| scholarly article | Q13442814 |
| P2093 | author name string | A. Tulinsky | |
| E. Di Cera | |||
| A. Vindigni | |||
| E. R. Guinto | |||
| Q. D. Dang | |||
| Y. M. Ayala | |||
| M. Wuyi | |||
| P2860 | cites work | MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures | Q26778412 |
| The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships | Q27642041 | ||
| Refined structure of the hirudin-thrombin complex | Q27653704 | ||
| Crystallographic structures of thrombin complexed with thrombin receptor peptides: existence of expected and novel binding modes | Q27731248 | ||
| Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate | Q27731337 | ||
| Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites | Q27731968 | ||
| Human D-Phe-Pro-Arg-CH2-alpha-thrombin crystallization and diffraction data | Q31113237 | ||
| An allosteric switch controls the procoagulant and anticoagulant activities of thrombin | Q34172057 | ||
| The interaction of thrombin with fibrinogen. A structural basis for its specificity | Q34416186 | ||
| Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species | Q36921502 | ||
| A player of many parts: the spotlight falls on thrombin's structure. | Q40893212 | ||
| Analysis of progress curves by simulations generated by numerical integration | Q42835646 | ||
| The effect of metal ions on the amidolytic activity of human factor Xa (Activated Stuart-Prower Factor) | Q44640516 | ||
| Thrombin is a Na(+)-activated enzyme | Q45261449 | ||
| Kinetic characterization of heparin-catalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin. | Q52405045 | ||
| Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system. | Q52706984 | ||
| Solution structure of a platelet receptor peptide bound to bovine alpha-thrombin | Q67506987 | ||
| Evidence that human alpha-thrombin is a monovalent cation-activated enzyme | Q71257633 | ||
| Enzymes activated by monovalent cations | Q71504941 | ||
| Stimulation of the amidase and esterase activity of activated bovine plasma protein C by monovalent cations | Q71848720 | ||
| Molecular recognition by thrombin. Role of the slow-->fast transition, site-specific ion binding energetics and thermodynamic mapping of structural components | Q72726469 | ||
| A simple activity assay for thrombin and hirudin | Q72871873 | ||
| P433 | issue | 38 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 22089-22092 | |
| P577 | publication date | 1995-09-01 | |
| 1995-09-22 | |||
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | The Na+ binding site of thrombin | |
| The Na+ Binding Site of Thrombin | |||
| P478 | volume | 270 |
| Q44727035 | A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin |
| Q42042690 | A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P(2). |
| Q45998339 | Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa. |
| Q48741452 | Amino acids involved in sodium interaction of murine type II Na(+)-P(i) cotransporters expressed in Xenopus oocytes |
| Q51708222 | Anticoagulant thrombins. |
| Q37685016 | Automated identification of elemental ions in macromolecular crystal structures |
| Q36279496 | Cation selective promotion of tubulin polymerization by alkali metal chlorides |
| Q36280688 | Cluster analysis of consensus water sites in thrombin and trypsin shows conservation between serine proteases and contributions to ligand specificity |
| Q37103942 | Control of ion selectivity in LeuT: two Na+ binding sites with two different mechanisms |
| Q73289680 | Critical role of W60d in thrombin allostery |
| Q27665368 | Crystal structure of prethrombin-1 |
| Q27639560 | Crystal structure of the anticoagulant slow form of thrombin |
| Q40726200 | Crystal structure of wild-type human thrombin in the Na+-free state. |
| Q34041148 | Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site |
| Q88316482 | Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin |
| Q28550480 | Dynamics Govern Specificity of a Protein-Protein Interface: Substrate Recognition by Thrombin |
| Q42156369 | Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin |
| Q27650197 | Engineering Protein Allostery: 1.05 Å Resolution Structure and Enzymatic Properties of a Na+-activated Trypsin |
| Q43600479 | Enhancement of chymotrypsin-inhibitor/substrate interactions by 3 M NaCl. |
| Q27734002 | Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design |
| Q34630229 | Evidence of the E*−E Equilibrium from Rapid Kinetics of Na+ Binding to Activated Protein C and Factor Xa* |
| Q84509369 | Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes |
| Q36737737 | Factor Va alters the conformation of the Na+-binding loop of factor Xa in the prothrombinase complex |
| Q27681443 | Functional and Structural Characterization of Vibrio cholerae Extracellular Serine Protease B, VesB |
| Q46409985 | Functional requirements for inhibition of thrombin by antithrombin III in the presence and absence of heparin |
| Q71483760 | Functionality map analysis of the active site cleft of human thrombin |
| Q41868886 | Heparin enhances the catalytic activity of des-ETW-thrombin |
| Q33382168 | How Na+ activates thrombin--a review of the functional and structural data |
| Q33763127 | Identification of residues linked to the slow-->fast transition of thrombin |
| Q37037369 | Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa |
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| Q27640131 | Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations |
| Q35055092 | Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation |
| Q37279262 | Ions and inhibitors in the binding site of HIV protease: comparison of Monte Carlo simulations and the linearized Poisson-Boltzmann theory |
| Q41837193 | Kinetic and chemical mechanisms for the effects of univalent cations on the spectral properties of aromatic amine dehydrogenase |
| Q36049897 | Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold |
| Q27714094 | Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin |
| Q54606763 | Mechanistic insights into thrombin's switch between "slow" and "fast" forms. |
| Q38909804 | Molecular Mechanisms of Enzyme Activation by Monovalent Cations. |
| Q37318220 | Mutagenesis studies toward understanding allostery in thrombin |
| Q27657884 | Mutant N143P Reveals How Na+ Activates Thrombin |
| Q73007036 | Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin |
| Q27652506 | Na+ binding to meizothrombin desF1 |
| Q62763945 | Na+-binding modes involved in thrombin's allosteric response as revealed by molecular dynamics simulations, correlation networks and Markov modeling |
| Q34457491 | Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). |
| Q77771911 | New general approach for determining the solution structure of a ligand bound weakly to a receptor: structure of a fibrinogen Aalpha-like peptide bound to thrombin (S195A) obtained using NOE distance constraints and an ECEPP/3 flexible docking progr |
| Q41010993 | PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins. |
| Q60265904 | Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. |
| Q47245406 | Predicting Displaceable Water Sites Using Mixed-Solvent Molecular Dynamics |
| Q28348323 | Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates |
| Q50422267 | Probing light chain mutation effects on thrombin via molecular dynamics simulations and machine learning. |
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| Q27640311 | Reconstructing the binding site of factor Xa in trypsin reveals ligand-induced structural plasticity |
| Q34750145 | Redesigning allosteric activation in an enzyme |
| Q33713006 | Redesigning the monovalent cation specificity of an enzyme |
| Q37289290 | Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases |
| Q27667649 | Rigidification of the autolysis loop enhances Na+ binding to thrombin |
| Q33177672 | Role of P225 and the C136-C201 disulfide bond in tissue plasminogen activator |
| Q91620222 | Role of the I16-D194 ionic interaction in the trypsin fold |
| Q36639229 | Salt-induced stabilization of apoflavodoxin at neutral pH is mediated through cation-specific effects |
| Q48007250 | Site-specific analysis of mutational effects in proteins. |
| Q87257470 | Sodium and Potassium Ions in Proteins and Enzyme Catalysis |
| Q92890846 | Sodium-induced population shift drives activation of thrombin |
| Q35963392 | Steric selectivity in Na channels arising from protein polarization and mobile side chains. |
| Q38015147 | Structural biology of factor VIIa/tissue factor initiated coagulation |
| Q27649783 | Structural identification of the pathway of long-range communication in an allosteric enzyme |
| Q35214029 | Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies |
| Q34341165 | Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. |
| Q33509504 | Structure-based predictive models for allosteric hot spots |
| Q34750443 | Switching cation-binding loops paves the way for redesigning allosteric activation |
| Q31108281 | Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases |
| Q35766982 | Synthetic receptors as models for alkali metal cation-pi binding sites in proteins |
| Q37829641 | THE ROLE OF INTRACELLULAR SODIUM (Na) IN THE REGULATION OF CALCIUM (Ca)-MEDIATED SIGNALING AND TOXICITY. |
| Q36280463 | The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding |
| Q27640906 | The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form |
| Q27736084 | The molecular environment of the Na+ binding site of thrombin |
| Q74233352 | The preparation and catalytic properties of recombinant human prostate-specific antigen (rPSA) |
| Q53626760 | The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII. |
| Q34016899 | Theory of allosteric effects in serine proteases. |
| Q43587867 | Thermodynamics of Na+ binding to coagulation serine proteases |
| Q44257223 | Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites |
| Q36800534 | Thrombin |
| Q45063820 | Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively |
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| Q73107571 | Thrombin inhibitor design: X-ray and solution studies provide a novel P1 determinant |
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| Q27617423 | Unexpected crucial role of residue 225 in serine proteases |
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