scholarly article | Q13442814 |
P356 | DOI | 10.1021/BI00162A008 |
P698 | PubMed publication ID | 1445907 |
P2093 | author name string | E. Di Cera | |
C. M. Wells | |||
P433 | issue | 47 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 11721-11730 | |
P577 | publication date | 1992-12-01 | |
P1433 | published in | Biochemistry | Q764876 |
P1476 | title | Thrombin is a Na(+)-activated enzyme | |
P478 | volume | 31 |
Q41818930 | 3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions |
Q44727035 | A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin |
Q72871873 | A simple activity assay for thrombin and hirudin |
Q41763804 | A simple method for the determination of individual rate constants for substrate hydrolysis by serine proteases |
Q37441223 | Activation mechanisms of coagulation factor IX. |
Q27655102 | Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations |
Q56838379 | Aluminum modulation of proteolytic activities |
Q34172057 | An allosteric switch controls the procoagulant and anticoagulant activities of thrombin |
Q51708222 | Anticoagulant thrombins. |
Q57078614 | Binding of Fibrinogen Aα1–50-β-Galactosidase Fusion Protein to Thrombin Stabilizes the Slow Form |
Q26853115 | Biomolecular electrostatics and solvation: a computational perspective |
Q44629157 | Catalytic behaviors of enzymes attached to nanoparticles: the effect of particle mobility |
Q33509255 | Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite Sarcoptes scabiei |
Q73289680 | Critical role of W60d in thrombin allostery |
Q45293182 | Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery |
Q27639121 | Crystal structure of the Homer 1 family conserved region reveals the interaction between the EVH1 domain and own proline-rich motif |
Q27639560 | Crystal structure of the anticoagulant slow form of thrombin |
Q40726200 | Crystal structure of wild-type human thrombin in the Na+-free state. |
Q36819410 | Design of Factor XIII V34X activation peptides to control ability to interact with thrombin mutants |
Q36293491 | Determinants of specificity in coagulation proteases |
Q39658447 | Differential Ca2+ signaling by thrombin and protease-activated receptor-1-activating peptide in human brain microvascular endothelial cells |
Q52020204 | Dissecting substrate recognition by thrombin using the inactive mutant S195A. |
Q44590854 | Distortion of the Catalytic Domain of Tissue-type Plasminogen Activator by Plasminogen Activator Inhibitor-1 Coincides with the Formation of Stable Serpin-Proteinase Complexes |
Q33657850 | Does chemical cross-linking with NHS esters reflect the chemical equilibrium of protein-protein noncovalent interactions in solution? |
Q77631620 | Dynamics of clot growth induced by thrombin diffusing into nonstirred citrate human plasma |
Q42156369 | Effect of Na+ binding on the conformation, stability and molecular recognition properties of thrombin |
Q42138714 | Effect of temperature on the association step in thrombin-fibrinogen interaction |
Q42414567 | Energy variational analysis of ions in water and channels: Field theory for primitive models of complex ionic fluids |
Q28392085 | Entropy-enthalpy transduction caused by conformational shifts can obscure the forces driving protein-ligand binding |
Q77811643 | Evidence for multiple enzyme site involvement in the modulation of thrombin activity by products of prothrombin proteolysis |
Q34630229 | Evidence of the E*−E Equilibrium from Rapid Kinetics of Na+ Binding to Activated Protein C and Factor Xa* |
Q45881688 | Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain |
Q36884329 | Exosites in the substrate specificity of blood coagulation reactions |
Q36538526 | Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation |
Q44497180 | Further evidence for the reliance of catalysis by rabbit muscle pyruvate kinase upon isomerization of the ternary complex between enzyme and products |
Q33382168 | How Na+ activates thrombin--a review of the functional and structural data |
Q91494891 | Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain |
Q33763127 | Identification of residues linked to the slow-->fast transition of thrombin |
Q27646778 | Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery |
Q35055092 | Involvement of the Na+/H+ exchanger in membrane phosphatidylserine exposure during human platelet activation |
Q36049897 | Kinetic dissection of the pre-existing conformational equilibrium in the trypsin fold |
Q34121251 | Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states |
Q36844385 | Locating the rate-determining step(s) for three-step hydrolase-catalyzed reactions with DYNAFIT |
Q37848282 | Looking at the proteases from a simple perspective. |
Q27714094 | Loop Electrostatics Asymmetry Modulates the Preexisting Conformational Equilibrium in Thrombin |
Q51607642 | Loop-driven conformational transition between the alternative and collapsed form of prethrombin-2: targeted molecular dynamics study. |
Q54606763 | Mechanistic insights into thrombin's switch between "slow" and "fast" forms. |
Q73740174 | Modulation of human alpha-thrombin activity with phosphonate ester inhibitors |
Q47581912 | Molecular dissection of Na+ binding to thrombin. |
Q51810799 | Murine thrombin lacks Na+ activation but retains high catalytic activity. |
Q27657884 | Mutant N143P Reveals How Na+ Activates Thrombin |
Q34069668 | NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation. |
Q37563464 | NMR reveals a dynamic allosteric pathway in thrombin. |
Q27652506 | Na+ binding to meizothrombin desF1 |
Q62763945 | Na+-binding modes involved in thrombin's allosteric response as revealed by molecular dynamics simulations, correlation networks and Markov modeling |
Q34457491 | Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). |
Q77771911 | New general approach for determining the solution structure of a ligand bound weakly to a receptor: structure of a fibrinogen Aalpha-like peptide bound to thrombin (S195A) obtained using NOE distance constraints and an ECEPP/3 flexible docking progr |
Q40144947 | Non-canonical proteolytic activation of human prothrombin by subtilisin from Bacillus subtilis may shift the procoagulant-anticoagulant equilibrium toward thrombosis |
Q34041257 | On the structural basis for ionic selectivity among Na+, K+, and Ca2+ in the voltage-gated sodium channel |
Q46936908 | Ostrich antithrombin III: kinetics and mechanism of inhibition of ostrich thrombin |
Q41010993 | PDBSiteScan: a program for searching for active, binding and posttranslational modification sites in the 3D structures of proteins. |
Q60265904 | Platelet glycoprotein Ib alpha binds to thrombin anion-binding exosite II inducing allosteric changes in the activity of thrombin. |
Q35004486 | Predicting Ca(2+)-binding sites in proteins |
Q47245406 | Predicting Displaceable Water Sites Using Mixed-Solvent Molecular Dynamics |
Q28348323 | Preparation of anhydrothrombin and characterization of its interaction with natural thrombin substrates |
Q40714392 | Prothrombinase assembly and S1 site occupation restore the catalytic activity of FXa impaired by mutation at the sodium-binding site |
Q33567518 | Proton bridging in the interactions of thrombin with small inhibitors |
Q73077242 | Rational engineering of activity and specificity in a serine protease |
Q54077153 | Reactivity of Lys(NH2)-containing peptides toward endopeptidases. |
Q34750145 | Redesigning allosteric activation in an enzyme |
Q33713006 | Redesigning the monovalent cation specificity of an enzyme |
Q37289290 | Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases |
Q44695944 | Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin |
Q27667649 | Rigidification of the autolysis loop enhances Na+ binding to thrombin |
Q36610450 | Role of Na+ and K+ in enzyme function |
Q41987240 | Role of the A chain in thrombin function |
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Q73555471 | Selective loss of fibrinogen clotting in a loop-less thrombin |
Q48007250 | Site-specific analysis of mutational effects in proteins. |
Q36883970 | Site-specific dissection of substrate recognition by thrombin |
Q37278697 | Slow thrombin is zymogen-like |
Q87257470 | Sodium and Potassium Ions in Proteins and Enzyme Catalysis |
Q92890846 | Sodium-induced population shift drives activation of thrombin |
Q35963392 | Steric selectivity in Na channels arising from protein polarization and mobile side chains. |
Q37779571 | Structural and mechanistic insight into how antibodies inhibit serine proteases. |
Q27644424 | Structural basis of Na+ activation mimicry in murine thrombin |
Q27649783 | Structural identification of the pathway of long-range communication in an allosteric enzyme |
Q35214029 | Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies |
Q33509504 | Structure-based predictive models for allosteric hot spots |
Q34750443 | Switching cation-binding loops paves the way for redesigning allosteric activation |
Q72054938 | The Na+ Binding Site of Thrombin |
Q44512860 | The bovine lung 20S proteasome binding to reversible inhibitors: modulation by sodium ion. |
Q36280463 | The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding |
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Q27640906 | The molecular basis of thrombin allostery revealed by a 1.8 A structure of the "slow" form |
Q27736084 | The molecular environment of the Na+ binding site of thrombin |
Q46860761 | The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding |
Q74233352 | The preparation and catalytic properties of recombinant human prostate-specific antigen (rPSA) |
Q53626760 | The structural integrity of anion binding exosite I of thrombin is required and sufficient for timely cleavage and activation of factor V and factor VIII. |
Q42619428 | The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin |
Q34016899 | Theory of allosteric effects in serine proteases. |
Q27639032 | Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). Sodium ion in the APC crystal structure is coordinated to four carbonyl groups from two separate loops |
Q44426958 | Thermodynamic non-ideality as an alternative source of the effect of sucrose on the thrombin-catalyzed hydrolysis of peptide p-nitroanilide substrates. |
Q43587867 | Thermodynamics of Na+ binding to coagulation serine proteases |
Q36800534 | Thrombin |
Q34291931 | Thrombin domains: structure, function and interaction with platelet receptors |
Q33328373 | Thrombin hydrolysis of human osteopontin is dependent on thrombin anion-binding exosites |
Q73107571 | Thrombin inhibitor design: X-ray and solution studies provide a novel P1 determinant |
Q40932840 | Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains |
Q93015446 | Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis |
Q45865558 | Type II protein C deficiency: identification and molecular modelling of two natural mutants with low anticoagulant and normal amidolytic activity. |
Q47129907 | Uncovering Large-Scale Conformational Change in Molecular Dynamics without Prior Knowledge |
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Q27682457 | X-ray Structures of Human Furin in Complex with Competitive Inhibitors |
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