The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III

scientific article published on 01 February 2000

The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.275.6.3887
P698PubMed publication ID10660541

P50authorSergio RutellaQ42054583
Erica De CandiaQ61160323
P2093author name stringJ I Weitz
R De Cristofaro
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3887-3895
P577publication date2000-02-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III
P478volume275

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cites work (P2860)
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Q34106615A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V.
Q77296407Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II
Q27667770Binding of  -thrombin to surface-anchored platelet glycoprotein Ib  sulfotyrosines through a two-site mechanism involving exosite I
Q33480624Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.
Q24598030Crystal structure of the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor
Q36053189Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function
Q44518940Fibrinogen gamma' chain binds thrombin exosite II.
Q42054506Fibrinogen-elongated gamma chain inhibits thrombin-induced platelet response, hindering the interaction with different receptors
Q27680808GpIbα Interacts Exclusively with Exosite II of Thrombin
Q38109969Harnessing the platelet signaling network to produce an optimal hemostatic response.
Q73763204Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation
Q41934357Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.
Q60265904Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin.
Q34264585Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2.
Q36800534Thrombin
Q45063820Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively
Q34291931Thrombin domains: structure, function and interaction with platelet receptors
Q41901939Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb

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