| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1034316186 |
| P356 | DOI | 10.1038/35007085 |
| P3181 | OpenCitations bibliographic resource ID | 771890 |
| P698 | PubMed publication ID | 10766244 |
| P5875 | ResearchGate publication ID | 12550790 |
| P2093 | author name string | S R Coughlin | |
| Y W Zheng | |||
| E J Weiss | |||
| M Nakanishi-Matsui | |||
| D J Sulciner | |||
| M J Ludeman | |||
| P2860 | cites work | Heterodimerization is required for the formation of a functional GABA(B) receptor | Q22008591 |
| Protease-activated receptor 3 is a second thrombin receptor in humans | Q24310957 | ||
| Cloning and characterization of human protease-activated receptor 4 | Q24322941 | ||
| Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation | Q24337851 | ||
| Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway | Q24531184 | ||
| Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin | Q24563384 | ||
| G-protein-coupled receptor heterodimerization modulates receptor function | Q24603239 | ||
| Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes | Q27731248 | ||
| A dual thrombin receptor system for platelet activation | Q28280578 | ||
| How the protease thrombin talks to cells | Q33740137 | ||
| GABA(B)-receptor subtypes assemble into functional heteromeric complexes. | Q34485514 | ||
| Role of heteromer formation in GABAB receptor function | Q34485603 | ||
| Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin | Q40402483 | ||
| Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction | Q40962119 | ||
| Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes. | Q41357890 | ||
| Domains specifying thrombin–receptor interaction | Q46311150 | ||
| Determinants of thrombin receptor cleavage. Receptor domains involved, specificity, and role of the P3 aspartate | Q71869446 | ||
| P433 | issue | 6778 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 609-13 | |
| P577 | publication date | 2000-04-06 | |
| P1433 | published in | Nature | Q180445 |
| P1476 | title | PAR3 is a cofactor for PAR4 activation by thrombin | |
| P478 | volume | 404 |
| Q35784515 | A balance between TFPI and thrombin-mediated platelet activation is required for murine embryonic development |
| Q33267507 | A comprehensive proteomics and genomics analysis reveals novel transmembrane proteins in human platelets and mouse megakaryocytes including G6b-B, a novel immunoreceptor tyrosine-based inhibitory motif protein |
| Q33416544 | A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs? |
| Q40003955 | A novel secreted protease from Pseudomonas aeruginosa activates NF-kappaB through protease-activated receptors |
| Q28748458 | A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo |
| Q37428002 | A role for thrombin in the initiation of the immune response to therapeutic factor VIII. |
| Q35749110 | Aberrant Expression and Activation of the Thrombin Receptor Protease-Activated Receptor-1 Induces Cell Proliferation and Motility in Human Colon Cancer Cells |
| Q40251372 | Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo |
| Q28587775 | Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3 |
| Q36478416 | Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin |
| Q43968783 | Activation of Rap1B by G(i) family members in platelets |
| Q44485850 | Activation of mast cells induced by agonists of proteinase-activated receptors under normal conditions and during acute inflammation in rats |
| Q35363647 | Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts |
| Q73209504 | Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP |
| Q34543233 | Allosteric modulation of protease-activated receptor signaling |
| Q24291430 | Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion |
| Q78306580 | Attacked from within, blood thins |
| Q38214613 | Biased signaling of protease-activated receptors |
| Q37635262 | Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease. |
| Q38306581 | Binding of thrombin to glycoprotein Ib accelerates the hydrolysis of Par-1 on intact platelets |
| Q36843696 | CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets |
| Q34584466 | Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets |
| Q35941710 | Cathepsin K induces platelet dysfunction and affects cell signaling in breast cancer - molecularly distinct behavior of cathepsin K in breast cancer |
| Q36464966 | Characterization of a new peptide agonist of the protease-activated receptor-1. |
| Q47872081 | Chronic LiCl pretreatment suppresses thrombin-stimulated intracellular calcium mobilization through TRPC3 in astroglioma cells |
| Q54196585 | Chymotrypsin Enhances Soluble Fms-Like Tyrosine Kinase 1 Production Through Protease-Activated Receptor 2 in Placenta-Derived Immortalized Human Trophoblast Cells. |
| Q37236116 | Cofactoring and dimerization of proteinase-activated receptors |
| Q34312730 | Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin |
| Q46444362 | Coordinate activation of human platelet protease-activated receptor-1 and -4 in response to subnanomolar alpha-thrombin |
| Q27660263 | Crystal Structure of Thrombin Bound to the Uncleaved Extracellular Fragment of PAR1 |
| Q27646532 | Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4 |
| Q41773964 | Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. |
| Q34571203 | Dancing with multiple partners |
| Q36483421 | Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent |
| Q40499214 | Different Expression of Hypoxic and Angiogenic Factors in Human Endometriotic Lesions |
| Q28578185 | Differential expression, time course and distribution of four PARs in rats with endotoxin-induced acute lung injury |
| Q33580620 | Differential signaling by protease-activated receptors: implications for therapeutic targeting. |
| Q35592680 | Dimerization of G-protein-coupled receptors: roles in signal transduction |
| Q55468635 | Dysfunctional platelet membrane receptors: from humans to mice. |
| Q35043001 | Enhanced contractile response to thrombin in the pregnant rat myometrium |
| Q27027602 | Enteric bacterial proteases in inflammatory bowel disease- pathophysiology and clinical implications |
| Q39212164 | EprS, an autotransporter protein of Pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors |
| Q33614606 | Evaluation on potential contributions of protease activated receptors related mediators in allergic inflammation |
| Q46643296 | Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis |
| Q43741286 | FXa-induced responses in vascular wall cells are PAR-mediated and inhibited by ZK-807834. |
| Q34566260 | Factor VIIa/tissue factor-induced signaling: a link between clotting and disease |
| Q39626396 | Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. |
| Q37107067 | Featured Article: Differential regulation of endothelial nitric oxide synthase phosphorylation by protease-activated receptors in adult human endothelial cells |
| Q43825696 | Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling |
| Q52620808 | Functional cyclophilin D moderates platelet adhesion, but enhances the lytic resistance of fibrin. |
| Q47849270 | Functional links between Disabled-2 Ser723 phosphorylation and thrombin signaling in human platelets |
| Q36997717 | Gastrointestinal roles for proteinase-activated receptors in health and disease |
| Q37066273 | Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. |
| Q35346534 | Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. |
| Q64094981 | Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal |
| Q28362035 | Glycosylation and the activation of proteinase-activated receptor 2 (PAR(2)) by human mast cell tryptase |
| Q28743018 | Granzyme K activates protease-activated receptor-1 |
| Q38109969 | Harnessing the platelet signaling network to produce an optimal hemostatic response. |
| Q34442026 | Heterodimerization of G-protein-coupled receptors in the CNS. |
| Q35544489 | Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function |
| Q43727874 | Human cytomegalovirus increases HUVEC sensitivity to thrombin and modulates expression of thrombin receptors. |
| Q36176326 | Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets. |
| Q40405585 | Identification and expression patterns of members of the protease-activated receptor (PAR) gene family during zebrafish development. |
| Q46209213 | Impaired hemostasis and protection against thrombosis in protease-activated receptor 4-deficient mice is due to lack of thrombin signaling in platelets |
| Q28345742 | In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse |
| Q24685396 | Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2 |
| Q33942052 | Inhibition of SRC family kinases protects hippocampal neurons and improves cognitive function after traumatic brain injury |
| Q73128626 | Inhibition of arterial thrombosis by a peptide ligand of the thrombin receptor |
| Q40491633 | Inter- and intra-specific gene-density-correlated radial chromosome territory arrangements are conserved in Old World monkeys |
| Q36908851 | Interaction of thrombin with PAR1 and PAR4 at the thrombin cleavage site |
| Q35910761 | Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. |
| Q40007756 | Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression |
| Q58699560 | Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms |
| Q36708674 | Ligand binding to anion-binding exosites regulates conformational properties of thrombin |
| Q33657566 | Local protease signaling contributes to neural tube closure in the mouse embryo |
| Q35879995 | Mapping human protease-activated receptor 4 (PAR4) homodimer interface to transmembrane helix 4 |
| Q45202849 | Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4. |
| Q46701587 | Mast cells are critical for the limitation of thrombin-induced skin inflammation |
| Q28192472 | Mechanisms of action of proteinase-activated receptor agonists on human platelets |
| Q34626040 | Mechanisms of disease: protease functions in intestinal mucosal pathobiology |
| Q48449125 | Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes. |
| Q33756072 | Modulation of expression of innate immunity markers CXCL5/ENA-78 and CCL20/MIP3alpha by protease-activated receptors (PARs) in human gingival epithelial cells |
| Q74527941 | Molecular mapping of thrombin-receptor interactions |
| Q51810799 | Murine thrombin lacks Na+ activation but retains high catalytic activity. |
| Q33229884 | Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo |
| Q37217154 | Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity |
| Q39147112 | New Concepts and Mechanisms of Platelet Activation Signaling |
| Q34448237 | New antiinflammatory and platelet-preserving effects of aprotinin |
| Q34580126 | Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity |
| Q37065714 | Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3. |
| Q27348034 | Novel mouse hemostasis model for real-time determination of bleeding time and hemostatic plug composition. |
| Q28202666 | PAR-3 is a low-affinity substrate, high affinity effector of thrombin |
| Q40591380 | PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation |
| Q44459219 | Persistent protease-activated receptor 4 signaling mediates thrombin-induced microglial activation |
| Q44770013 | Plasmin-mediated activation of platelets occurs by cleavage of protease-activated receptor 4. |
| Q37807924 | Platelet receptor signaling in thrombus formation |
| Q26824744 | Platelet signaling |
| Q37982455 | Platelet signaling-a primer. |
| Q35168904 | Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets |
| Q37641556 | Platelet thrombin receptor antagonism and atherothrombosis |
| Q36230859 | Platelets in atherothrombosis: lessons from mouse models |
| Q49801741 | Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; The experiment by neonatal rat atrial fibroblasts |
| Q35119422 | Protease activated receptors 1 and 4 govern the responses of human platelets to thrombin |
| Q41959040 | Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones |
| Q34225983 | Protease activated receptors: theme and variations |
| Q46251817 | Protease signaling in tumor progression |
| Q50002204 | Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy. |
| Q26744512 | Protease-Activated Receptors and other G-Protein-Coupled Receptors: the Melanoma Connection |
| Q51784457 | Protease-activated receptor (Par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function. |
| Q37289265 | Protease-activated receptor 1 (PAR1) and PAR4 heterodimers are required for PAR1-enhanced cleavage of PAR4 by α-thrombin |
| Q37942473 | Protease-activated receptor 2 signaling in inflammation |
| Q38239636 | Protease-activated receptor 4: a critical participator in inflammatory response |
| Q38722647 | Protease-activated receptor 4: from structure to function and back again |
| Q35720592 | Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization |
| Q24530570 | Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage |
| Q28580202 | Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation |
| Q35107634 | Protease-activated receptors |
| Q64105617 | Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases |
| Q37447476 | Protease-activated receptors and prostaglandins in inflammatory lung disease. |
| Q38680840 | Protease-activated receptors and their biological role - focused on skin inflammation |
| Q42849011 | Protease-activated receptors as therapeutic targets in visceral pain. |
| Q37097085 | Protease-activated receptors in hemostasis |
| Q35204291 | Protease-activated receptors in the Achilles tendon-a potential explanation for the excessive pain signalling in tendinopathy |
| Q35176854 | Protease-activated receptors in the cardiovascular system |
| Q34450747 | Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis |
| Q36268344 | Protease-activated receptors: potential therapeutic targets in irritable bowel syndrome? |
| Q36211460 | Protease-activated receptors: regulation of neuronal function |
| Q37853216 | Proteases as therapeutics |
| Q35114471 | Proteases display biased agonism at protease-activated receptors: location matters! |
| Q26999113 | Protein C anticoagulant and cytoprotective pathways |
| Q37938191 | Protein kinase C-theta in platelet activation |
| Q61337152 | Proteinase-activated receptor expression and function in the brain |
| Q43263886 | Proteinase-activated receptor-1 agonists attenuate nociception in response to noxious stimuli |
| Q33895918 | Proteinase-activated receptor-2 up-regulation by Fcgamma-receptor activation in human neutrophils |
| Q37348262 | Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact |
| Q35610289 | Proteinase-activated receptors in the nervous system |
| Q35209223 | Proteinase-activated receptors: novel signals for peripheral nerves. |
| Q35579639 | Proteinase-mediated signaling: Proteinase-activated receptors (PARs) and much more |
| Q37024500 | Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. |
| Q38966192 | Proteinases, Their Extracellular Targets, and Inflammatory Signaling. |
| Q28647166 | Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection |
| Q45713881 | Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts |
| Q33390301 | Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis |
| Q48377404 | Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2. |
| Q41880869 | Redundancy and interaction of thrombin- and collagen-mediated platelet activation in tail bleeding and carotid thrombosis in mice |
| Q33444919 | Regulation of plasmin-induced protease-activated receptor 4 activation in platelets |
| Q35064562 | Regulation of protease-activated receptor signaling by post-translational modifications |
| Q28266829 | Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors |
| Q45038622 | Role of CL-100, a dual specificity phosphatase, in thrombin-induced endothelial cell activation |
| Q73320927 | Role of Gαq and phospholipase C‐β2 in human platelets activation by thrombin receptors PAR1 and PAR4: studies in human platelets deficient in Gαq and phospholipase C‐β2 |
| Q35562739 | Role of Protease-activated Receptors in the Vascular System |
| Q34874973 | Role of protease-activated receptors in airway function: a target for therapeutic intervention? |
| Q34090283 | Role of thrombin signalling in platelets in haemostasis and thrombosis |
| Q34276408 | Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis |
| Q42044945 | Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo |
| Q90724393 | Roles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases |
| Q33615082 | Roles of PAR1 and PAR2 in viral myocarditis. |
| Q37588688 | SCH 530348: a novel oral thrombin receptor antagonist |
| Q33870369 | Signal transduction by protease-activated receptors |
| Q34895427 | Signaling during platelet adhesion and activation |
| Q36547814 | Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation |
| Q24682815 | Signalling pathways induced by protease-activated receptors and integrins in T cells |
| Q28188159 | Specificity of coagulation factor signaling |
| Q44619566 | Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats |
| Q37893582 | Structural basis of thrombin-protease-activated receptor interactions |
| Q27649783 | Structural identification of the pathway of long-range communication in an allosteric enzyme |
| Q41732034 | Structure-function analysis of protease-activated receptor 4 tethered ligand peptides. Determinants of specificity and utility in assays of receptor function |
| Q37454193 | Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platelet adhesion to collagen |
| Q73004111 | Substrate-assisted catalysis of the PAR1 thrombin receptor. Enhancement of macromolecular association and cleavage |
| Q39338913 | Targeting PAR1: Now What? |
| Q39024744 | Targeting coagulation factor receptors - protease-activated receptors in idiopathic pulmonary fibrosis |
| Q37972789 | Targeting proteinase-activated receptors: therapeutic potential and challenges. |
| Q44899120 | Tethered ligand-derived peptides of proteinase-activated receptor 3 (PAR3) activate PAR1 and PAR2 in Jurkat T cells |
| Q41883410 | The APCs of neuroprotection |
| Q34492360 | The antithrombotic and antiinflammatory mechanisms of action of aprotinin |
| Q40704613 | The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process |
| Q92518346 | The neuro-glial coagulonome: the thrombin receptor and coagulation pathways as major players in neurological diseases |
| Q46602316 | The non-proteolytically active thrombin peptide TP508 stimulates angiogenic sprouting |
| Q38843498 | The paradox of painless periodontal disease. |
| Q35056060 | Therapeutic potential of protease-activated receptor-1 antagonists |
| Q90053693 | Therapeutic strategies for thrombosis: new targets and approaches |
| Q36800534 | Thrombin |
| Q36058083 | Thrombin activity associated with neuronal damage during acute focal ischemia |
| Q98577691 | Thrombin alters the synthesis and processing of CYR61/CCN1 in human corneal stromal fibroblasts and myofibroblasts through multiple distinct mechanisms |
| Q34269077 | Thrombin and Phenotypic Modulation of the Endothelium |
| Q34291931 | Thrombin domains: structure, function and interaction with platelet receptors |
| Q53470416 | Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells. |
| Q33566993 | Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway |
| Q58796994 | Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease-activated receptor 1- and protease-activated receptor 4-dependent mechanism |
| Q29619601 | Thrombin signalling and protease-activated receptors |
| Q44659688 | Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism |
| Q38829694 | Thrombin-Induced Podocyte Injury Is Protease-Activated Receptor Dependent |
| Q38787747 | Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling. |
| Q28188207 | Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP |
| Q88207375 | Thrombin-induced platelet activation via PAR4: pivotal role for exosite II |
| Q24673493 | Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist |
| Q42127781 | Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα. |
| Q37018287 | Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells |
| Q37624589 | Thrombin-targeted liposomes establish a sustained localized anticlotting barrier against acute thrombosis |
| Q36779515 | Transactivation of the PAR1-PAR2 heterodimer by thrombin elicits β-arrestin-mediated endosomal signaling |
| Q36164146 | Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation |
| Q54409466 | Trypsin causes platelet activation independently of known protease-activated receptors. |
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