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin.Q44503897
Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregatesQ45882791
Interaction of purified actin-binding protein with the platelet membrane glycoprotein Ib-IX complexQ46859763
Abnormal spine morphology and enhanced LTP in LIMK-1 knockout miceQ48545185
Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein IbQ53061821
Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation.Q53537273
P433issue5
P407language of work or nameEnglishQ1860
P1104number of pages11
P304page(s)626-636
P577publication date2015-11-19
P1433published inBloodQ885070
P1476titleSignaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
P478volume127

Reverse relations

cites work (P2860)
Q5233062214-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.
Q46247855A novel flow cytometry assay using dihydroethidium as redox-sensitive probe reveals NADPH oxidase-dependent generation of superoxide anion in human platelets exposed to amyloid peptide β.
Q33442233Cab4b, the first human platelet antigen carried by glycoprotein IX discovered in a context of severe neonatal thrombocytopenia.
Q52448095Challenges on the diagnostic approach of inherited platelet function disorders: Is a paradigm change necessary?
Q64929172Cyclic nucleotide-dependent inhibitory signaling interweaves with activating pathways to determine platelet responses.
Q35961805Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis
Q36133779Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation
Q33784320HPW-RX40 prevents human platelet activation by attenuating cell surface protein disulfide isomerases
Q39147112New Concepts and Mechanisms of Platelet Activation Signaling
Q51263915Paradoxical bleeding and thrombotic episodes of dysprothrombinaemia due to a homozygous Arg382His mutation.
Q37097085Protease-activated receptors in hemostasis
Q88938168Shear-induced integrin signaling in platelet phosphatidylserine exposure, microvesicle release, and coagulation
Q92239487The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System
Q93038200The secret afterlife of platelets
Q90098435cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

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