Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib

scientific article published on October 12, 2010

Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1160/TH10-09-0578
P953full work available at URLhttps://europepmc.org/articles/pmc3810535?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941453/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20941453/pdf/?tool=EBI
https://europepmc.org/articles/PMC3810535
http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH10-09-0578.pdf
https://doi.org/10.1160/th10-09-0578
https://europepmc.org/articles/PMC3810535?pdf=render
P932PMC publication ID3810535
P698PubMed publication ID20941453

P2093author name stringHua Jing
Alessandro Zarpellon
James R. Roberts
Zaverio M. Ruggeri
Richard A. Mc Clintock
G. Loredana Mendolicchio
P2860cites workGlycoproteins V and Ib-IX form a noncovalent complex in the platelet membraneQ24297475
The glycocalicin portion of platelet glycoprotein Ib expresses both high and moderate affinity receptor sites for thrombin. A soluble radioreceptor assay for the interaction of thrombin with plateletsQ24299800
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domainQ24304907
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein IbalphaQ24307780
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin bindingQ24314966
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutationsQ24319306
Platelets mediate cytotoxic T lymphocyte-induced liver damageQ24604707
HBV pathogenesis in animal models: recent advances on the role of plateletsQ24672103
Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting plateletQ24681433
Crystal structure of the platelet glycoprotein Ib(alpha) N-terminal domain reveals an unmasking mechanism for receptor activationQ27639267
Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregationQ27641665
The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsQ27642041
Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complexQ28247125
A dual thrombin receptor system for platelet activationQ28280578
Zebrafish: a genetic model for hemostasis and thrombosis.Q31139050
In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation.Q33323650
Platelet physiology and abnormalities of platelet function (second of two parts).Q33334020
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.Q33378211
Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.Q33480624
Platelets in Inflammation and ThrombosisQ34263823
Are thrombocytes and platelets true phagocytes?Q34733277
Platelets in atherothrombosisQ34986345
The GPIbalpha-thrombin interaction: far from crystal clear.Q35628260
Change in protein phenotype without a nucleus: translational control in plateletsQ35881295
Mechanisms of thrombopoiesisQ36230854
Platelets in inflammation and atherogenesis.Q36328825
Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/CD18)Q36368770
The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectinQ36375314
The structure of thrombin: a janus-headed proteinaseQ36467880
The interaction of bacterial pathogens with plateletsQ36482515
Antimicrobial peptides versus invasive infectionsQ36566203
The role of junctional adhesion molecules in vascular inflammationQ36831671
Adhesion mechanisms in platelet functionQ36856340
Factor VIII procoagulant protein.Q39848910
Platelet physiology and abnormalities of platelet function (first of two parts).Q39944486
The role of haemostatic mechanismsQ40321584
Crystal structure of the thrombin-hirudin complex: a novel mode of serine protease inhibitionQ41240502
Thrombin Receptors of Human Platelets: Thrombin Binding and Antithrombin Properties of Glycoprotein IQ41724872
Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.Q41934357
Platelet glycoprotein Ib: a zinc-dependent binding protein for the heavy chain of high-molecular-weight kininogenQ41942712
Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptorsQ42054506
Thrombin interaction with platelet glycoprotein Ib: effect of glycocalicin on thrombin specificityQ43494167
Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.Q43782195
von Willebrand factor. A reduced and alkylated 52/48-kDa fragment beginning at amino acid residue 449 contains the domain interacting with platelet glycoprotein Ib.Q44319614
The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II.Q44763814
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated plateletQ45064186
Comparison of sea turtle thrombocyte aggregation to human platelet aggregation in whole bloodQ46720146
Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injuryQ46783981
Expression of human platelet glycoprotein Ib alpha in transgenic miceQ46900695
Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2.Q47698131
Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist.Q50877980
Identification of a Binding Site for Glycoprotein Ibα in the Apple 3 Domain of Factor XIQ57372279
Characteristics of the interaction between thrombin exosite 1 and the sequence 269-287 [correction of 269-297] of platelet glycoprotein IbalphaQ58425867
Dynamic Visualization of Thrombopoiesis Within Bone MarrowQ58450371
Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.Q60265904
Platelet glycocalicin: a single receptor for platelet aggregation induced by thrombin or ristocetinQ67750250
Effect of the hirudin carboxy-terminal peptide 54-65 on the interaction of thrombin with plateletsQ67768931
Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombinQ67775135
Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factorQ70237272
von Willebrand diseaseQ70321843
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alphaQ72272743
The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activityQ72992335
Thrombin interaction with platelet GpIB: role of the heparin binding domainQ73305324
Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregationQ73763204
The platelet high affinity binding site for thrombin mimics hirudin, modulates thrombin-induced platelet activation, and is distinct from the glycoprotein Ib-IX-V complexQ77747933
Involvement of platelet glycoprotein Ib in platelet microparticle mediated neutrophil activationQ80082294
P433issue5
P407language of work or nameEnglishQ1860
P921main subjecthemostasisQ487937
P304page(s)894-902
P577publication date2010-10-12
P1433published inThrombosis and HaemostasisQ15724413
P1476titleUnravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib
P478volume104

Reverse relations

cites work (P2860)
Q27667770Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I
Q30650321Genetic deletion of platelet glycoprotein Ib alpha but not its extracellular domain protects from atherosclerosis
Q35185593Historical perspective and future directions in platelet research
Q36432676Incidence of Platelet Dysfunction by Thromboelastography-Platelet Mapping in Children Supported with ECMO: A Pilot Retrospective Study.
Q38128303On the versatility of von Willebrand factor
Q35779411Platelet-neutrophil interactions under thromboinflammatory conditions
Q90403621Platelets Are at the Nexus of Vascular Diseases
Q36547814Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation
Q28236023Targeting the GPIbα binding site of thrombin to simultaneously induce dual anticoagulant and antiplatelet effects
Q45245513Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

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