Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila

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Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila is …
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scholarly articleQ13442814

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P356DOI10.1242/DEV.077644
P932PMC publication ID3403109
P698PubMed publication ID22791894
P5875ResearchGate publication ID229082896

P50authorJulie A. BrillQ47503289
Jason BurgessQ57337454
Cheng-I Jonathan MaQ64604911
Helmut KrämerQ37376723
P2093author name stringGordon Polevoy
Barbara Barylko
Joseph P Albanesi
Janet Rollins
Lauren M Del Bel
P2860cites workThe retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi networkQ24305021
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complexQ24306457
GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote buddingQ24336708
EpsinR: an ENTH domain-containing protein that interacts with AP-1.Q24550798
EpsinR: an AP1/clathrin interacting protein involved in vesicle traffickingQ24675918
A Drosophila full-length cDNA resourceQ24803485
PtdIns4 P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi traffickingQ27658740
Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent proteinQ27861056
Saccharomyces cerevisiae contains a Type II phosphoinositide 4-kinaseQ27929859
PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.Q27930562
The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the GolgiQ27931832
Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamicsQ27933485
The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activityQ27938509
Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiaeQ27939346
Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viabilityQ27939746
ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complexQ28137865
A novel family of phosphatidylinositol 4-kinases conserved from yeast to humansQ28204394
Phosphatidylinositol 4-kinases: old enzymes with emerging functionsQ28247845
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complexQ28267260
Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7.Q28299673
Distinct Golgi populations of phosphatidylinositol 4-phosphate regulated by phosphatidylinositol 4-kinasesQ28301255
The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cellsQ28572918
Vectors for P-mediated transformation in DrosophilaQ39303518
Drosophila Sgs genes: stage and tissue specificity of hormone responsivenessQ40964870
Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.Q41064785
Intracellular transport of secretory proteins in the pancreatic exocrine cell. II. Transport to condensing vacuoles and zymogen granulesQ41096456
Larval saliva in Drosophila melanogaster: Production, composition, and relationship to chromosome puffsQ41281306
Polarized secretion of an ectopic protein in Drosophila salivary glands in vivoQ41347187
Regulation and recruitment of phosphatidylinositol 4-kinase on immature secretory granules is independent of ADP-ribosylation factor 1.Q41875140
Phosphatidylinositol 4-kinase, but not phosphatidylinositol 3-kinase, is present in GLUT4-containing vesicles isolated from rat skeletal muscleQ42462018
The endocytic pathway and formation of the Wingless morphogen gradientQ42487988
Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles.Q42800351
Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression.Q42915467
The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptorsQ45234393
Differentiation in the salivary glands of Drosophila melanogaster: characterization of the glue proteins and their developmental appearanceQ45285586
cis-acting DNA sequence requirements for P-element transpositionQ46461617
Wingless secretion promotes and requires retromer-dependent cycling of WntlessQ47070108
CrebA regulates secretory activity in the Drosophila salivary gland and epidermisQ47070754
Syntaxin 5 is required for cytokinesis and spermatid differentiation in Drosophila.Q47070982
AP-1 controls the trafficking of Notch and Sanpodo toward E-cadherin junctions in sensory organ precursorsQ47071480
Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells.Q47071677
A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesisQ47071777
Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granulesQ47071892
SNAP-24, a Drosophila SNAP-25 homologue on granule membranes, is a putative mediator of secretion and granule-granule fusion in salivary glandsQ47072829
Developmental regulation of granule size and numbers in larval salivary glands of drosophila by steroid hormone ecdysoneQ47243115
Rickettsia-like mitochondrial motility in Drosophila spermiogenesisQ47388501
Three new Drosophila markers of intracellular membranesQ47580713
The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome.Q52244245
Spindles and centrosomes during male meiosis in Drosophila melanogaster.Q52448933
Phosphatidylinositol 4-kinase is a component of glucose transporter (GLUT 4)-containing vesiclesQ68244971
Purification and kinetic properties of a membrane-bound phosphatidylinositol kinase of the bovine adrenal medullaQ68449879
A comparative ultrastructural study of 'glue' production and secretion of the salivary glands in different species of theDrosophila melanogaster groupQ89558398
Synthesis and secretion of mucoprotein glue in the salivary gland ofDrosophila melanogasterQ89558707
Analysis of the catalytic domain of phosphatidylinositol 4-kinase type IIQ28572996
Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesiclesQ28573277
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome trafficQ28583370
Subcellular locations of phosphatidylinositol 4-kinase isoformsQ28678847
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cellsQ29547331
Using FlyAtlas to identify better Drosophila melanogaster models of human diseaseQ29615721
Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axonsQ30488804
Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogasterQ30492987
A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathwayQ30493237
AP-1 and clathrin are essential for secretory granule biogenesis in DrosophilaQ30501068
The Drosophila gene collection: identification of putative full-length cDNAs for 70% of D. melanogaster genesQ30842858
Glue secretion in the Drosophila salivary gland: a model for steroid-regulated exocytosisQ31951583
A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of DrosophilaQ33345240
Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesisQ33589995
Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesiclesQ33911122
Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartmentsQ34121202
Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.Q34151690
Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the GolgiQ34221739
Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase.Q34254743
Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptorQ34489231
Timing and targeting of P-element local transposition in the male germline cells of Drosophila melanogasterQ34614560
Coordination of Golgi functions by phosphatidylinositol 4-kinasesQ34644921
Palmitoylation controls the catalytic activity and subcellular distribution of phosphatidylinositol 4-kinase II{alpha}Q34943159
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cellsQ34982315
Intracellular transport of secretory proteins in the pancreatic exocrine cell. I. Role of the peripheral elements of the Golgi complexQ36189154
Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularizationQ36316531
A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motilityQ36320343
The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.Q37182226
Crystal structure of the clathrin adaptor protein 1 coreQ37557309
Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis.Q38848293
P433issue16
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
Vacuolar protein sorting 29 Dmel_CG4764Q29811106
Rab7 Dmel_CG5915Q29816601
Synaptosomal-associated protein 24kDa Dmel_CG9474Q29820564
P1104number of pages11
P304page(s)3040-3050
P577publication date2012-07-12
P1433published inDevelopmentQ3025404
P1476titleType II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila
P478volume139

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cites work (P2860)
Q58695574A molecular switch orchestrates enzyme specificity and secretory granule morphology
Q30576113A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
Q89655660An early endosome-derived retrograde trafficking pathway promotes secretory granule maturation
Q27343089Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism.
Q27340369Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo
Q30586751BMP-regulated exosomes from Drosophila male reproductive glands reprogram female behavior
Q90013255Cdc42 controls secretory granules morphology in rodent salivary glands in vivo
Q90425509Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1
Q28301748Cinderella story: PI4P goes from precursor to key signaling molecule
Q34112710Endosomal sorting of VAMP3 is regulated by PI4K2A.
Q39598956Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P.
Q54119901Genetic dissection of the phosphoinositide cycle in Drosophila photoreceptors.
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Q89068607Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development
Q36810817IL13 activates autophagy to regulate secretion in airway epithelial cells
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Q92333871Phosphatidylinositol 4,5-bisphosphate controls Rab7 and PLEKHM1 membrane cycling during autophagosome-lysosome fusion
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Q37094181Role of adaptor proteins in secretory granule biogenesis and maturation
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Q27701469The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design
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Q90359253Tied up: Does altering phosphoinositide-mediated membrane trafficking influence neurodegenerative disease phenotypes?
Q36932357Type II PI4-kinases control Weibel-Palade body biogenesis and von Willebrand factor structure in human endothelial cells
Q50605863Vacuole dynamics in the salivary glands of Drosophila melanogaster during prepupal development.
Q50323081Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.

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