The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA

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The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1091/MBC.E15-05-0274
P932PMC publication ID4603935
P698PubMed publication ID26310447

P50authorBo ShenQ54557826
P2093author name stringXiaoping Du
Zheng Xu
Feng Qian
Barry Kreutz
Yanyan Bai
Deane Mosher
Andrei Karginov
Brian Estevez
Urao Norifumi
P2860cites workSrc kinase activation by direct interaction with the integrin β cytoplasmic domainQ24298960
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF.Q24541352
Cell migration: integrating signals from front to backQ27860670
Cell migration: a physically integrated molecular processQ27860682
Integrins: bidirectional, allosteric signaling machinesQ27860700
The G protein G alpha(13) is required for growth factor-induced cell migrationQ28243364
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13Q28274717
Getting to the site of inflammation: the leukocyte adhesion cascade updatedQ29547271
In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitroQ29617927
Coordination of Rho GTPase activities during cell protrusionQ29618432
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
SH2- and SH3-mediated interactions between focal adhesion kinase and Src.Q30176302
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domainQ30194432
Integrins in cell migrationQ30417364
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.Q30417648
A directional switch of integrin signalling and a new anti-thrombotic strategyQ30557151
G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signalingQ33743722
RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarityQ33946704
Integrins and Src: dynamic duo of adhesion signalingQ34432517
The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.Q34575941
Signaling during platelet adhesion and activationQ34895427
RhoA and RhoC have distinct roles in migration and invasion by acting through different targetsQ35196063
A molecular switch that controls cell spreading and retractionQ36119672
Activation of p115-RhoGEF requires direct association of Gα13 and the Dbl homology domainQ36127073
Integrin regulationQ36229087
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.Q36232656
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinityQ36237442
Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domainQ36289167
Induction of cell scattering by expression of beta1 integrins in beta1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin functionQ36313391
Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelQ36316299
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signalingQ36323239
beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1.Q37134457
Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healingQ37675931
Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction.Q38043667
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.Q38311815
Galpha12/13 is essential for directed cell migration and localized Rho-Dia1 functionQ40357788
Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.Q40663995
Synergism among lysophosphatidic acid, beta1A integrins, and epidermal growth factor or platelet-derived growth factor in mediation of cell migrationQ40953022
Beta 1 integrin-dependent and -independent polymerization of fibronectinQ41254786
Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migrationQ41821246
Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFsQ42033646
ADP-stimulated activation of Akt during integrin outside-in signaling promotes platelet spreading by inhibiting glycogen synthase kinase-3β.Q42326649
G12/G13 family G proteins regulate marginal zone B cell maturation, migration, and polarizationQ42500065
A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin.Q42823002
Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.Q42825992
Expression of integrin β1 by fibroblasts is required for tissue repair in vivoQ42861079
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migrationQ46815318
Restoration of beta1A integrins is required for lysophosphatidic acid-induced migration of beta1-null mouse fibroblastic cellsQ47792573
Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.Q53365686
Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanismQ73938784
P4510describes a project that usesImageJQ1659584
P433issue20
P921main subjectcell migrationQ189092
P1104number of pages13
P304page(s)3658-3670
P577publication date2015-08-26
P1433published inMolecular Biology of the CellQ2338259
P1476titleThe interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoA
P478volume26

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cites work (P2860)
Q36169826Attractor landscape analysis of colorectal tumorigenesis and its reversion
Q49663364By modulating α2β1 integrin signalling, gastrin increases adhesion oF AGS-GR gastric cancer cells
Q59789123Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity
Q36778873GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells
Q36928462Galectin-3 Enhances Migration of Minature Pig Bone Marrow Mesenchymal Stem Cells Through Inhibition of RhoA-GTP Activity
Q38644725Integrin αIIbβ3 outside-in signaling.
Q95580547Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cells
Q38985544Molecular mechanisms regulating aquaporin-2 in kidney collecting duct
Q50437489RIC8A is essential for the organisation of actin cytoskeleton and cell-matrix interaction
Q36547814Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
Q36748646Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-κB Cascade on Human Pulmonary Alveolar Epithelial Cells
Q57294138The Ric-8A/Gα13/FAK signaling cascade controls focal adhesion formation during neural crest cell migration
Q26742035Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues